Thiamine Vial (Thiamine-Vial)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceThiamineThiamine
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    • Dosage form: & nbspsolution for intramuscular injection
    Composition:
    In 1 ml:
    Active components:
    thiamine hydrochloride 50 mg
    Excipients: sodium chloride, edetic acid
    (ethylenediaminetetraacetic acid), water for injection.

    Description:
    Transparent colorless or slightly yellowish liquid with a weak characteristic odor.

    Pharmacotherapeutic group:vitamin
    ATX: & nbsp

    A.11.D.A.01   Thiamine

    Pharmacodynamics:
    Vitamin B1 (thiamine) refers to water-soluble vitamins. In the human body, as a result of phosphorylation processes, it turns into cocarboxylase, which is a coenzyme of many enzymatic reactions.It plays an important role in the carbohydrate, protein and fat metabolism, in the processes of conduction of nervous excitation in the synapses.

    Pharmacokinetics:
    . In the blood, the concentration is relatively low, while the plasma circulates predominantly free thiamine, in erythrocytes and leukocytes - its phosphoric esters. Phosphorylation occurs in the liver. The most active phosphoric ester is thiamine diphosphate, which has coenzymic activity. It accumulates mainly in the liver, heart, brain, kidneys, spleen. 1/2 of the total is contained in striated muscle and myocardium and about 40% in internal organs. It is excreted through the intestines and kidneys.

    Indications:
    Hypovitaminosis and vitamin B1.
    In complex therapy:
    neuritis, sciatica; neuralgia; peripheral paresis and paralysis;
    - ulcer disease of the stomach and duodenum; decrease in secretory and motor function of the stomach, anorexia, intestinal atony; atonic constipation;
    - Myocardial dystrophy; violation of the coronary circulation;
    -diabetes;
    dermatoses (eczema, neurodermatitis, psoriasis, lichen planus) with neurotrophic changes and metabolic disorders.

    Contraindications:
    Increased individual sensitivity.

    Carefully:
    encephalopathy Wernicke, women in premenopausal and climacteric periods

    Dosing and Administration:
    Thiamine solution is administered intramuscularly (deep into the muscle).
    Begin the administration of the drug is recommended from small doses (no more than 0.5 ml of 5% (50 mg / ml) solution) and only with good tolerance go to higher doses.
    Adults appoint 25-50 mg thiamine chloride (0.5 ml or 1 ml of 5% (50 mg / ml) solution) 1 time per day, daily. The course of treatment - 10-30 injections.

    Side effects:
    Allergic reactions are possible (skin itching, urticaria, Quincke edema, anaphylactic shock), increased sweating, tachycardia, sometimes soreness at the injection site (due to low pH of the solution).

    Interaction:
    It is not recommended simultaneous parenteral administration of thiamine and pyridoxine (vitamin B6) or cyanocobalamin (vitamin B12). B12 increases the allergic effect of thiamine. B6 makes it difficult to convert thiamine into a biologically active form. Do not mix vitamin B1 in one syringe and benzylpenicillin or streptomycin (destruction of antibiotics), vitamin B1 and nicotinic acid (destruction of vitamin B1).
    Thiamine reduces the pharmacological activity of suxamethonium iodide, phentolamine, propranolol, sympatholytics (reserpine), hypnotics (hypnotics and hypotensive effects are reduced).
    Thiamine solution should not be mixed with solutions containing sulfites, t. in them it completely disintegrates.
    Thiamine is unstable in alkaline and neutral solutions; the appointment with carbonates, citrates, barbiturates, copper preparations is not recommended.

    Special instructions:
    When determining theophylline in the blood serum by the spectrophotometric method, urobilinogen with the help of Ehrlich reagent can distort the results (when taking high doses).
    With encephalopathy Wernicke, the appointment of dextrose should precede the administration of thiamine.

    Form release / dosage:
    Solution for intramuscular injection 50 mg / ml.

    Packaging:
    Solution for intramuscular injection 50 mg / ml.
    1 ml into ampoules of yellow glass. For 10 ampoules together with instructions for use in a cardboard bundle.

    Storage conditions:
    In the dark place at a temperature of no higher than 25 ° C.
    Keep out of the reach of children.

    Shelf life:
    3 years.
    Do not use after expiry date.

    Terms of leave from pharmacies:On prescription
    Registration number:LSR-002679/07
    Date of registration:14.09.2007
    The owner of the registration certificate:VIAL, LLC VIAL, LLC Russia
    Manufacturer: & nbsp
    Representation: & nbspVIAL, LLCVIAL, LLC
    Information update date: & nbsp26.08.2015
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