Intramuscularly, intravenously (struino or drip).
The average daily intake for adults is 1 g; the frequency of administration is 2 times a day. The maximum daily dose is 6 g, the frequency of administration can be increased up to 3-4 times a day.
The average duration of treatment with Cesolin is 7-10 days.For the prevention of postoperative infection - 1 g for 30 min before the operation, 0.5-1 g - for the operation time and for 0.5-1 g - every 6-8 h within 24 hours after the operation.
Patients with impaired renal function require a change in the dosing regimen, in accordance with the values of creatinine clearance (CK). With SC 55 ml / min or more, or with a plasma creatinine content of 1.5 mg% or less, a full dose can be administered. With SC 54-35 ml / min, or with a creatinine content of 3-1.6 mg% in the plasma, a full dose can be given, but the intervals between injections can be increased to 8 hours. With QA 34-11 ml / min or creatinine in plasma 4, 5-3.1 mg% - 1/2 dose at 12 hour intervals. Patients with CC 10 ml / min or less, or with a plasma creatinine content of 4.6 mg% or more - 1/2 of the average dose every 18-24 h. All recommended doses are administered after the initial shock dose.
The average daily dose for children is 20-50 mg / kg; In severe infection, the dose can be increased to 100 mg / kg / day. Multiplicity of administration - 3-4 times a day. In children with impaired renal function, correction of the dosing regimen is performed depending on the values of the CC. With CC 70-40 ml / min - 60% of the average daily dose and injected after 12 hours. At KK 40-20 ml / min - 25% of the average daily dose with an interval of 12 hours. Children with KK 5-20 ml / min - 10% of the average daily dose every 24 hours.All recommended doses are given after the initial shock dose.
Preparation of solutions.
For intramuscular injection, the drug is dissolved in 2-3 ml of water for injection, isotonic sodium chloride solution or 0.25-0.5% solution of novocaine and injected deep into the muscle.
For intravenous drip, the drug is dissolved in 100-250 ml of isotonic sodium chloride solution or 5% glucose solution; infusion is carried out for 20-30 minutes (rate of administration of 60-80 drops per minute).
For intravenous fluid administration, a single dose of the drug is diluted in 10 ml of isotonic sodium chloride solution and injected slowly for 3-5 minutes.
During the dilution, the vials are vigorously shaken until the powder is completely dissolved.