Thiamine - instructions for use, dose, side effects, contraindications

Vitamin B1 (thiamine) refers to water-soluble vitamins. In the human body, as a result of phosphorylation processes, it turns into cocarboxylase, which is a coenzyme of three enzymatic reactions.It plays an important role in the carbohydrate, protein and fat metabolism, in the processes of conduction of nervous excitation in the synapses.

Pharmacokinetics:

In the blood, the concentration is relatively low, while the plasma circulates predominantly free thiamine, in erythrocytes and leukocytes - its phosphoric esters. Phosphorylation occurs in the liver. The most active phosphoric ester is thiamine diphosphate, which has coenzyme activity. It accumulates mainly in the liver, heart, brain, kidneys, spleen. 1/2 of the total amount is contained in striated muscles and myocardium and about 40% in internal organs. It is excreted through the intestines and kidneys.

Indications:

Hypovitaminosis and vitamin B1.

In complex therapy:

neuritis, sciatica; neuralgia; peripheral paresis and paralysis;

- ulcer disease of the stomach and duodenum; decrease in secretory and motor function of the stomach, anorexia, intestinal atony; atonic constipation;

- Myocardial dystrophy; violation of the coronary circulation;

" -diabetes;

dermatoses (eczema, neurodermatitis, psoriasis, lichen planus) with neurotrophic changes and metabolic disorders.

Contraindications:

Increased individual sensitivity.

Carefully:encephalopathy Wernicke, women in peri- and postmenopausal women

Dosing and Administration:

Thiamine solution 5% is administered intramuscularly (deep into the muscle).

Begin the administration of the drug is recommended with small doses (no more than 0.5 ml of a 5% solution) and only with good tolerance go to higher doses.

Adults appoint 25 - 50 mg of thiamine (0.5 ml or 1 ml of 5% solution) once a day, daily. The course of treatment - 10-30 injections.

Children - 12.5 mg thiamine (0.5 ml 2.5% solution).

Side effects:

Allergic reactions are possible (skin itching, urticaria, Quincke edema, anaphylactic shock), increased sweating, tachycardia, sometimes soreness at the injection site (due to low pH of the solution).

Interaction:

It is not recommended simultaneous parenteral administration of thiamine and pyridoxine (vitamin B6) or cyanocobalamin (vitamin B12). Cyanocobalamin enhances the allergenic effect of thiamine. Pyridoxine makes it difficult to convert thiamine into a biologically active form. Do not mix in one syringe thiamine and benzylpenicillin or streptomycin I (destruction of antibiotics), thiamine and nicotinic acid (destruction of thiamine).

Thiamine reduces the pharmacological activity of suxamethonium iodide, phentolamine, propranolol, sympatholytics (reserpine), hypnotics (the hypnotic effect decreases).

Thiamine solution should not be mixed with solutions containing sulfites, t. in them it completely disintegrates.

Thiamine is unstable in alkaline and neutral solutions; the appointment with carbonates, citrates, barbiturates, copper preparations is not recommended.

Special instructions:

When determining theophylline in the blood serum by the spectrophotometric method, urobilinogen with the help of Ehrlich reagent can distort the results (when taking high doses). More often the anaphylactic reaction develops after intravenous administration of large doses.

Parenteral administration is recommended only if oral administration (nausea, vomiting, malabsorption syndrome, preoperative and / or postoperative conditions) is not possible.

With encephalopathy Wernicke, the appointment of dextrose should precede the administration of thiamine.

Effect on the ability to drive transp. cf. and fur:

On the adverse effect of the drug on the ability to drive and engage in other types of activitiesactivities requiring concentration of attention and speed of psychomotor reactions were not reported.

Form release / dosage:

Solution for intramuscular injection 25 mg / ml and 50 mg / ml.

Packaging:

Solution for intramuscular injection 25 mg / ml and 50 mg / ml.

1 ml or 2 ml into neutral glass ampoules.

The ampoules are labeled with self-adhesive labels or the label text is applied directly to ampoules by intaglio printing. For 10 ampoules together with instructions for use and a knife for opening ampoules or a scarifier ampoule in a box of cardboard.

A box is pasted with a label-parcel post.

5 ampoules per contour cell packaging made of polyvinylchloride film and aluminum foil printed lacquered, or without foil. 2 contoured cell packs together with instructions for use and a knife for opening ampoules or a scarifier ampullum are placed in a pack of cardboard.

When using ampoules with break points or white rings, the ampoule opener or ampoule scaper is allowed not to be poured.

Storage conditions:

In the dark place at a temperature of 15 to 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after the time specified on the package.

Terms of leave from pharmacies:On prescription

Registration number:P N003440 / 01

Date of registration:09.06.2009

The owner of the registration certificate:DALHIMFARM, OJSC DALHIMFARM, OJSC Russia

Manufacturer: & nbsp

DALHIMFARM, OJSC Russia

Representation: & nbspDALHIMFARM, OJSCDALHIMFARM, OJSC

Information update date: & nbsp26.08.2015

Illustrated instructions

Instructions

Thiamine (Thiamine)