Solvine - instructions for use, dose, side effects, contraindications

Excipients: propylene glycol, benzoic acid, citric acid, sorbitol solution, sodium saccharin, menthol, vanillin, dye sunset, essence pineapple, essence sweet orange, purified water.

Description:Light orange transparent liquid, with a mixed menthol-fruity odor.

Pharmacotherapeutic group:mucolytic agent

ATX: & nbsp

R.05.C.B Mucolytics

R.05.C.B.02 Bromhexine

Pharmacodynamics:

The drug has a mucolytic (secretolitic) and expectorant action. Mucolytic effect is associated with the depolymerization and dilution of mucoprotein and mucopolysaccharide fibers. The effect is manifested after 2-5 days from the beginning of treatment.Stimulates the production of endogenous surfactant, which ensures the stability of alveolar cells in the process of breathing.

Pharmacokinetics:

when ingested almost completely (99%) is absorbed in the gastrointestinal tract for 30 minutes. Bioavailability is about 80%. Penetrates through the placental and blood-brain barrier. In the liver it undergoes demethylation and oxidation, it is metabolized to ambroxol. T1 / 2 - 15 hours (due to slow reverse diffusion from tissues). It is excreted by the kidneys. With chronic renal failure, the release of metabolites is disrupted. With multiple applications can cumulate.

Indications:

Acute and chronic lung diseases accompanied by the formation of sputum of increased viscosity (bronchial asthma, cystic fibrosis, tuberculosis, pneumonia, tracheobronchitis, obstructive bronchitis, bronchiectasis, pulmonary emphysema, pneumoconiosis), chest trauma.

Contraindications:

Hypersensitivity to the components of the drug; including lactose.
pregnancy;
lactation period;
stomach ulcer;
children under 3 years old (for tablets)

If any of these cases apply to you, consult your doctor before taking the drug.

Dosing and Administration:

Bromhexine take inside regardless of food intake. In the course of treatment, it is recommended to use a sufficient amount of liquid that supports the secretionolytic action of bromhexine. The course of treatment is from 4 to 28 days.

Patient's age	Dose, teaspoons
Children
up to 2 years	1/2
from 2 to 6 years	½ - 1
from 6 to 14 years	1-2
Adolescents (starting from age 14) and adults	2-3

Children up to 6 years of age are recommended to take the elixir of bromhexine.

Elixir:

In children, treatment should be combined with postural drainage or vibration massage of the chest, facilitating the evacuation of secretions from the bronchi.

Side effects:

Rarely, with prolonged use of the drug, nausea, vomiting, dyspepsia, peptic ulcer, allergic reactions (skin rash, face swelling, rhinitis, etc.) are possible, an increase in the level of transaminases in the blood serum. In these cases, the drug should be discontinued.

If you have similar or other symptoms not listed above, consult a doctor about further taking the drug!

Overdose:

Symptoms: nausea, vomiting, diarrhea, dyspeptic disorders. Treatment: artificial vomiting, gastric lavage (in the first 1-2 hours after administration).

Interaction:

Solvine can be administered simultaneously with other drugs used in the treatment of bronchopulmonary diseases.

Solvine is not prescribed concomitantly with medications containing codeine, as this makes it difficult to cough up thinned phlegm.

Solvin promotes the penetration of antibiotics (erythromycin, cephalexin, oxytetracycline) into the lung tissue.

Joint application of Solvine with some non-steroidal anti-inflammatory drugs (for example, salicylates, phenylbutazone or butadione) can cause irritation of the gastric mucosa.

Solvin is not compatible with alkaline solutions.

Before starting to take Solvyn, consult a doctor if you are taking other medications.

Special instructions:

Solvin should be used with caution by the weakened patient, as well as patients with bronchial diseases accompanied by excessive accumulation of secretions; gastric bleeding in history, renal and / or hepatic insufficiency.

Effect on the ability to drive transp. cf. and fur:

There is no information about the adverse effects of bromhexine on the ability to drive vehicles and service mechanisms.

Form release / dosage:

Elixir.

Packaging:

Elixir: 120 ml in a glass bottle of amber color, sealed with a screwed aluminum cover and plastic measuring cap. One bottle together with the instruction for use is placed in a pack of cardboard.

Storage conditions:

In a dry, dark place at a temperature below 25 ° C.

Keep away from children.

Shelf life:3 years.

The drug should not be used at the expiration date indicated on the package.

Terms of leave from pharmacies:Without recipe

Registration number:P N014832 / 02-2003

Date of registration:21.07.2008

The owner of the registration certificate:Ipka Laboratories Ltd.Ipka Laboratories Ltd. India

Manufacturer: & nbsp

IPCA LABORATORIES, Ltd. India

Information update date: & nbsp08.12.2015

Illustrated instructions

Instructions

Solvin® (Solvin)