Vitamin B1 - instructions for use, dose, side effects, contraindications

In the body it is converted into an active thiamine pyrophosphate and as a coenzyme is included in the pyruvate decarboxylase and alpha-ketoglutarate decarboxylase complexes,which participate in the oxidative decarboxylation of pyruvic and alpha-ketoglutaric acids; transketolase - an enzyme of the pentose phosphate shunt.

Pharmacokinetics:

In the blood, the concentration is relatively low, while in plasma there is a predominantly free thiamine, in erythrocytes and leukocytes its phosphoric, ethers. Phosphorylation occurs in the liver. The most active phosphoric ester is thiamine diphosphate, which possesses coenzyme activity. It accumulates mainly in the liver, heart, brain, kidneys, spleen. 1/2 of the total amount is contained in striated muscles and myocardium and about 40% in internal organs. It is excreted through the intestines and kidneys.

Indications:

Hypovitaminosis and vitamin B deficiency₁, including in patients who are on probe nutrition, hemodialysis, with malabsorption syndrome.

Contraindications:Increased individual sensitivity, pregnancy, lactation, children's age.

Carefully:Encephalopathy Wernicke, premenopausal and climacteric period in women.

Dosing and Administration:

Intramuscularly (deep into the muscle).

Begin the administration of the drug is recommended with small doses (not more than 0.5 ml of solution)

and only with good tolerability, higher doses are administered.

Adults appoint 20-50 mg of thiamine (0.5-1 ml) once a day.

The course of treatment is 10-30 injections.

Side effects:

Allergic reactions (urticaria, skin itching, angioedema, rarely - anaphylactic shock), increased sweating, tachycardia. Soreness (due to low pH of solutions) with intramuscular injection is rare.

Overdose:

In case of an overdose of vitamin B₁ increases the activity of acetylcholine, which plays an important role in the pathogenesis of allergies. Prolonged administration of excessive doses of vitamin B1 can lead to discoordination of the enzyme systems of the liver and its fatty degeneration, impaired renal function.

Treatment: conduct symptomatic therapy.

Interaction:

Thiamine solution should not be mixed with solutions containing sulfites, t. in them it completely disintegrates. It is not recommended simultaneous parenteral administration of thiamine with pyridoxine or cyanocobalamin: pyridoxine makes it difficult to convert thiamine into a biologically active form, cyanocobalamin enhances the allergenic effect of thiamine. Do not mix in one syringe thiamine with benzylpenicillin or streptomycin (destruction of antibiotics), thiamine and nicotinic acid (destruction of thiamine). Thiamine reduces the pharmacological activity of suxamethonium iodide, phentolamine, propanolol, sympatholytics (reserpine), hypnotics (reduces hypnotics and hypotensive effects). Thiamine is unstable in alkaline and neutral solutions; administration with carbonates, citrates, barbiturates with Cu²⁺ not recommended.

Special instructions:

When determining the concentration of theophylline in the blood serum by the spectrophotometric method, urobilinogen can be distorted by Ehrlich's reagent (when taking high doses). Do not use instead of substitute - balanced diet, only in combination with diet therapy.

Parenteral administration is recommended only if oral administration (nausea, vomiting, malabsorption syndrome, preoperative and / or postoperative conditions) is not possible. With Wernicke's encephalopathy, the administration of dextrose should precede the use of thiamine.

Effect on the ability to drive transp. cf. and fur:

Form release / dosage:

Solution for intramuscular injection 50 mg / ml.

Packaging:1 ml of the drug in neutral glass ampoules, with a notch marked with a dot (paint). 10 ampoules are placed in a contour mesh package made of a polyvinyl chloride film. 1 circuit cell pack together with instructions for use "is placed in a pack of cardboard.

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:

3 years.

Do not use after expiry date.

Terms of leave from pharmacies:On prescription

Registration number:LP-001230

Date of registration:17.11.2011

Expiration Date:17.11.2016

The owner of the registration certificate: Mapichem AG Mapichem AG Switzerland

Manufacturer: & nbsp

CSPC OUYI PHARMACEUTICAL, Co.Ltd. China

Representation: & nbspMapichem AGMapichem AG

Information update date: & nbsp21.02.2017

Illustrated instructions

Instructions

Vitamin B1 (Vitamin B1)