Thiamine - instructions for use, dose, side effects, contraindications

Vitamin B1. In organism; is converted into an active thiamine pyrophosphate and as a coenzyme is included in the pyruvate decarboxylase, alpha-ketoglutarate decarboxylase complexes that participate in the oxidative decarboxylation of pyruvic-alpha-ketoglutaric acids; transketolase-enzyme pentose phosphate shunt. . '

Pharmacokinetics:

In the blood, the concentration is relatively low, while the plasma circulates predominantly free thiamine, in erythrocytes and

leukocytes - its phosphoric esters. Phosphorylation occurs in the liver. The most active phosphoric ester is thiamine diphosphate, which has coenzyme activity. It accumulates mainly in the liver, heart, brain, kidneys, spleen: 1/2 of the total amount is contained in the striated muscle and myocardium and about 40% in the internal organs. It is excreted through the intestines and kidneys.

Indications:Hypovitaminosis and vitamin B1, incl. in patients on probing, hemodialysis, with malabsorption syndrome

Contraindications:

Hypersensitivity to the components of the drug.

Children should not use a 5% solution, because low dosages are used for this category of patients (0.0125 g of thiamine hydrochloride, ie 0.5 ml of a 2.5% solution).

Carefully:Encephalopathy Wernicke, women in.premenopausal and climacteric periods.

Pregnancy and lactation:It is possible to use thiamine during pregnancy and during breastfeeding according to the indications.

Dosing and Administration:

Thiamine solution is administered intramuscularly (deep into the muscle).

, Initiate the drug is recommended with small doses (no more than 0.5 ml of a 5% solution) and only with good tolerance go to higher doses.

Adults appoint 25-50 mg thiamine chloride (0.5 ml or 1 ml of 5%.

solution) 1-times a day, daily, switching to oral administration.

The course of treatment - 10-30 injections.

Side effects:

There are allergic reactions (itching, hives,

angioedema, anaphylactic shock), increased sweating, tachycardia

Soreness at the injection site (due to low pH of the solution).

Interaction:

Interaction with other drugs Not recommended, simultaneous parenteral administration of thiamine and pyridoxine or cyanocobalamin. Cyanocobalamin enhances the allergenic effect of thiamine. Pyridoxine makes it difficult to convert, thiamine into a biologically active form. Do not mix in a single syringe, thiamine and benzylpenicillin or streptomycin (destruction of antibiotics), thiamine and nicotinic acid (destruction of thiamine). Thiamine reduces the pharmacological activity of salts of suxamethonium, phentolamine, propranolol, sympatholytics, (reserpine), hypnotics (hypnotics and hypotensive effects are reduced).

Thiamine solution, should not be mixed with solutions containing sulfites, t. in them it completely disintegrates.

Thiamin is unstable, in alkaline and neutral solutions; appointment with carbonates, citrates, barbiturates; with copper

recommended.

Special instructions:

When determining theophylline in serum by spectrophotometric method, urobilinogen with. the reagent 'Ehrlich can distort' the results (when taking high doses). More often the anaphylactic reaction develops after intravenous administration of large doses.

Parenteral administration is recommended only if oral administration (nausea, vomiting, syndrome, malabsorption ;, preoperative and / or postoperative conditions) is not possible.

With encephalopathy Wernicke, the appointment of dextrose should be administered to thiamine.

Effect on the ability to drive transp. cf. and fur:

On the adverse effects of the drug on, - the ability to - manage

car and other: activities that require concentration

attention and speed of psychomotor reactions were not reported. -

Form release / dosage:

Solution for intramuscular injection 50 mg / ml.

Packaging:

1 ml or 2 ml into neutral glass ampoules.

For 10 ampoules with instruction for use and a knife for opening ampoules or a scarifier ampullum is placed in a box of cardboard.

5 or 10 ampoules are placed in a contoured cell pack of a polyvinylchloride film, or polyethylene terephthalate and aluminum foil or paper with or without polyethylene coating or without paper. For 1 or 2 contour cells with instructions for use and a knife for opening ampoules or a scarifier ampoule placed in a pack of cardboard.

At packing ampoules with a ring of a break or. A fracture point the opener for opening ampoules or scarifier ampoule does not put.

Storage conditions:

In the dark place at a temperature of 15 to 25 ° C.

Keep out of the reach of children.

Shelf life:

. Zgoda

Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:P N000745 / 01

Date of registration:20/06/2011

The owner of the registration certificate:NOVOSIBHIMFARM, OJSC NOVOSIBHIMFARM, OJSC Russia

Manufacturer: & nbsp

NOVOSIBHIMFARM, OJSC Russia

Representation: & nbspNOVOSIBHIMFARM, OJSCNOVOSIBHIMFARM, OJSC

Information update date: & nbsp26.08.2015

Illustrated instructions

Instructions

Thiamine (Thiamine)