Bromhexine - instructions for use, dose, side effects, contraindications

1 tablet contains, as active ingredient: 0.008 g of bromhexine hydrochloride. Auxiliary substances: sugar, milk sugar, potato starch, calcium stearic acid.

Description:

Ploskotsilindricheskie tablets of white color with a bevel.

Pharmacotherapeutic group:Mucolytic agent

ATX: & nbsp

R.05.C.B Mucolytics

R.05.C.B.02 Bromhexine

Pharmacodynamics:

The drug has mucolytic (secretolitic) and expectorant action. Mucolytic effect is associated with depolymerization and liquefaction of mucoprotein and mucopolysaccharide fibers. Bromhexine has a weak antitussive effect.

Pharmacokinetics:

Ingestion bromohexine almost completely (99%) is absorbed within 30 minutes. Bioavailability is 80% due to the effect of "first passage" through the liver. In the plasma bromohexine binds to proteins, penetrates through blood-brain and placental barriers. In the liver bromohexine is subjected to demethylation and oxidation. The half-life is 15 hours due to slow reverse diffusion from the tissues. Excreted by the kidneys. In chronic renal failure, the release of metabolites of bromhexine is disrupted. With multiple use bromohexine can cumulate.

Indications:

Bronchopulmonary diseases accompanied by the formation of sputum of increased viscosity (bronchial asthma, cystic fibrosis, tuberculosis, pneumonia, tracheobronchitis, obstructive bronchitis, bronchiectasis, pulmonary emphysema, pneumoconiosis), chest trauma, pre- and postoperative period.

Contraindications:

hypersensitivity to the components of the drug;
pregnancy (1 trimester);
lactation period;
children under 3 years old

Dosing and Administration:

Bromhexine take inside regardless of food intake.Adults appoint 1-2 tablets 3-4 times a day; children from 3 to 5 years - 2 mg, from 6 to 14 years - 4 mg 3 times a day. The course of treatment is from 4 to 28 days.

During the treatment it is recommended to use a sufficient amount of liquid that supports the secretolitic action of bromhexine.

Side effects:

Rarely, with prolonged use of the drug, nausea, vomiting, dyspepsia, peptic ulcer, allergic reactions (skin rash, rhinitis, etc.) are possible, an increase in the level of transaminases in the blood serum. In these cases, the drug should be discontinued.

Interaction:

Bromhexine can be administered simultaneously with other drugs used in the treatment of bronchopulmonary diseases.

Bromhexine Do not prescribe concomitantly with medicines containing codeine, as this makes it difficult to cough up thinned phlegm.

Bromhexine promotes the penetration of an antibiotic (erythromycin, cephalexin, oxytetracycline) into the lung tissue.

Bromhexine not compatible with alkaline solutions.

Form release / dosage:Tablets to 0.008 g.

Packaging:10 tablets in a planar cell package; 5 contour packs with instructions for use in the pack.50 tablets in a can of polyethylene or polystyrene. Bank with instructions for use in the pack.

Storage conditions:

In a dry place protected from light.

Keep out of the reach of children.

Shelf life:

3 years. This medicine can not be used after the date shown on the package.

Terms of leave from pharmacies:Without recipe

Registration number:P N001708 / 01-2003

Date of registration:08.12.2008

Expiration Date:Unlimited

The owner of the registration certificate:BIOSINTEZ, PAO BIOSINTEZ, PAO Russia

Manufacturer: & nbsp

BIOSINTEZ, PAO Russia

Information update date: & nbsp25.02.2017

Illustrated instructions

Instructions

Bromhexine (Bromhexine)