Bromhexine-Akrihin - instructions for use, dose, side effects, contraindications

Composition:100 ml of syrup contain: active substance: bromhexine hydrochloride in terms of 100% substance - 0.08 g, auxiliary substances: propylene glycol 25.92 g, benzoic acid 0.1 g, sorbitol 36.7 g, levomentol 0.02 g, citric acid monohydrate 0.3 g, sodium saccharinate dihydrate (saccharin soluble) 0.15 g, vanillin 0.1 g, tropeolin dye 0 0.001 g, orange flavor 0.4 g, water purified to 100 ml

Description:

Yellow or light yellow transparent liquid with a characteristic odor. A slightly greenish shade is permissible.

Pharmacotherapeutic group:Expectorant mucolytic agent

ATX: & nbsp

R.05.C.B Mucolytics

R.05.C.B.02 Bromhexine

Pharmacodynamics:

Mucolytic (secretolitic), has an expectorant and weak antitussive effect. Reduces the viscosity of sputum (depolymerizes mukoproteinovye and mucopolysaccharide fibers, increases the serous component of the bronchial secretion); activates the ciliated epithelium; increases volume and improves sputum discharge. Stimulates the production of endogenous surfactant, which ensures the stability of alveolar cells in the process of breathing. The effect is manifested after 2-5 days from the beginning of treatment.

Pharmacokinetics:

Ingestion bromohexine almost completely (99%) is absorbed within 30 minutes. About 80% of bromhexine undergoes intensive metabolism, due to the effect of the first "passage" through the liver. In the plasma bromohexine binds to proteins, penetrates through blood-brain and placental barriers. In the liver bromohexine is demethylated and oxidized to form an active metabolite - ambroxol. The half-life is 15 hours due to slow reverse diffusion from the tissues. It is excreted by the kidneys. In chronic renal failure, excretion of metabolites of bromhexine is impaired. With repeated use bromohexine can cumulate.

Indications:

Diseases of the respiratory tract, accompanied by difficulty in moving away viscous sputum: tracheobronchitis, bronchitis of different etiology (including complicated by bronchiectasis), bronchial asthma, pulmonary tuberculosis, pneumonia, cystic fibrosis.

Sanitation of the bronchial tree in the preoperative period and during medical and diagnostic intrabronchial manipulation, prevention, accumulation in the bronchi of thick viscous sputum after the operation.

Contraindications:

Hypersensitivity, peptic ulcer of the stomach, pregnancy (I trimester); lactation period.

Carefully:

Renal and / or liver failure; bronchial diseases, accompanied by excessive accumulation of secretion, in the anamnesis - gastric bleeding.

Dosing and Administration:

Inside, regardless of food intake.

Adults and children over 14 years: 8-16 mg (10-20 ml) 3-4 times a day.

Children under 2 years - 2 mg (2.5 ml) 3 times a day, from 2 to 6 years - 2-4 mg (2.5-5 ml) 3 times a day, from 6 to 14 years - 4 -8 mg (5-10 ml) 3 times a day.

The course of treatment is from 4 to 28 days.

Side effects:

Allergic reactions, dyspepsia, incl. nausea, vomiting; exacerbation of peptic ulcer of stomach and duodenum, dizziness, headache, increased activity of "liver" transaminases.

Overdose:

Symptoms: dyspeptic disorders, incl. nausea, vomiting, diarrhea.

Treatment: artificial vomiting, gastric lavage (in the first 1-2 hours after administration).

Interaction:

Do not prescribe concomitantly with drugs that suppress the cough center (incl. codeine), as this makes it difficult to withdraw-diluted sputum (the accumulation of bronchial secretions in the respiratory tract).

Incompatible with alkaline solutions.

Bromhexine contributes to the penetration of antibiotics (amoxicillin, erythromycin, cephalexin, oxytetracycline), sulfonamide drugs in the bronchial secret in the first 4-5 days of antimicrobial therapy.

Special instructions:

When treating, you must take a sufficient amount of fluid, which increases the expectorant effect of bromhexine.

In children, treatment should be combined with postural drainage or vibratory chest massage, which facilitates the secretion of bronchial secretions.

Effect on the ability to drive transp. cf. and fur:During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities,requiring increased concentration of attention and speed of psychomotor reactions.

Form release / dosage:

Syrup 4 mg / 5 ml.

Packaging:To 100 ml in a bottle of dark glass, sealed with a cap screwed from polyethylene with the control of the first opening. Each vial with a measuring spoon or measuring cup and instruction for use is placed in a pack of cardboard.

Storage conditions:

At a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

4 years. Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:P N002664 / 01

Date of registration:17.06.2008 / 31.03.2016

Expiration Date:Unlimited

The owner of the registration certificate:AKRIKHIN HFK, JSC AKRIKHIN HFK, JSC Russia

Manufacturer: & nbsp

AKRIKHIN HFK, JSC Russia

Representation: & nbspAKRIKHIN OJSC AKRIKHIN OJSC Russia

Information update date: & nbsp25.02.2017

Illustrated instructions

Instructions

Bromhexine-Abrichin (Bromhexine-Akrichin)