Active substanceRetinolRetinol Similar drugsTo uncover Widestim® ointment externally RETYNOIDS FNPP, CJSC Russia Retinol capsules ALTAYVITAMINS, CJSC Russia Retinol pills inwards VEROPHARM SA Russia Retinol acetate solution inwards externally TECHNOLOG, PAO Ukraine Retinol acetate drops inwards externally PHARMACEUTICAL FACTORY of St. Petersburg, JSC Russia Retinol acetate solution inwards externally MARBIOFARM, OJSC Russia Retinol acetate capsules inwards externally MARBIOFARM, OJSC Russia Retinol acetate solution inwards MUROMSKY INSTRUMENT-MAKING PLANT, FSUE Russia Retinol acetate (Vitamin A) capsules inwards LYUMI, LLC Russia Retinol acetate (vitamin A) capsules inwards LYUMI, LLC Russia Retinol acetate (vitamin A) capsules inwards TULA PHARMACEUTICAL FACTORY, LTD. Russia Retinol acetate solution in oil solution inwards PHARMACEUTICAL FACTORY of St. Petersburg, JSC Russia Retinola palmitate pills inwards MARBIOFARM, OJSC Russia Retinola palmitate solution inwards RETYNOIDS FNPP, CJSC Russia Dosage form: & nbspCapsules. Composition:Retinol acetate (vitamin A) * - 33000 ME;Soybean oil - up to 150 mg; The composition of the shell in terms of absolutely dry matter:Gelatin - 52,75 mg;Glycerol 16,80 mg;Methylparahydroxybenzoate 0.45 mg;* Composition per 1 g:Vitamin A acetate - 520 mg (1.5 million ME);d1-α-tocopherol-15 mg;Peanut butter - 465 mg; Description:Capsules of spherical form are yellow, filled with oily liquid from light yellow to dark yellow color, without a rancid smell. Pharmacotherapeutic group:Vitamin. ATX: & nbspA.11.C.A Vitamin AA.11.C.A.01 Retinol Pharmacodynamics:Vitamin A has a restorative effect, normalizes tissue metabolism; participates in oxidation-reduction processes (due to a large number of unsaturated bonds), in the synthesis of mucopolysaccharides, proteins, lipids, in mineral metabolism, and the processes of cholesterol formation. Strengthens the production of lipase and trypsin, enhances myelopoiesis, cell division processes. Has a positive effect on the function of lacrimal, sebaceous and sweat glands; increases resistance to diseases of the mucous membranes of the respiratory tract and intestines; increases the body's resistance to infection. It enhances the division of skin epithelial cells, rejuvenates the cellular population, inhibits keratinization processes, enhances the synthesis of glycosaminoglycans, activates the interaction of immunocompetent cells with each other and epidermal cells. Stimulates skin regeneration.Participates in the processes of photoreception (contributes to the adaptation of man to the dark). Local action is due to the presence on the cell surface of the epithelium of specific retinol-binding receptors. Pharmacokinetics:Quickly absorbed from the gastrointestinal tract (mainly from the 12-finger and jejunum), the presence of bile acids, pancreatic lipase, proteins and fats is required. The connection with plasma proteins (lipoproteins) is normal - less than 5%; with excessive intake of vitamin A with food and overflow to the liver depot, its association with plasma lipoproteins can reach up to 65%. The amount of bound vitamin A with lipoproteins can increase with hyperlipoproteinemia. When released from the liver depot, the vitamin forms a complex with the retinol-binding protein, in the form of which circulates in the blood. In small amounts penetrates into breast milk and through the placenta. It is deposited in the liver (approximately in the amount of the biennial needs of the adult organism), in small amounts - in the kidneys, lungs. To mobilize vitamin A from the depot zinc-containing substances are required. Metabolised in the liver. It is excreted by the intestine (non-sucking part) and kidneys. Indications:Hypovitaminosis, avitaminosis A.In complex therapy:- infectious and inflammatory diseases (measles, dysentery, influenza, tracheitis, bronchitis, etc.)- lesions and skin diseases (frostbite, burns, wounds, erosion, ulcers, cracks, ichthyosis, hyperkeratosis, seborrheic dermatitis, psoriasis, neurodermatitis, some forms of eczema, skin tuberculosis),- eye diseases (retinitis pigmentosa, hemostalopia, xerophthalmia, keratomalacia, eczematous lesions of the eyelids).