Bromhexine - instructions for use, dose, side effects, contraindications

Excipients: propylene glycolring - 1250.0 mg, sorbitol (sorbitol) - 2000.0 mg, succinic acid 12.5 mg, eucalyptuslenta leaf-shaped oil (eucaLipton oil) - 0.75 mg, sodium benzoate - 2.5 mg, apricot flavor or cherry flavor, or pear flavoring - 5.0 mg, water (purified water) - up to 5 ml.

Description:

Colorless or slightly yellowish liquid with a fruity odor.

Pharmacotherapeutic group:Expectorant mucolytic agent

ATX: & nbsp

R.05.C.B Mucolytics

R.05.C.B.02 Bromhexine

Pharmacodynamics:

The drug has mucolytic (secretolitic), expectorant and weak antitussive effect.Mucolytic effect is associated with depolymerization and liquefaction of mucoprotein and mucopolysaccharide fibers, as well as with an increase in the amount of serous bronchial secretion. Bromhexine increases the activity of the ciliated epithelium, improves the sputum discharge. Stimulates the production of endogenous surfactant, which ensures the stability of alveolar cells in the process of breathing. Clinical effect is manifested after 2-5 days from the beginning of treatment with the drug.

Pharmacokinetics:

Ingestion bromohexine almost completely (99%) is absorbed within 30 minutes. Bioavailability is 80% (the effect of "first passage" through the liver). In the plasma bromohexine binds to proteins, penetrates through blood-brain and placental barriers.

Metabolized in the liver by demethylation and oxidation, with the formation of pharmacologically active metabolite - ambroxol.

The half-life (T1 / 2) is 15 hours due to slow back diffusion from the tissues. To be excreted by the kidneys. In chronic renal failure, the release of metabolites of bromhexine is disrupted. With repeated use, cumulation of the drug is possible.

Indications:

Diseases of the respiratory system, accompanied by the formation of hard-to-remove viscous sputum: tracheobronchitis, bronchitis (various etiologies, including bronchitis complicated by bronchiectasis), pneumonia (acute and chronic), cystic fibrosis, bronchial asthma, pulmonary tuberculosis.

Sanitation of the bronchial tree in the preoperative period, postoperative period (prevention of congestion of viscous sputum), as well as during intrabronchial manipulations (diagnostic or therapeutic).

Contraindications:

hypersensitivity to the components of the drug;
hereditary intolerance to fructose (due to the presence of sorbitol in the formulation);
peptic ulcer (at the stage of exacerbation);
pregnancy (I trimester);
lactation period.

Carefully:

- Diseases of the bronchi accompanied by excessive accumulation of secretions;

- renal and / or hepatic impairmentnost;

- the presence of a history of gastric bloodflow.

Dosing and Administration:

Bromhexine take inside independentlymo from eating.

Adults and children over the age of 14 appointing8-16 mg (10-20 ml) 3-4 times a day.

Children under 2 years of age - 2 mg each (2.5 ml) 3 times a day, from 2 to 6 years - 4 mg (5 ml) 3 times a day, 6 to 14 years - 8 mg (10 ml) 3 times a day.

For accurate dosing of the drug inof the proposed equipment use a measuring spoon or a measuring syringe, enclosed in the package.

In the case of a measuring syringe:

Open the lid of the vial.
Tightly insert a measuring syringe into the hole of the adapter installed in the neck of the vial.
Turn the bottle upside down and gently pull the piston downward, picking up the syrup into a measuring syringe to the desired mark.
Return the bottle to its original position and remove the measuring syringe, gently rotating it.
Give the medication to the child inside by means of a measuring syringe. To ensure a smooth intake of the syrup into the mouth, slowly press the plunger.
After each use, wash the measuring syringe in running water and dry it in disassembled form at room temperature in a place inaccessible to the child. Store the measuring syringe in the package with the drug.

Patients with renal insufficiency are prescribed smaller doses or increase the interval between taking the drug.

Side effects:

Allergic reactions, dyspeptic phenomena (nausea, vomiting), dizziness, headache, exacerbation of peptic ulcer of the stomach and duodenum, increased activity of "liver" transaminases.

Flatulence, diarrhea, weakness, hyperglycemia (in patients with decompensated diabetes mellitus) - in connection with the presence of the drug sorbitol.

Overdose:

Symptoms: dyspeptic disorders, including nausea, vomiting, diarrhea.

Treatment: artificial vomiting, gastric lavage (in the first 1-2 hours after administration).

Interaction:

Bromhexine can be administered simultaneously with other drugs used in the treatment of bronchopulmonary diseases.

Bromhexine Do not prescribe concomitantly with drugs that suppress the cough center (including those containing codeine), as this makes it difficult to cough up thinned phlegm.

Bromhexine contributes to the penetration of antibiotics (amoxicillin, erythromycin, cephalexin, oxytetracycline) and sulfonamide drugs in the bronchial secret in the first 4-5 days of antimicrobial therapy.

Bromhexine not compatible with alkaline solutions.

Special instructions:

During the treatment it is recommended to use a sufficient amount of liquid, which increases the secretion and expectorant action of bromhexine.

In children, treatment should be combined with postural drainage or vibration massage of the chest, facilitating the evacuation of secretions from the bronchi.

If there is no effect within 4-5 days, a doctor's consultation is necessary.

In 5 ml of syrup contains 2 g of sorbitol, which corresponds to 0.17 bread units.

Effect on the ability to drive transp. cf. and fur:

The drug does not affect the ability to management of vehicles and various mechanisms, as well as to employmentother potentially dangerous Activities that require increased attention and speed of mental and motor reactions.

Form release / dosage:

Syrup [apricot, cherry, pear4 mg / 5 ml.

Packaging:

100 ml of syrup in dark vials glass. One bottle with instruction for application and measuring spoon or dimensional The syringe is placed in a pack of cardboard.

Storage conditions:

Store at a temperature not exceeding 25 ° C. Keep out of the reach of children.

Shelf life:

3 years.Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:P N001291 / 02

Date of registration:23.07.2008 / 18.10.2013

Expiration Date:Unlimited

The owner of the registration certificate:PHARMSTANDART-FORESTRY, OJSC PHARMSTANDART-FORESTRY, OJSC Russia

Manufacturer: & nbsp

PHARMSTANDART-FORESTRY, OJSC Russia

Information update date: & nbsp25.02.2017

Illustrated instructions

Instructions

Bromhexine (Bromhexine)