Solvine - instructions for use, dose, side effects, contraindications

lactose - 60.30 mg, corn starch - 55.975 mg, acacia gum - 2.125 mg, methyl parahydroxybenzoate - 0.13 mg, propyl parahydroxybenzoate - 0.07 mg, dye sunset yellow - 0.15 mg, gelatin 1.75 mg, talcum - 4,00 mg, silicon dioxide colloid -2,00 mg, magnesium stearate - 0,50 mg.

Description:Round, flat-cylindrical tablets from light orange to orange, it is admissible to have inclusions of a lighter and darker color, with a facet and a risk on one side.

Pharmacotherapeutic group:expectorant mucolytic

ATX: & nbsp

R.05.C.B Mucolytics

R.05.C.B.02 Bromhexine

Pharmacodynamics:The drug has mucolytic (secretolitic) and expectorant action. Mucolytic effect is associated with depolimiracisation and liquefaction of mucoprotein and mucopolysaccharide fibers. The effect is manifested after 2-5 days from the beginning of treatment. Stimulates the production of endogenous surfactant, which ensures the stability of alveolar cells in the process of breathing.

Pharmacokinetics:When ingested almost completely (99%) is absorbed in the gastrointestinal tract for 30 minutes. Bioavailability is about 80%. Penetrates through the placental and hemato-encephalic barrier. In the liver it undergoes demethylation and oxidation, it is metabolized to ambroxol. The half-life (T 1/2) is 15 hours (due to slow reversible diffusion from the tissues). It is excreted by the kidneys. With chronic renal failure, the release of metabolites is disrupted. With multiple applications can cumulate.

Indications:Acute and chronic lung diseases accompanied by the formation of sputum of increased viscosity (bronchial asthma, cystic fibrosis, tuberculosis, pneumonia, tracheobronchitis, obstructive bronchitis, bronchiectasis, pulmonary emphysema, pneumoconiosis), chest trauma.

Contraindications:

hypersensitivity to the components of the drug, including lactose;
pregnancy;
lactation period;
stomach ulcer;
children's age up to 3 years.
rare hereditary diseases, such as galactose intolerance, lactase deficiency or glucose-galactose malabsorption (because the preparation contains lactose).

If any of these cases apply to you, consult your doctor before taking the drug.

Carefully:Bromhexine should be used with caution weakened patient, as well as patients with bronchial diseases, accompanied by excessive accumulation of secretions; gastric bleeding in history, renal and / or hepatic insufficiency.

Dosing and Administration:

Solvin® is taken orally regardless of the meal. During the treatment it is recommended to use a sufficient amount of liquid that supports the secretolitic action of bromhexine. The course of treatment is from 4 to 28 days.

Adults appoint 8-16 mg 3-4 times a day; children from 3 to 5 years - 4 mg 3 times a day, from 6 to 14 years - 4-8 mg 3 times a day.

Children up to 6 years of age are recommended to take Solvin®, a solution for oral administration.

In children, treatment should be combined with postural drainage or vibration massage of the chest, facilitating the evacuation of secretions from the bronchi.

Side effects:

Rarely, with prolonged use of the drug, nausea, vomiting, dyspepsia, peptic ulcer, allergic reactions (skin rash, face swelling, rhinitis, etc.), dizziness, headache, increased activity of "liver" transaminases are possible. In these cases, the drug should be discontinued.

If you have similar or other symptoms not listed above, consult a doctor about further taking the drug!

Overdose:

Symptoms: nausea, vomiting, diarrhea, dyspeptic disorders.

Treatment: artificial vomiting, gastric lavage (in the first 1-2 hours after administration).

Interaction:

Bromhexine can be administered simultaneously with other drugs used in the treatment of bronchopulmonary diseases.

Bromhexine is not prescribed concomitantly with drugs containing codeine, as this makes it difficult to cough up thinned phlegm.

Bromhexine promotes the penetration of antibiotics (amoxicillin, erythromycin, cephalexin, oxytetracycline), sulfonamide drugs in the bronchial secret in the first 4-5 days of antimicrobial therapy.

The combined use of bromhexine with certain non-steroidal anti-inflammatory drugs (for example, salicylates, phenylbutazone or butadione) can cause irritation of the gastric mucosa.

Bromhexine is not compatible with alkaline solutions.

Before you start taking Solvin, consult your doctor if you are taking other medications.

Special instructions:

When treating, you must take a sufficient amount of fluid, which increases the expectorant effect of bromhexine.

In children, treatment should be combined with postural drainage or vibratory chest massage, which facilitates the secretion of bronchial secretions.

Effect on the ability to drive transp. cf. and fur:

There is no information about the adverse effects of bromhexine on the ability to drive vehicles and service mechanisms. In case of development of undesirable reactions due to the use of the drug, one should refrain from managing the vehicles and servicing the mechanisms.

Form release / dosage:

Tablets 8 mg.

Packaging:

10 tablets in an aluminum foil / PVC blister.

10 blisters in a cardboard box together with instructions for use.

Storage conditions:

Store in a dry, dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

4 years.

Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:П N014832 / 01

Date of registration:30.05.2008

The owner of the registration certificate:Ipka Laboratories Ltd.Ipka Laboratories Ltd. India

Manufacturer: & nbsp

IPCA LABORATORIES, Ltd. India

Information update date: & nbsp08.12.2015

Illustrated instructions

Instructions

Solvin® (Solvin)