Bromhexine - instructions for use, dose, side effects, contraindications

The drug has mucolytic (secretolitic) and expectorant action. Mucolytic effect is associated with depolymerization and liquefaction of mucoprotein and mucopolysaccharide fibers. Bromhexine has a weak antitussive effect.

Pharmacokinetics:

Ingestion bromohexine almost completely (99% is absorbed within 30 minutes, bioavailability is 80% due to the effect of "first passage" through the liver. bromohexine binds to proteins, penetrates through blood-brain and placental barriers. In the liver bromohexine is subjected to demethylation and oxidation. The half-life is 15 hours due to slow reverse diffusion from the tissues. Excreted by the kidneys. In chronic renal failure, excretion of metabolites of bromhexine is impaired. With repeated use bromohexine can cumulate.

Indications:

Bronchopulmonary diseases accompanying the formation of sputum of increased viscosity (bronchial asthma, cystic fibrosis, tuberculosis, pneumonia, tracheobronchitis, obstructive bronchitis, boro jectectosis, pulmonary emphysema, pneumoconiosis), chest trauma, pre- and postoperative period.

Contraindications:

hypersensitivity to the components of the drug;
pregnancy (1 trimester);
lactation period;
children's age up to 3 years.

Dosing and Administration:

Bromhexine used inside regardless of food intake. Adults appoint 1-2 tablets 3-4 times a day; children from 3 to 5 years - 2 mg. from 6 to 14 years - 4 mg 3 times a day. The course of treatment is from 4 to 28 days.

During the treatment it is recommended to use a sufficient amount of liquid that supports secretion action bromohexine.

Side effects:

Rarely, with prolonged use of the drug, nausea, vomiting, dyspepsia, peptic ulcer, allergic reactions (skin rash, rhinitis, etc.) are possible, an increase in the level of transaminases in the blood serum.

In these cases, the drug should be discontinued.

Interaction:

Bromhexine it is possible to appoint simultaneously with other drugs used in the treatment of bronchopulmonary diseases.

Bromhexine Do not prescribe concomitantly with medicines containing codeine, as this makes it difficult to cough up thinned phlegm.

Bromhexine contributes to the penetration of antibiotics (erythromycin, cephalexin, oxytetracklin) into the lung tissue.

Bromhexine not compatible with alkaline solutions.

Form release / dosage:

Tablets to 0.008 g.

Packaging:

For 10, 20, 30, 40, 50 tablets in a contour cell package of polyvinyl chloride and aluminum foil foil lacquered.

By 10, 20, 30, 40, 50 or 100 tablets in polymer cans for medicines.

One bank or 1, 2, 3, 4, 5 or 10 contour cell packings together with instructions for use placed in a cardboard box (pack).

Storage conditions:

In a dry, sheltered from the world spot, at a temperature of no higher than 25 ° C.

Keep out of the reach of children place.

Shelf life:

3 years. This medicine can not be used after the date shown on the package.

Terms of leave from pharmacies:Without recipe

Registration number:P N002918 / 01

Date of registration:08.12.2008 / 10.11.2014

Expiration Date:Unlimited

The owner of the registration certificate:ATOLL, LLC ATOLL, LLC Russia

Manufacturer: & nbsp

OZONE, LLC Russia

Representation: & nbspPharmasynthesis, JSCPharmasynthesis, JSC

Information update date: & nbsp24.02.2017

Illustrated instructions

Instructions

Bromhexine (Bromhexine)