Allergic reactions: hyperthermia, skin rash, urticaria, skin itching, bronchospasm, eosinophilia, Quincke's edema, arthralgia, anaphylactic shock, erythema multiforme, malignant exudative erythema (Stevens-Johnson syndrome).
From the nervous system: convulsions.
From the urinary system: in patients with kidney disease in the treatment of large doses (6 g) - renal dysfunction (in these cases, the dose is reduced and the treatment is controlled by the dynamics of urea nitrogen and creatinine in the blood).
From the digestive system: nausea, vomiting, diarrhea, abdominal pain, pseudomembranous enterocolitis, rarely - cholestatic jaundice, hepatitis.
On the part of the organs of hematopoiesis: leukopenia, neutropenia, thrombocytopenia, thrombocytosis, hemolytic anemia.
With long-term treatment - Dysbacteriosis, superinfection caused by antibiotic-resistant strains, candidamycosis (including candidiasis stomatitis).
Laboratory indicators: a positive Coombs reaction, an increase in the activity of "liver" transaminases, hypercreatininaemia, an increase in prothrombin time.
Local Reactions: with the / m introduction - soreness (at the injection site), with / in the introduction - phlebitis.