. In the blood, the concentration is relatively low, while the plasma circulates predominantly free
thiamine, in erythrocytes and leukocytes - its phosphoric esters. Phosphorylation occurs in the liver. The most active phosphoric ester is thiamine diphosphate, which has coenzymic activity. It accumulates mainly in the liver, heart, brain, kidneys, spleen. In g of the total amount is contained in the striated muscle and myocardium and about 40% in the internal organs. It is excreted through the intestine and
kidneys.