Bromhexine - instructions for use, dose, side effects, contraindications

Mucolytic (secretolitic), has an expectorant and weak antitussive effect. Reduces the viscosity of sputum (depolymerizes mukoproteinovye and mucopolysaccharide fibers, increases the serous component of the bronchial secretion); activates ciliated epithelium, increases volume and improves sputum discharge.Stimulates the production of endogenous surfactant, which ensures the stability of alveolar cells in the process of breathing. The effect is manifested after 2-5 days from the beginning of treatment.

Pharmacokinetics:

When ingested almost completely (99%) is absorbed in the gastrointestinal tract (GIT) for 30 minutes. Bioavailability is about 80%. Penetrates through the placental and blood-brain barrier (BBB).

In the liver it is demethylated and oxidized, metabolized to pharmacologically active ambroxol. The half-life (T1 / 2) is 15 hours (due to slow back diffusion from the tissues). It is excreted by the kidneys. In chronic renal failure (CRF), excretion of metabolites is impaired. With multiple applications can cumulate.

Indications:

Acute and chronic diseases of the respiratory tract, accompanied by difficulty in withdrawing viscous sputum: tracheobronchitis, bronchitis of different etiology (including complicated by bronchiectasis), pneumonia, bronchial asthma, pulmonary tuberculosis, cystic fibrosis.

Sanitation of the bronchial tree in the preoperative period and during the medical and diagnostic intrabronchial manipulation, prevention of congestion in the bronchi of thick viscous sputum after the operation.

Contraindications:

Hypersensitivity, peptic ulcer of the stomach and duodenum, pregnancy (I trimester), lactation period, children under 6 years (for syrup 8 mg / 5 ml).

Carefully:

Renal failure, liver failure, bronchial diseases accompanied by excessive accumulation of secretion, in history - gastrointestinal bleeding.

Dosing and Administration:

Inside. 1 measuring spoon or 1 measuring cup contains 5 ml of syrup.

Syrup 8 mg / 5 ml is prescribed for adults and children over 14 years of 8-16 mg (5-10 ml) 3 times a day, children 6-14 years - 8 mg (5 ml) 3 times a day.

Syrup 4 mg / 5 ml is prescribed to children in the following doses: up to 2 years 2 mg (2.5 ml) 3 times a day, 2-6 years - 4 mg (5 ml) 3 times a day, 6-14 years - 8 mg (10 ml) 3 times a day.

Side effects:

Allergic reactions, nausea, vomiting, dyspepsia, exacerbation of peptic ulcer of stomach and duodenum, dizziness, headache, increased activity of "liver" transaminases (extremely rare).

Overdose:

Symptoms: nausea, vomiting, diarrhea and other dyspeptic disorders.

Treatment: artificial vomiting, gastric lavage (in the first 1-2 hours after administration).

Interaction:

Do not prescribe concomitantly with drugs that suppress the cough center (incl. codeine), t. this makes it difficult for the diluted sputum to escape (accumulation of bronchial secretion in the respiratory tract).

Incompatible with alkaline solutions. Bromhexine promotes the penetration of antibiotics, sulfonamides into the bronchial secret in the first 4-5 days of antimicrobial therapy.

Special instructions:

During treatment, it is necessary to use a sufficient amount of liquid, which increases the expectorant effect of bromhexine.

Treatment should be combined with postural drainage or vibration massage of the chest, facilitating the removal of secretions from the bronchi.

Bromhexine sugar-free, the syrup contains sweeteners, so it can be used in patients with diabetes, obesity.

Form release / dosage:

Syrup 8 mg / 5 ml or syrup 4 mg / 5 ml.

Packaging:Syrup for oral intake of 50 ml or 100 ml in bottles of dark color from polyethylene terephthalate or glass. Each bottle is placed along with the instructions for use, a measuring spoon for 5 ml or a measuring cup of 5 ml into individual cardboard packs.

Storage conditions:

Store in a dry place protected from light, at a temperature not lower than 15 ° С.

Keep out of the reach of children.

Shelf life:

3 years. Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-006000/10

Date of registration:25.06.2010 / 15.01.2016

Expiration Date:Unlimited

The owner of the registration certificate:ROSLEKS PHARM, LLCROSLEKS PHARM, LLC Russia

Manufacturer: & nbsp

ROSLEKS PHARM, LLC Russia

Information update date: & nbsp25.02.2017

Illustrated instructions

Instructions

Bromhexine (Bromhexine)