Thiamine chloride-ECHO (Thiamine chloride-ECHO)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceThiamineThiamine
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  • Thiamine chloride-ECHO
    capsules inwards 
    ECHO NPK, Joint Stock Company     Russia
    • Dosage form: & nbspcapsules
    Composition:
    Active ingredient: Thiamine hydrochloride (vitamin Bj) - 100 mg. Excipients: sucrose - 229 mg, potato starch - 60 mg, calcium stearate - 8 mg, povidone - 3 mg.
    The composition of the capsule: dye quinoline yellow - 0.9197%, dye "sunset sun" yellow - 0.0044%, titanium dioxide - 1.3333%, gelatin - up to 100%.

    Description:
    Hard gelatin capsules No. 0 of yellow color. The contents of the capsule are a mixture of granules and white or white powder with a creamy shade of color with a weak characteristic odor.

    Pharmacotherapeutic group:vitamin preparation
    ATX: & nbsp

    A.11.D.A.01   Thiamine

    Pharmacodynamics:
    Vitamin B) In the body it is converted to the active thiamine pyrophosphate and as a coenzyme is included in the pyruvate decarboxylase, alpha-ketoglutarate decarboxylase complex, which participate in the oxidative decarboxylation of pyruvic and alpha-ketoglutaric acids; transketolase - an enzyme of the pentose phosphate shunt.

    Pharmacokinetics:
    Absorption is high, all over the small intestine. Before absorption, it is released from the bound state by digestive enzymes. After 15 minutes it is found in the blood, after 30 minutes - in other tissues. In the blood, the concentration is relatively low, while the plasma circulates predominantly free thiamine, in erythrocytes and leukocytes - its phosphoric esters. Phosphorylation occurs in the liver. The most active phosphoric ester is thiamine diphosphate, which has coenzyme activity. It is found mainly in striated muscles, liver, heart, brain, kidneys, spleen, half of them in striated muscle and myocardium, and about 40% in internal organs. It is excreted through the intestines and kidneys.

    Indications:
    Treatment of hypovitaminosis and vitamin B1

    Contraindications:
    Hypersensitivity to the components of the drug; deficiency of sugar / isomaltase, intolerance to fructose, glucose-galactose malabsorption; children's age till 18 years.

    Carefully:
    Encephalopathy Wernicke.

    Pregnancy and lactation:
    It is used in accordance with indications for use.

    Dosing and Administration:Inside, after a meal, 100 mg (1 capsule) for 2-3 weeks.
    Side effects:Allergic reactions (urticaria, skin itching, angioedema, anaphylactic shock), increased sweating, tachycardia.
    Overdose:not described
    Interaction:Ethanol slows the rate of absorption of thiamine after oral administration.
    Special instructions:
    When taking the recommended doses during pregnancy, breastfeeding, as well as in elderly people, there were no adverse reactions other than those mentioned above.
    When determining theophylline in the blood serum by the spectrophotometric method, urobilinogen with the help of Ehrlich reagent can distort the results (when taking high doses).
    More often the anaphylactic reaction develops after IV in the administration of large doses.
    With encephalopathy Wernicke, the administration of thiamine should be preceded by the administration of dextrose.


    Effect on the ability to drive transp. cf. and fur:The effect on the ability to drive vehicles and mechanisms has not been studied.
    Form release / dosage:Capsules.
    Packaging:

    30 capsules in cans of polymer with shock absorber and cover pulled with the control of the first opening or cans of polymer with screwed cover, covered packing film PVC Shrinkable.

    Free space in the banks is filled with cotton absorbent medical cotton. Each bank along with the instruction for use is placed in a pack of cardboard.

    Storage conditions:
    In a dry, protected from light place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

    Shelf life:
    3 years. Do not use at the end of the expiration date printed on the package.

    Terms of leave from pharmacies:Without recipe
    Registration number:P N002506 / 01
    Date of registration:15.12.2008
    The owner of the registration certificate:ECHO NPK, Joint Stock Company ECHO NPK, Joint Stock Company Russia
    Manufacturer: & nbsp
    Information update date: & nbsp27.08.2015
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