Bromhexine - instructions for use, dose, side effects, contraindications

Mucolytic (secretolitic), has an expectorant and weak antitussive effect. Reduces the viscosity of sputum (depolymerizes mukoproteinovye and mucopolysaccharide fibers, increases the serous component of the bronchial secretion); activates ciliated epithelium, increases volume and improves sputum discharge.Stimulates the production of endogenous surfactant, which ensures the stability of alveolar cells in the process of breathing. The effect is manifested after 2-5 days from the beginning of treatment.

Pharmacokinetics:

When ingested almost completely (99%) is absorbed in the gastrointestinal tract for 30 minutes. Bioavailability is 80%. Penetrates through the placental barrier and the blood-brain barrier (BBB).

In the liver it is subjected to dimethylation and oxidation, it is metabolized to pharmacologically active ambroxol. T1 / 2 - 15 hours (due to slow reverse diffusion from tissues). It is excreted by the kidneys. With chronic renal failure, excretion of metabolites is impaired. With multiple applications can cumulate.

Indications:

Diseases of the respiratory tract, accompanied by difficulty in withdrawing viscous sputum: tracheobronchitis, bronchitis of different etiology (including complicated bronchiectasis), bronchial asthma, pulmonary tuberculosis, pneumonia (acute and chronic), cystic fibrosis.

Sanitation of the bronchial tree in the preoperative period and during the medical and diagnostic intrabronchial manipulation, prevention of congestion in the bronchi of thick viscous sputum after the operation.

Contraindications:

Hypersensitivity, peptic ulcer of the stomach, pregnancy (I trimester); lactation period; children's age (up to 6 years).

Carefully:

Renal and / or liver failure; bronchial diseases, accompanied by excessive accumulation of secretion, in the anamnesis - gastric bleeding.

Dosing and Administration:

Inside adults and children over 14 years - 8-16 mg (1-2 tablets) 3-4 times a day. Children aged 6-14 years - 8 mg (1 tablet) 3 times a day. If necessary, the dose can be increased to 16 mg adults (2 tablets) 4 times a day.

Therapeutic effect may appear on the 4-6th day of treatment.

Patients with renal insufficiency are prescribed smaller doses or increase the interval between administrations.

Side effects:

Allergic reactions, nausea, vomiting, dyspepsia, exacerbation of gastric ulcer and duodenal ulcer, dizziness, headache, increased activity of "liver" transaminases (extremely rare).

Overdose:

Symptoms: nausea, vomiting, diarrhea, dyspeptic disorders.

Treatment: artificial vomiting, gastric lavage (in the first 1-2 hours after administration).

Interaction:

Do not prescribe concurrently with medicines suppressing the cough center (incl. codeine), as this makes it difficult to escape the diluted sputum (accumulation of bronchial secretions in the airways).

Incompatible with alkaline solutions.

Bromhexine contributes to the penetration of antibiotics (amoxicillin, erythromycin, cephalexin, oxytetracycline), sulfonamide drugs in the bronchial secret in the first 4-5 days of antimicrobial therapy.

Special instructions:

When treating, you must take a sufficient amount of fluid, which increases the expectorant effect of bromhexine.

In children, treatment should be combined with postural drainage or vibratory chest massage, which facilitates the secretion of bronchial secretions.

Form release / dosage:

Tablets 8 mg.

Packaging:

By 10, 14, 20, 50 tablets in the contour cell pack of film polyvinylchloride and foil aluminum printed varnished.

2, 5 contour cell packs of 10 tablets or 2 contour packs of 14 tablets with instructions for application is placed in a pack of cardboard.

20 contour cell packs of 10 tablets with an equal number of instructions for use in a pack of cardboard.

Contour-cell packs of 10, 20, 50 tablets with equal amounts instructions for use are placed in a group package.

Storage conditions:

In a dry place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:

3 years. Do not use after the date shown on the package.

Terms of leave from pharmacies:Without recipe

Registration number:P N003110 / 01

Date of registration:11.09.2008 / 18.05.2012

Expiration Date:Unlimited

The owner of the registration certificate:UPDATE OF PFC, CJSC UPDATE OF PFC, CJSC Russia

Manufacturer: & nbsp

UPDATE, PFC CJSC Russia

Representation: & nbspUPDATE OF PFC, CJSCUPDATE OF PFC, CJSC

Information update date: & nbsp25.02.2017

Illustrated instructions

Instructions

Bromhexine (Bromhexine)