Bromhexine - instructions for use, dose, side effects, contraindications

1 tablet contains active ingredient bromhexine hydrochloride - 8 mg. Auxiliary substances: potato starch, lactose (sugar milk), sucrose (sugar), calcium stearate.

Description:

Ploskotsilindricheskie tablets are white, with a bevel.

Pharmacotherapeutic group:Expectorant mucolytic agent

ATX: & nbsp

R.05.C.B Mucolytics

R.05.C.B.02 Bromhexine

Pharmacodynamics:

Mucolytic (secretolitic), has an expectorant and weak antitussive effect. Reduces the viscosity of sputum (depolymerizes mukoproteinovye and mucopolysaccharide fibers, increases the serous component of the bronchial secretion); activates ciliated epithelium, increases volume and improves sputum discharge.Stimulates the production of endogenous surfactant, which ensures the stability of alveolar cells in the process of breathing. The effect is manifested after 2-5 days from the beginning of treatment.

Pharmacokinetics:

Ingestion bromohexine almost completely (99%) is absorbed in the gastrointestinal tract for 30 minutes. Bioavailability is low (the effect of primary "passage" through the liver). Penetrates through blood-brain and placental barriers. In the liver bromohexine is demethylated and oxidized, metabolized to pharmacologically active ambroxol. The half-life is 15 hours (due to slow back diffusion from the tissues). It is excreted by the kidneys. With chronic renal failure, excretion of metabolites is impaired. With repeated use bromohexine can cumulate.

Indications:

Diseases of the respiratory tract, accompanied by difficulty in moving away viscous sputum: tracheobronchitis, bronchitis of different etiology (including complicated by bronchiectasis), bronchial asthma, pulmonary tuberculosis, pneumonia, cystic fibrosis.

Sanitation of the bronchial tree in the preoperative period and during medical and diagnosticintrabronchial manipulation, prevention of congestion in the bronchi of thick viscous sputum after surgery.

Contraindications:

-Increased sensitivity to the components of the drug;

-period of lactation;

- Pregnancy (I trimester);

- ulcer disease (in the stage of exacerbation);

-Children under 6 years.

Carefully:

Gastrointestinal bleeding in history, renal and / or liver failure, bronchial diseases, accompanied by excessive accumulation of secretions.

Dosing and Administration:

Bromhexine take inside regardless of food intake. Adults appoint 8-16 mg 3-4 times a day; children from 6 to 14 years - 8 mg 3 times a day. The course of treatment is from 4 to 28 days.

During the treatment it is recommended to use a sufficient amount of liquid that supports the secretolitic action of bromhexine.

Side effects:

Allergic reactions, dyspepsia, incl. nausea, vomiting; exacerbation of peptic ulcer of stomach and duodenum, dizziness, headache, increased activity of "liver" transaminases.

Overdose:

Symptoms: nausea, vomiting, diarrhea.

Treatment: symptomatic, gastric lavage (in the first 1-2 hours after taking).

Interaction:

Bromhexine can be administered simultaneously with other drugs used in the treatment of bronchopulmonary diseases.

Bromhexine Do not prescribe concomitantly with medicines containing codeine, as this makes it difficult to cough up thinned phlegm.

Bromhexine contributes to the penetration of antibiotics (erythromycin, cephalexin, oxytetracycline) into the lung tissue.

Bromhexine is incompatible with alkaline solutions.

Special instructions:

When treating, you must take a sufficient amount of fluid, which increases the expectorant effect of bromhexine. In children, treatment should be combined with postural drainage or vibratory chest massage, which facilitates the secretion of bronchial secretions.

Form release / dosage:

Tablets 8 mg.

Packaging:

10 or 20 tablets in a planar cell package.

1, 2, 3, 4 or 5 contour mesh packages with instructions for use in a pack of cardboard.

It is allowed to use contour packagings with an equal number of instructions for use in a group pack.

Storage conditions:

Store at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Shelf life:

5 years.Do not use after expiry date.

Terms of leave from pharmacies:Without recipe

Registration number:P N001291 / 01

Date of registration:19.11.2007

Expiration Date:Unlimited

The owner of the registration certificate:PHARMSTANDART-FORESTRY, OJSC PHARMSTANDART-FORESTRY, OJSC Russia

Manufacturer: & nbsp

PHARMSTANDART-FORESTRY, OJSC Russia

Information update date: & nbsp25.02.2017

Illustrated instructions

Instructions

Bromhexine (Bromhexine)