Intramuscularly, intravenously (struyno and drip). The dosage regimen and duration of the course of treatment are set individually, taking into account the indications, severity of the course,localization of infection and sensitivity of the pathogen. Average daily dose for adults - 1-4 g; the frequency of administration is 3-4 times a day. The maximum daily dose is 6 g. The average duration of treatment is 7-10 days.
Dosing instructions for adults:
| Type of infection | Single dose | Multiplicity of the introduction |
| Infections of the lung course caused by sensitive Gram-positive microorganisms | 0.25-0.5 g | every 8 hours |
| Pneumococcal pneumonia | 0.5 g | every 12 hours |
| Acute uncomplicated urinary tract infections | 1.0 g | every 12 hours |
| Infections of medium gravity and severe | 0.5-1 g | After 6 to 8 hours |
| Severe, life-threatening infections: endocarditis, septicemia | 1 - 1.5 g | After 6 hours |
Prevention of postoperative infection
The dose and frequency of administration depends on the type and duration of the operation. Intravenous or intramuscular injection of 1 g for 30 minutes - 1 hour before surgery. Dose is sufficient for minor surgical interventions of short duration.
For prolonged surgical operations (more than 2 hours), in addition, from 0.5 g to 1 g intravenously or intramuscularly during the operation. During the day after the operation, 0.5 g-1 g every 6-8 hours.
Use in patients with impaired renal function
Patients with impaired renal function require a change in the dosage regimen in accordance with the values of creatinine clearance (CC):
- with a SC of 55 ml / min or more, or with a plasma creatinine concentration of 1.5 mg% or less, a full dose can be administered;
- with SC 54-35 ml / min or at a plasma creatinine concentration of 3-1.6 mg% - the total dose can be given, but the intervals between injections can be increased to 8 hours;
- with SC 34-11 ml / min or creatinine concentration in plasma of 4.5-3.1 mg% 1/2 doses at intervals of 12 h;
- with CC 10 ml / min or less, or with a plasma creatinine concentration of 4.6 mg% or more - 1/2 average dose every 18-24 hours.
All recommended doses are administered after the initial dose corresponding to the severity of the infection.
Use in children with normal renal function
Average daily dose for children - 1 month and older - 25-50 mg / kg; In severe infection, the dose can be increased to 100 mg / kg / day. Multiplicity of administration - 3-4 times a day.
Use in children with impaired renal function
Correction of the dosing regimen is performed depending on the values of creatinine clearance (CK):
- with SC 70-40 ml / min - 60% of the average daily dose and administered after 12 hours;
- with KK 40-20 ml / min - 25% of the average daily dose with an interval of 12 hours;
- with KK 5-20 ml / min - 10% of the average daily dose every 24 hours.
All recommended doses are administered after the initial dose corresponding to the severity of the infection.
Preparation of solutions:
For intramuscular injection 500 mg of the drug is dissolved in 2 ml of water for injection, 1000 mg in 4 ml of water for injection.
For intravenous drip the drug is dissolved in 50-100 ml of a 0.9% solution of sodium chloride or 5-10% solution of dextrose, Ringer's solution, 5% sodium bicarbonate solution. Infusion is carried out for 20 - 30 minutes (rate of administration of 60 - 80 drops per minute).
For intravenous fluid administration a single dose of the drug is diluted in 10 ml of water for injection and injected slowly for 3-5 minutes.
During the dilution, the vials are vigorously shaken until completely dissolved.