Retinol acetate (vitamin A) - instructions for use, dose, side effects, contraindications

Active substance:
Retinol acetate (vitamin A) in terms of 100% vitamin A *	- 11.35 mg (33,000 ME)
Excipient:
Sunflower oil	- up to 150 mg
The composition of the shell in terms of absolutely dry matter:
Gelatin	- 52.75 mg
Glycerol	- 16.80 mg
Methylparahydroxybenzoate	- 0.45 mg
* Note. 1 g of Vitamin A-acetate substance mafuselage stabilized BHT-oil solution contains:
Retinol acetate	- 1.5 million ME
Butylhydroxytoluene (BHT)	- 15 mg
Peanut butter	- up to 1 g

Description:Mgelatin capsules of a spherical shape from yellow to light brown, filled with oily liquid from light yellow to dark yellow color, without a rancid smell.

Pharmacotherapeutic group:vitamin

ATX: & nbsp

A.11.C.A Vitamin A

A.11.C.A.01 Retinol

Pharmacodynamics:

Vitamin A is a fat-soluble vitamin. It is important in the formation of visual purple (it is necessary to adapt the vision when light is reduced), cell proliferation and trophic epithelial tissues.

Pharmacokinetics:

Quickly absorbed from the gastrointestinal tract (mainly from the 12-finger and jejunum), the presence of bile acids, pancreatic lipase, proteins and fats is required. The connection with plasma proteins (lipoproteins) in the norm is not less than 5%; with excessive intake of vitamin A with food and overflow to the liver depot, its association with plasma lipoproteins can reach up to 65%.The amount of bound vitamin A with lipoproteins can increase with hyperlipoproteinemia. When released from the liver depot, the vitamin forms a complex with the retinol-binding protein, in the form of which circulates in the blood. In small amounts penetrates into breast milk and through the placenta. It is deposited in the liver (approximately in the amount of the biennial needs of the adult organism), in small amounts - in the kidneys, lungs. To mobilize vitamin A from the depot zinc-containing substances are required. Metabolised in the liver. It is excreted by the intestine (non-sucking part) and kidneys.

Indications:Treatment of Vitamin A deficiency

Contraindications:

- Hypersensitivity to any component of the drug;

- hypervitaminosis A;

- violation of lipid absorption;

- chronic malabsorption;

- concomitant therapy, preventing the absorption of vitamin A;

- Pregnancy;

- the use of this medication during breastfeeding is not recommended (see the section "Use during pregnancy and during lactation").

- is contraindicated to persons with intolerance to peanuts;

- childhood.

Carefully:

Nephritis, heart failure 2-3 degrees, alcoholism, liver cirrhosis, viral hepatitis, renal failure, elderly.

Pregnancy and lactation:

Contraindicated use during pregnancy and during breastfeeding.

Dosing and Administration:The drug is taken orally, 1 capsule 1 time per day, 10-15 minutes after meals. The duration of the drug is 1 month. Repeated courses - on the advice of a doctor.

Side effects:

Undesirable reactions may be signs of an overdose and require withdrawal of the drug.

Allergic reactions.

Overdose:

Clinical signs of acute overdose of vitamin A (doses in excess of 150,000 ME): gastrointestinal disturbances, headache, increased intracranial pressure (in children it is manifested by bulging of the fontanelle), edema of the optic nerve disk, mental disorders, irritability, convulsions, in the later stages - generalized desquamation.

Clinical signs of a chronic overdose of vitamin A: intracranial hypertension, cortical hyperostosis of tubular bones and early closure of epiphyseal growth zones. The diagnosis is usually based on the detection of sensitive or painful subcutaneous edema of the distal parts of the limbs.Radiography reveals a thickening of the periosteum of the elbow, fibula, collarbone and ribs.

Treatment: symptomatic.

Interaction:

Contraindicated combinations

Tetracyclines

When taken in a dose of 10 000 ME and more - the risk of developing intracranial hypertension.

Retinoids

Increased risk of hypervitaminosis A.

Special instructions:

Do not take at the same time other multivitamin complexes containing vitamin A, in order to avoid an overdose.

Features of the drug during the first admission or when it is canceled

There is no information.

Effect on the ability to drive transp. cf. and fur:

The use of the drug does not affect the performance of potentially hazardous activities requiring special attention and quick reactions (dispatcher work, vehicle management, work with moving mechanisms).

Form release / dosage:

Capsules, 33 000 ME.

Packaging:

10 capsules per contour cell packaging made of polyvinylchloride film and aluminum foil printed lacquered.

By 2, 3, 4 contour mesh packs together with instructions for use are placed in a pack of cardboard.

For hospitals: 50, 100, 200 contour mesh packages, together with an equal number of instructions for use, are placed in boxes of corrugated cardboard.

By 20, 30, 40 capsules in cans of polymeric with polymer caps.

Each bank along with the instruction for use is placed in a pack of cardboard.

For hospitals: 42 or 54 banks along with an equal number of instructions for use are placed in boxes of corrugated cardboard.

Storage conditions:

In dry, dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years.

Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LP-003705

Date of registration:24.06.2016

Expiration Date:24.06.2021

The owner of the registration certificate:TULA PHARMACEUTICAL FACTORY, LTD. TULA PHARMACEUTICAL FACTORY, LTD. Russia

Manufacturer: & nbsp

TULA PHARMACEUTICAL FACTORY, LTD. Russia

Representation: & nbspTULA PHARMACEUTICAL FACTORY, LTD.TULA PHARMACEUTICAL FACTORY, LTD.

Information update date: & nbsp16.08.2016

Illustrated instructions

Instructions

Retinol acetate (vitamin A) (Retinol acetate (vitamin A))