Allergic reactions: hyperthermia, skin rash, urticaria, skin itching, bronchospasm, eosinophilia, Quincke's edema, arthralgia, anaphylactic shock, erythema multiforme, malignant exudative erythema (Stevens-Johnson syndrome).
From the nervous system: convulsions.
From the side of the urinary system: in patients with kidney disease in the treatment of large doses (6 g) - renal dysfunction (in these cases, the dose is reduced and treatment is controlled by the dynamics of urea nitrogen and creatinine in the blood).
On the part of the digestive system: nausea, vomiting, diarrhea, abdominal pain, pseudomembranous enterocolitis, rarely - cholestatic jaundice, hepatitis.
From the hematopoiesis: leukopenia, neutropenia, thrombocytopenia, thrombocytosis, hemolytic anemia.
With long-term treatment - dysbacteriosis, superinfection caused by antibiotic-resistant strains, candidiasis (including candidiasis stomatitis).
Laboratory indicators: positive Coombs reaction, increased activity of "liver" transaminases, hypercreatininaemia, increased prothrombin time.
Local reactions: with the / m introduction - soreness (at the injection site), with / in the introduction - phlebitis.