Bromhexine - instructions for use, dose, side effects, contraindications

1 tablet contains: active substance: bromhexine hydrochloride - 8 mg; auxiliary substances: lactose monohydrate 112 mg, potato starch 52 mg, sucrose (sugar) 26 mg, calcium stearate 2 mg.

Description:Tablets of white or almost white color, round, flat-cylindrical with a facet and a risk

Pharmacotherapeutic group:Mucolytic and expectorant

ATX: & nbsp

R.05.C.B Mucolytics

R.05.C.B.02 Bromhexine

Pharmacodynamics:

The drug has mucolytic (secretolitic) and expectorant action. Mucolytic effect is associated with depolymerization and liquefaction of mucoprotein and mucopolysaccharide fibers, Bromhexine has a weak antitussive effect.Stimulates the production of endogenous surfactant, which ensures the stability of alveolar cells in the process of breathing. Clinical effect is manifested after 2-5 days from the beginning of treatment with the drug.

Pharmacokinetics:

When ingested almost completely (99%) is absorbed within 30 minutes. About 80% of bromhexine undergoes intensive metabolism due to "first passage through the liver." In the plasma bromohexine binds to proteins, penetrates through blood-brain and placental barriers. In the liver bromohexine is demethylated and oxidized to form an active metabolite - ambroxol. The half-life is 15 hours due to slow reverse diffusion from the tissues. It is excreted by the kidneys. In chronic renal failure, excretion of metabolites of bromhexine is impaired. With repeated use bromohexine can cumulate.

Indications:

Bronchopulmonary diseases accompanied by the formation of sputum of increased viscosity (bronchial asthma, cystic fibrosis, pulmonary tuberculosis, pneumonia, tracheobronchitis, obstructive bronchitis, bronchiectasis, pulmonary emphysema, pneumoconiosis).

Contraindications:

Hypersensitivity to the drug components, deficiency of lactase, sucrose / isomaltase, lactose intolerance, fructose, glucose-galactose malabsorption, pregnancy (I trimester), breastfeeding period, peptic ulcer (at the stage of exacerbation), children under 6 years.

Carefully:With gastric bleeding in the history, renal and / or liver failure, bronchial diseases, accompanied by excessive accumulation of secretions.

Pregnancy and lactation:The use of the drug in the first trimester of pregnancy and during breastfeeding is contraindicated. If you need to use the drug during breastfeeding, breastfeeding should be discarded.

The use of the drug in the II-III trimester of pregnancy is possible if the expected benefit for the mother exceeds the potential risk to the fetus.

Dosing and Administration:

Inside, regardless of food intake.

Adults and children over 14 years of age - 8-16 mg 3-4 times a day.

Children aged 6 to 14 years - 8 mg 3 times a day.

The course of treatment is from 4 to 28 days,

Side effects:

Rarely, with prolonged reception of the drug are possible: allergic reactions, skin rash, rhinitis.

From the side of the central nervous system: dizziness, headache.

On the part of the digestive system: dyspeptic phenomena, exacerbation of peptic ulcer of the stomach and duodenum, increased activity of "liver" transaminases in the blood serum.

In these cases, the drug should be discontinued.

If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose:

Symptoms: nausea, vomiting, diarrhea.

Treatment: artificial vomiting, gastric lavage (in the first 1-2 hours after administration).

Interaction:

Bromhexine is not prescribed concomitantly with drugs that suppress the cough center (including those containing codeine), as this makes it difficult to evacuate diluted sputum.

Bromhexine promotes the penetration of antibiotics (amoxicillin, erythromycin, cephalexin, oxytetracycline), sulfonamide drugs in the bronchial secretion.

Bromhexine is not compatible with alkaline solutions.

Special instructions:

During the treatment it is recommended to use a sufficient amount of liquid that supports the secretolitic action of bromhexine.

In children, treatment should be combined with postural drainage or vibration massage of the chest, facilitating the evacuation of secretions from the bronchi.

Effect on the ability to drive transp. cf. and fur:

During the treatment period, care must be taken when driving vehicles and engaging in potentially hazardous activities requiring increased attention and speed of psychomotor reactions.

Form release / dosage:

Tablets 8 mg.

Packaging:

For 10 tablets in a contour mesh box made of polyvinylchloride film and aluminum foil printed lacquered.

By 2, 3, 4, 5 contour mesh packages together with the instruction for use are placed in a pack of cardboard.

Storage conditions:

In a dry, protected from light place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LS-002633

Date of registration:22.03.2012 / 21.01.2014

Expiration Date:Unlimited

The owner of the registration certificate:KIROVSKAYA PHARMACEUTICAL COMPANY, LTD. KIROVSKAYA PHARMACEUTICAL COMPANY, LTD. Russia

Manufacturer: & nbsp

KIROVSKAYA PHARMACEUTICAL COMPANY, LTD. Russia

Representation: & nbspKIROVSKAYA PHARMACEUTICAL FACTORY, OJSCKIROVSKAYA PHARMACEUTICAL FACTORY, OJSC

Information update date: & nbsp25.02.2017

Illustrated instructions

Instructions

Bromhexine (Bromhexine)