Bromhexine - instructions for use, dose, side effects, contraindications

Mucolytic (secretolitic), has an expectorant and weak antitussive effect. Reduces the viscosity of sputum (depolymerizes mucoprotein and mucopolysaccharide fibers, increases the serous component of the bronchial secretion); activates the ciliated epithelium., increases, volume and improves sputum discharge.Stimulates the production of endogenous surfactant, which ensures the stability of alveolar cells in the process of breathing. The effect is manifested after 2-5 days from the beginning of treatment.

Pharmacokinetics:

Ingestion bromohexine almost completely (99%) is absorbed in the gastrointestinal tract for 30 minutes. Bioavailability - about 80 % due to the effect of "first passage" through the liver. In the plasma bromohexine binds to proteins, penetrates through blood-brain and placental barriers. In the liver bromohexine is subjected to demethylation and oxidation. The half-life is 15 hours due to slow reverse diffusion from the tissues. Excreted by the kidneys. In chronic renal failure, the release of metabolites of bromhexine is disrupted. With repeated use bromohexine can cumulate.

Indications:

Diseases of the respiratory tract, accompanied by difficulty in moving away viscous sputum: tracheobronchitis, bronchitis of different etiology (including complicated by bronchiectasis), bronchial asthma, pulmonary tuberculosis, pneumonia, cystic fibrosis.

Sanitation of the bronchial tree in the preoperative period and during medical and diagnosticintrabronchial manipulation, prevention of congestion in the bronchi of thick viscous sputum after surgery.

Contraindications:

Hypersensitivity to the components of the drug, peptic ulcer of the stomach, pregnancy (1 trimester), lactation period, children's age (up to 3 years).

Carefully:

Renal and / or liver failure; bronchial diseases, accompanied by excessive accumulation of secretion, in the anamnesis - gastric bleeding.

Dosing and Administration:

Inside, regardless of food intake. Adults and children over 14 years of age - 8-16 mg 3-4 times a day, children from 6 to 14 years - 8 mg 3 times a day. If necessary, the adult dose can be increased to 16 mg 4 times a day. Children 3-6 years 4 mg 1/2 tablets 3 times a day. Therapeutic effect may appear on the 4-6th day of treatment.

The course of treatment is from 4 to 28 days.

Patients with renal insufficiency are prescribed smaller doses or increase the interval between administrations.

Side effects:

Allergic reactions, nausea, vomiting, exacerbation of peptic ulcer and duodenal ulcer, dizziness, headache, increased activity of "liver" transaminases (extremely rare).

Overdose:

Symptoms: nausea, vomiting, diarrhea.

Treatment: artificial vomiting, gastric lavage (in the first 1-2 hours after administration).

Interaction:

Bromhexine Do not prescribe concomitantly with drugs that suppress the cough center (incl. codeine), as this makes it difficult to escape the diluted sputum (bronchial secretion in the respiratory tract).

Bromhexine is incompatible with alkaline solutions.

Bromhexine contributes to the penetration of antibiotics (amoxicillin, erythromycin, cephalexin, oxytetracycline), sulfonamide drugs in the bronchial secret in the first 4-5 days of antimicrobial therapy.

Special instructions:

When treating, you must take a sufficient amount of fluid, which increases the expectorant effect of bromhexine.

In children, treatment should be combined with postural drainage or vibratory chest massage, which facilitates the secretion of bronchial secretions.

Form release / dosage:

Tablets of 8 mg.

Packaging:

For 10 tablets in a contour mesh package made of a polyvinyl chloride orange film and aluminum foil printed lacquered.

5 contour packs together with instructions for use in a pack of cardboard.

For 600 or 1000 contour packs of 10 tablets together with an equal number of instructions for use in cardboard boxes.

Storage conditions:

In a dry, protected from light place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:

3 years.

Do not use after expiry date.

Terms of leave from pharmacies:Without recipe

Registration number:P N001921 / 01

Date of registration:12.09.2008

Expiration Date:Unlimited

The owner of the registration certificate:FARMAKOR PRODUCTION, LTD. FARMAKOR PRODUCTION, LTD. Russia

Manufacturer: & nbsp

FARMAKOR PRODUCTION, LTD. Russia

Representation: & nbspFARMAKOR PRODUCTION LLC FARMAKOR PRODUCTION LLC Russia

Information update date: & nbsp25.02.2017

Illustrated instructions

Instructions

Bromhexine (Bromhexine)