Thiamine - instructions for use, dose, side effects, contraindications

Vitamin B1 (thiamine) refers to water-soluble vitamins. In the human body, as a result of phosphorylation processes, it turns into cocarboxylase, which is a coenzyme of many enzymatic reactions.It plays an important role in the carbohydrate, protein and fat metabolism, in the processes of conduction of nervous excitation in the synapses.

Pharmacokinetics:

Absorption is high, throughout the small intestine. In the blood, the concentration is relatively low, while the plasma circulates predominantly free thiamine, in erythrocytes and leukocytes - its phosphoric esters. Phosphorylation occurs in the liver. The most active phosphoric ester is thiamine diphosphate, which has coenzymic activity. It accumulates mainly in the liver, heart, brain, kidneys, spleen. 1/2 of the total is contained in striated muscle and myocardium and about 40% in internal organs. It is excreted through the intestines and kidneys.

Indications:

Hypovitaminosis and vitamin B1. complex therapy:

neuritis, sciatica; neuralgia; peripheral paresis and paralysis;

- ulcer disease of the stomach and duodenum; decrease in secretory and motor function of the stomach, anorexia, intestinal atony; atonic constipation;

- Myocardial dystrophy; violation of the coronary circulation;

-diabetes;

dermatoses (eczema, neurodermatitis, psoriasis, lichen planus) with neurotrophic changes and metabolic disorders.

Contraindications:

Increased individual sensitivity to the components of the drug.

Carefully:

encephalopathy Wernicke, women in premenopausal and climacteric periods

Dosing and Administration:

Thiamine solution is administered intramuscularly (deep into the muscle).

Begin the administration of the drug is recommended with small doses (no more than 0.5 ml of a 5% solution) and only with good tolerance go to higher doses.

Adults appoint 25-50 mg thiamine chloride (1 ml of 2.5% or 5% solution) once a day, daily. To children - on 0,0125 g (0,5 ml of 2,5% solution). The course of treatment - 10-30 injections.

Side effects:

Allergic reactions are possible (skin itching, urticaria, Quincke edema, anaphylactic shock), increased sweating, tachycardia, sometimes soreness at the injection site (due to low pH of the solution).

Interaction:

It is not recommended simultaneous parenteral administration of thiamine and pyridoxine (vitamin B6) or cyanocobalamin (vitamin B12). B12 increases the allergic effect of thiamine. In 6, it makes it difficult to convert thiamine into a biologically active form. Do not mix in one syringe thiamine and benzylpenicillin or streptomycin (destruction of antibiotics), thiamine and nicotinic acid (destruction of thiamine).

Thiamine reduces the pharmacological activity of suxamethonium iodide, phentolamine, propranolol, sympatholytics (reserpine), hypnotics (hypnotics and hypotensive effects are reduced).

Thiamine solution should not be mixed with solutions containing sulfites, t. in them it completely disintegrates.

Thiamine is unstable in alkaline and neutral solutions; the appointment with carbonates, citrates, barbiturates, copper preparations is not recommended.

Weaken the effect of depolarizing muscle relaxants (suxamethonium iodide and etc.)

Special instructions:

When determining theophylline in the blood serum by the spectrophotometric method, urobilinogen with the help of Ehrlich reagent can distort the results (when taking high doses).

Parenteral administration is recommended only if oral administration (nausea, vomiting, malabsorption syndrome, preoperative and / or postoperative conditions) is not possible.

With Wernicke's encephalopathy, the administration of thiamine should precede the intravenous administration of dextrose.

Children use low dosages (0.0125 g thiamine chloride, ie 0.5 ml 2.5% solution).

Form release / dosage:

Solution for intramuscular injection 50 mg / ml.

Packaging:

Solution for intramuscular injection 50 mg / ml.

Ampoules of 1 or 2 ml. For 10 ampoules with instructions for use, a knife or scarifier ampoule if necessary in a pack or box of cardboard. For 5 or 10 ampoules in a planar cell package (1 or 2 contour packs with instructions for use, a knife or a scarifier ampoule if necessary in a cardboard bundle).

Storage conditions:

Store in a place protected from light and inaccessible to children at a temperature of 15 to 25 ° C.

Shelf life:

3 years.

Do not use after expiry date.

Terms of leave from pharmacies:On prescription

Registration number:LSR-003492/08

Date of registration:05.05.2008

The owner of the registration certificate:MICROGEN FGUP Scientific and Production Association MICROGEN FGUP Scientific and Production Association Russia

Manufacturer: & nbsp

MICROGEN FGUP NGO Russia

Representation: & nbspMICROGEN FGUP Scientific and Production Association MICROGEN FGUP Scientific and Production Association Russia

Information update date: & nbsp26.08.2015

Illustrated instructions

Instructions

Thiamine (Thiamine)