Naphthyzine - instructions for use, dose, side effects, contraindications

Alpha-adrenostimulating agent, has a rapid, pronounced and prolonged vasoconstrictor action against the vessels of the mucous membranes (reduces swelling, flushing, exudation). Relieves nasal breathing in rhinitis. After 5-7 days there is tolerance.

Pharmacokinetics:

With topical application, systemic absorption is low.

Indications:

Acute rhinitis (including acute respiratory diseases and allergic rhinitis), sinusitis, eustachiitis, laryngitis, laryngeal edema of allergic genesis, laryngeal edema on the background of irradiation, hyperemia of the mucosa after operations on the upper respiratory tract.To stop nasal bleeding.

Contraindications:

- Hypersensitivity to naphazoline or any of the excipients,

- arterial hypertension,

- severe atherosclerosis,

- thyrotoxicosis,

- severe eye diseases, including angle-closure glaucoma,

- chronic rhinitis,

- Atrophic rhinitis,

- diabetes,

- tachycardia,

- simultaneous administration of monoamine oxidase inhibitors and within 14 days after the end of their use,

- for a solution of 0.05% - children under 2 years of age,

- for a solution of 0.1% - children under the age of 15 years.

Carefully:

Ischemic heart disease (angina pectoris), prostatic hyperplasia, pheochromocytoma, during pregnancy and breastfeeding.

Pregnancy and lactation:

Use during pregnancy and during breastfeeding is possible only if the expected benefit to the mother exceeds the potential risk to the fetus or child.

Dosing and Administration:

Intranasally (in each nasal passage), adults and children over 15 years are prescribed 1-3 drops of 0.05% - 0.1% solution 3-4 times a day.

In children older than 2 years, 0.05% solution is used (or 0.025% solution, diluting 0,05% solution with distilled water): from 2 to 6 years - 1-2 drops, from 6 to 15 years - 2 drops of 1- 3 times a day.

For diagnostic purposes - after cleaning the nose in each nasal passage, drip 3-4 drops or insert a swab soaked in a 0.05% solution and leave for 1-2 minutes; When swelling of the vocal cords, administer small doses of a laryngeal syringe; with bleeding - insert a tampon moistened with 0.05% solution.

Apply for a short time, but not more than 1 week, not more than 3 days for children. If nasal breathing is facilitated, then the use of Naphthyzine can be completed sooner. Repeated use of the drug is possible in a few days.

Before the administration of the drug should be thoroughly cleaned nasal passages.

Side effects:

Burning or dryness of the nasal mucosa; a feeling of "stuffiness" of the nose (reactive hyperemia after stopping the effect of the drug, swelling of the nasal mucosa), tachycardia, increased blood pressure, headache, irritability, nausea, allergic reactions. Prolonged and frequent use of naphazoline may lead to chronic disruption of nasal passages and atrophy of the nasal mucosa (medicamentous rhinitis).

Overdose:

When an overdose of the drug as a result of systemic effects on the bodymay develop such phenomena as nervousness, excessive sweating, headache, tremor, tachycardia, a feeling of palpitations, increased blood pressure. Also possible signs of an overdose include nausea, cyanosis, respiratory and mental disorders.

In the case of central nervous system depression, bradycardia, weakness, drowsiness, decreased body temperature, increased sweating, collapse, it is extremely rare for coma to develop.

Treatment: gastric lavage, reception of activated charcoal (with accidental ingestion of the drug inside); symptomatic.

Interaction:

Do not use simultaneously with monoamine oxidase inhibitors or within 14 days after the end of their use. Slows the absorption of local anesthetic drugs (lengthens their action in the conduct of surface anesthesia).

Special instructions:

May have a resorptive effect.

With prolonged use, the severity of the vasoconstrictor effect gradually decreases (the phenomenon of tachyphylaxis), in connection with which it is recommended after 5-7 days of use to take a break for several days.In view of the possible development of side effects from the cardiovascular and nervous systems, do not exceed the dose of Naphthysin recommended for use. Avoid contact with the eyes. To avoid the spread of infection, it is necessary to apply the drug individually.

Effect on the ability to drive transp. cf. and fur:

After a prolonged use or intake of funds from the cold, containing naphazoline, in dosages exceeding the recommended, it is impossible to exclude the general effect on the cardiovascular system and the central nervous system. In these cases, the ability to drive vehicles and moving machinery can be reduced.

Form release / dosage:

Nasal drops 0.05 % and 0.1%.

Packaging:

10 ml or 15 ml in bottles of polymer droppers with a screw cap, a stopper and a screw cap with a control ring of the first opening or in bottles of polymer droppers with a screw mouth, a nozzle-dispenser and a screw cap with a control ring of the first opening.

1 bottle-dropper polymer together with the instruction for use is placed in a pack of cardboard.

Storage conditions:

At a temperature of no higher than 25 ° C, in the original packaging.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LS-000273

Date of registration:31.03.2010 / 02.02.2018

Expiration Date:Unlimited

The owner of the registration certificate:Pharmaceutical firm LEKKO, ZAO Pharmaceutical firm LEKKO, ZAO Russia

Manufacturer: & nbsp

Pharmaceutical firm LEKKO, ZAO Russia

Information update date: & nbsp17.06.2018

Illustrated instructions

Instructions

Naphthysine (Naphthyzin)