Retinol acetate - instructions for use, dose, side effects, contraindications

Retinol acetate content in 1 ml of oily solution 3,44% - 100000 ME, at 1 drop - 5000 ME and oil solution 8,6% at 1 ml - 250000 ME, at 1 drop - 12500 ME.

Description:

Transparent oily liquid from light yellow to dark yellow without rancid smell.

Pharmacotherapeutic group:Vitamin.

ATX: & nbsp

A.11.C.A Vitamin A

A.11.C.A.01 Retinol

Pharmacodynamics:Vitamin A has a restorative effect, normalizes tissue metabolism; participates in oxidation-reduction processes (due to a large number of unsaturated bonds), in the synthesis of mucopolysaccharides, proteins, lipids, in mineral metabolism, and cholesterol formation processes. Strengthens the production of lipase and trypsin, enhances myelopoiesis, cell division processes. Increases the body's resistance to infection. Strengthens the division of skin epithelial cells, inhibits the keratinization process, enhances the synthesis of glycosaminoglycans. Participates in the processes of photoreception (improves visual adaptation to darkness).

Indications:

Hypovitaminosis, avitaminosis A.

In complex therapy of conditions, accompanied by an increased need for vitamin A:

- Infectious-inflammatory (including chronic) and "catarrhal" diseases;

- lesions and skin diseases (frostbite I degree, burns 1 degree, ichthyosis, hyperkeratosis, seborrheic dermatitis, psoriasis, neurodermatitis, some forms of eczema).

- eye diseases (retinitis pigmentosa, hemostalopia, xerophthalmia, keratomalacia, eczematous lesions of the eyelids).

- gastrointestinal diseases associated with impaired absorption of retinol (gastroectomy, diarrhea, steatorrhea, celiac disease, Crohn's disease, malabsorption syndrome).

Contraindications:Hypersensitivity to the components of the drug, hypervitaminosis A, pregnancy, cholelithiasis, chronic pancreatitis, acute inflammatory skin diseases, children under seven.

Carefully:Jade, heart failure II-III alcoholism, liver cirrhosis, viral hepatitis, renal failure, elderly age.

Dosing and Administration:The drug should be used under medical supervision. The drug is taken orally (through 10-15 minutes after eating) early in the morning or late in the evening.
The highest single therapeutic dose for adults - 50000 ME, daily - 100000 ME; for children, respectively - 5000 ME and 20000 ME.
C therapeutic purpose for avitaminosis of mild and moderate severity is prescribed by adults to 33000 ME per day (retinol acetate solution in oil 3,44% - 6 drops), children older 7 years on 5000 ME per day (1 drop of retinol acetate solution in oil 3,44%).
When diseases of the eyes are prescribed for adults - 50000-100000 ME per day (a solution of retinol acetate in oil 3,44% - 10-20 drops) and simultaneously 0.02 g of riboflavin.
When skin diseases are prescribed for adults per day by 50000-100000 ME retinol acetate and 5000 - 10000 - 20000 ME children.
External appoint for frostbite, burns. Affected area after cleaning is lubricated with a solution and covered with a gauze dressing (before 5-6 once a day, as scarring and epithelization, the lubrication frequency is reduced to 1 once a day), simultaneously retinol prescribe inside or intramuscularly.

Side effects:

Allergic reactions.

Prolonged daily intake of vitamin A can cause intoxication, hypervitaminosis A. Symptoms of hypervitaminosis A in adults - headache, drowsiness, lethargy, hyperemia of the face, nausea, vomiting, tenderness in the bones of the lower extremities, gait disturbance. Children can be observed: fever, drowsiness, sweating, vomiting, skin rashes.

Overdose:

Symptoms of acute overdose (develop through 6 hours after taking): hypervitaminosis A: in adults - drowsiness, lethargy, double vision, dizziness, severe headache, nausea, indomitable vomiting, diarrhea, irritability, bleeding gums, dryness and ulceration of the oral mucosa, exfoliation of the lips, skin ( especially palms), confusion, increased intracranial pressure (in infants - hydrocephalus, protrusion of the fontanel).

Symptoms of chronic intoxication: loss of appetite, bone pain, cracks and dry skin, dryness of the oral mucosa, lips, gastralgia, vomiting, hyperthermia, asthenia, excessive fatigue, headache, photosensitivity, pollakiuria, nocturia, polyuria, irritability, hair loss, yellow-orange stains on the soles, palms, in the nasolabial triangle, hepatotoxic phenomena, intraocular hypertension, oligomenorrhoea, portal hypertension, hemolytic anemia, changes in radiographs of bones, convulsions.

Treatment: discontinuation of the drug; symptomatic therapy.

Interaction:During prolonged therapy with tetracyclines, vitamin A is not recommended (the risk of developing intracranial hypertension increases).
Salicylates and glucocorticosteroids reduce the risk of side effects. Kolestyramine, colestipol, mineral oils, neomycin reduce absorption of vitamin A (a dose increase may be required).
Oral contraceptives increase the concentration of vitamin A in the plasma.
Isotretinoin increases the risk of toxic effects.

Special instructions:

Do not take at the same time other multivitamin complexes containing vitamin A, in order to avoid an overdose.

Form release / dosage:

Solution for oral and external use oily 3,44 % and 8,60 %.

Packaging:

By 10, 15 ml in bottles of droppers of orange glass, ukuporennyh stoppers, droppers and lids.

By 10, 15, 50, 100 ml in bottles of orange or brown glass, sealed with polyethylene plugs and screwed caps. Each vial or dropper along with the instruction for use is placed in a pack of cardboard for consumer containers.

Storage conditions:In the dark place, with temperature not higher 10 ⁰C.
Keep out of the reach of children.

Shelf life:

3 of the year. Use at the latest on the date indicated on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LS-000913

Date of registration:10.06.2010

The owner of the registration certificate:MARBIOFARM, OJSC MARBIOFARM, OJSC Russia

Manufacturer: & nbsp

MARBIOFARM, OJSC Russia

Information update date: & nbsp05.08.2015

Illustrated instructions

Instructions

Retinol acetate (Retinol acetate)