Dosing regimen and duration of treatment are set individually,taking into account the indications, the severity of the course, the localization of the infection and the sensitivity of the pathogen.
The average daily intake for adults is 1000-4000 mg; the frequency of administration is 3-4 times a day. The maximum daily dose is 6000 mg. The average duration of treatment is 7-10 days.
For the prevention of postoperative infection - intravenously, 1000 mg 0.5-1 h before the operation, 500-1000 mg - during the operation and 500-1000 mg - every 8 hours during the first day after the operation.
Patients with impaired renal function a change in the dosage regimen is required in accordance with the values of creatinine clearance: with creatinine clearance of 55 ml / min or more, or with a plasma creatinine concentration of 1.5 mg% or less, a full dose can be administered; with a creatinine clearance of 54-35 ml / min or a plasma creatinine concentration of 3-1.6 mg%, a full dose can be administered, but the intervals between injections should be increased to 8 hours; with a creatinine clearance of 34-11 ml / min or a creatinine concentration in the plasma of 4.5-3.1 mg% - 1/2 dose at intervals of 12 hours; with a creatinine clearance of 10 ml / min or less, or with a plasma creatinine concentration of 4.6 mg% or more - 1/2 the usual dose every 18-24 hours.
All recommended doses are administered, after the initial dose corresponding to the severity of the flow.
Children 1 month and older - 25-50 mg / kg / day; In severe infection, the dose can be increased to 100 mg / kg / day. Multiplicity of administration - 3-4 times a day.
In children with impaired renal function correction of the dosing regimen is carried out depending on the values of creatinine clearance: at creatinine clearance of 70-40 ml / min - 60% of the average daily dose is administered every 12 hours; at a creatinine clearance of 40-20 ml / min - 25% of the average daily dose with an interval of 12 hours; with a creatinine clearance of 5-20 ml / min - 10% of the average daily dose every 24 hours. All recommended doses are administered after the initial dose corresponding to the severity of the flow.
For infections of moderate severity caused by sensitive Gram-positive microorganisms, single dose for adults - 250-500 mg every 8 hours.
With pneumococcal pneumonia - 500 mg every 12 hours, with acute uncomplicated urinary tract diseases -1000 mg every 12 hours.
Preparation of solutions for injection and infusion: 500 mg of the drug are dissolved in 2 ml of water for injection, 1000 mg in 4 ml of water for injection.
For intravenous bolus administration, the resulting solution is diluted with 5 ml of water for injection, then injected slowly, for 3-5 minutes.
For intravenous drip, 50-100 ml of a 5-10% solution of dextrose, 0.9% sodium chloride solution, Ringer's solution,5% solution of sodium bicarbonate. During the dilution, vials should be vigorously shaken until completely dissolved.