- gastrointestinal diseases (erosive gastroduodenitis, peptic ulcer of the stomach and duodenum). Contraindications:Increased sensitivity to the drug, hypervitaminosis A, gallstone disease, chronic pancreatitis, acute inflammatory skin diseases, pregnancy and lactation, infancy. Carefully:Nephritis, heart failure II-III, alcoholism, liver cirrhosis, viral hepatitis, renal failure, elderly age. Dosing and Administration:The drug is administered orally early in the morning or late in the evening (10-15 minutes after eating).Therapeutic doses for adults with avitaminosis of mild and moderate severity are up to 33000 IU / day.With eye diseases prescribed for adults 50000-100000 IU / day and 0.02 g of riboflavin simultaneously.For diseases of the skin, adults are prescribed 50000-100000 IU / day.The daily intake for adults should not exceed 100,000 ME. Side effects:Long-term daily intake of vitamin A (200,000 ME - adult) can cause intoxication, hypervitaminosis A. Symptoms of hypervitaminosis A in adults - headache, drowsiness, weakness, facial flushing, nausea, vomiting, pain in the bones of the lower limbs, impaired gait. Overdose:Symptoms of acute overdose (occurring within 6 hours after administration): hypervitaminosis A: adults - drowsiness, weakness, double vision, dizziness, severe headache, nausea, severe vomiting, diarrhea, irritability, osteoporosis, bleeding gums, dryness and ulceration of the mucous oral cavity, lips peeling, skin (especially the palms), confusion, increased intracranial pressure.Symptoms of chronic intoxication: loss of appetite, pain in the bones, crack and dry skin, dryness of the oral mucosa, gastralgia, vomiting, pyrexia, asthenia, excessive fatigue, discomfort, headache,photosensitivity, pollakiuria, nocturia, polyuria, irritability, hair loss, yellow-orange spots on the soles, palms, in the nasolabial triangle, hepatotoxic phenomena, intraocular hypertension, oligomenorrhoea, portal hypertension, hemolytic anemia, changes in bone radiographs, convulsions.Treatment: withdrawal of the drug, symptomatic therapy. Interaction:Weaken the effect of calcium preparations, increases the risk of hypercalcemia. Kolestyramine, colestipol, mineral oils, neomycin reduce absorption of vitamin A (you may need to increase its dose).Oral contraceptives increase the concentration of vitamin A in the plasma. Isotretinoin increases the risk of toxic effects.Simultaneous use of tetracycline and vitamin A in high doses (50 thousand units or more) increases the risk of developing intracranial hypertension. Special instructions:Do not take at the same time other multivitamin complexes containing vitamin A, in order to avoid an overdose. Form release / dosage:Capsules 33000 ME. Packaging:10 capsules per contour cell packaging of polyvinylchloride film and paper with a polymer coating or foil of aluminum printed lacquered.By 2, 3, 4 contour mesh packages along with the instruction for use are placed in a pack of chromium-ersatz cardboard or cardboard box.1, 2, 3, 5, 10, 20, 50 contour mesh packages, together with an equal number of instructions for use, are placed in a polyethylene hermetically sealed bag of lightproof polyethylene film, or of a material combined on paper and cardboard basis, or from a combined " Buflen ", or from a two-layer combined material.50, 100, 200, 400, 600 contour mesh packages together with an equal number of instructions for use are placed in a sealed polyethylene hermetically sealed bag of light-tight polyethylene film.It is allowed to apply instructions for use on the package.Polyethylene packaging is placed in a cardboard box.For hospitals 50, 100, 200, 400, 600 contour cells, together with the instruction for use, are placed in a cardboard box. Storage conditions:List B.In dry, dark place at a temperature of no higher than 25 0C Keep out of reach of children. Shelf life:2 years.Do not use after expiry date. Terms of leave from pharmacies:Without recipe Registration number:P N001778 / 01 Date of registration:04.12.2008 The owner of the registration certificate:LYUMI, LLC LYUMI, LLC Russia Manufacturer: & nbspLYUMI, LLC Russia Representation: & nbspLYUMI, LLCLYUMI, LLC Information update date: & nbsp05.08.2015 Illustrated instructions × Illustrated instructions Instructions