Bromhexine MS - instructions for use, dose, side effects, contraindications

The drug has mucolytic (secretolitic) and expectorant action. Mucolytic effect is associated with depolymerization and liquefaction of mucoprotein and mucopolysaccharide fibers. Bromhexine has a weak antitussive effect.

Reduces the viscosity of sputum, increases the serous component of bronchial secretion; activates ciliated epithelium, increases volume and improves sputum discharge. Stimulates the production of endogenous surfactant, which ensures the stability of alveolar cells in the process of breathing. The effect is manifested after 2-5 days from the beginning of treatment.

Pharmacokinetics:

Ingestion bromohexine almost completely (99%) is absorbed within 30 minutes. Bioavailability is 80% due to the effect of "first passage" through the liver. In the plasma bromohexine binds to proteins, penetrates through blood-brain and placental barriers. In the liver bromohexine is subjected to demethylation and oxidation. The half-life is 15 hours due to slow reverse diffusion from the tissues. Excreted by the kidneys. In chronic renal failure, the release of metabolites of bromhexine is disrupted. With repeated use bromohexine can cumulate.

Indications:

Bromhexine apply:

treatment of bronchopulmonary diseases accompanied by the formation of sputum of increased viscosity (bronchial asthma, cystic fibrosis, tuberculosis, pneumonia, tracheobronchitis, obstructive bronchitis, bronchiectasis, pulmonary emphysema, pneumoconiosis);
sanation of the bronchial tree in the preoperative period and during the treatment and diagnostic intrabronchial manipulation;

prevention of congestion in the bronchi of thick viscous sputum after surgery.

Contraindications:

hypersensitivity to the components of the drug;
peptic ulcer of stomach in the stage of exacerbation;
pregnancy (I trimester);
lactation period;
children's age till 6 years.

Carefully:

renal and / or liver failure;
bronchial diseases accompanied by excessive accumulation of secretions;
in the anamnesis - gastric bleeding.

Dosing and Administration:

Bromhexine take inside regardless of food intake. Adults and children over 14 years of age are prescribed 1 - 2 tablets (8-16 mg) 3-4 times a day; children from 6 to 14 years, 1 tablet (8 mg) 3 times a day. The course of treatment is from 4 to 28 days.

During the treatment it is recommended to use a sufficient amount of liquid that supports the secretolitic action of bromhexine.

Side effects:

Rarely, with prolonged use of the drug.

From the skin: Allergic reactions are possible (skin rash).

From the digestive tract: nausea, vomiting, dyspepsia, exacerbation of gastric ulcer and duodenal ulcer, increased level of hepatic transaminases in blood serum.

From the respiratory system: allergic reactions (rhinitis).

In these cases, the drug should be discontinued.

Overdose:

Symptoms: dyspeptic disorders, incl. nausea, vomiting, diarrhea.

Treatment: artificial vomiting, gastric lavage (in the first 1-2 hours after administration).

Interaction:

Bromhexine Do not prescribe concomitantly with drugs containing codeine, since this makes it difficult to cough up thinned phlegm.

Bromhexine contributes to the penetration of antibiotics (amoxicillin, erythromycin, cephalexin, oxytetracycline), sulfonamide drugs in the bronchial secret in the first 4-5 days of antimicrobial therapy.

Incompatible with alkaline solutions.

Form release / dosage:

Tablets 8 mg.

Packaging:

For 10 tablets in a planar cell package.

For 20, 50 or 100 tablets in a polymer can.

Each jar or 1, 2, 5, 10 contour mesh packages together with the instructions for use are placed in a bundle.

It is allowed to place contour packs together with an equal number of instructions for use ingroup packing.

Storage conditions:

List B. In a dry, the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use the product after the expiry date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:P N002016 / 01

Date of registration:27.01.2009

Expiration Date:Unlimited

The owner of the registration certificate:MEDISORB, CJSC MEDISORB, CJSC Russia

Manufacturer: & nbsp

MEDISORB, CJSC Russia

Information update date: & nbsp25.02.2017

Illustrated instructions

Instructions

Bromhexine MS (Bromhexine MS)