Active substanceRetinolRetinol Similar drugsTo uncover Widestim® ointment externally RETYNOIDS FNPP, CJSC Russia Retinol capsules ALTAYVITAMINS, CJSC Russia Retinol pills inwards VEROPHARM SA Russia Retinol acetate solution inwards externally TECHNOLOG, PAO Ukraine Retinol acetate drops inwards externally PHARMACEUTICAL FACTORY of St. Petersburg, JSC Russia Retinol acetate solution inwards externally MARBIOFARM, OJSC Russia Retinol acetate capsules inwards externally MARBIOFARM, OJSC Russia Retinol acetate solution inwards MUROMSKY INSTRUMENT-MAKING PLANT, FSUE Russia Retinol acetate (Vitamin A) capsules inwards LYUMI, LLC Russia Retinol acetate (vitamin A) capsules inwards LYUMI, LLC Russia Retinol acetate (vitamin A) capsules inwards TULA PHARMACEUTICAL FACTORY, LTD. Russia Retinol acetate solution in oil solution inwards PHARMACEUTICAL FACTORY of St. Petersburg, JSC Russia Retinola palmitate pills inwards MARBIOFARM, OJSC Russia Retinola palmitate solution inwards RETYNOIDS FNPP, CJSC Russia Dosage form: & nbspCapsules. Composition:One capsule contains:active components:retinol acetate acetate solution for oral and external use oil 8.60% - 0.132 ml (33000 IU)Excipients: refined deodorized sunflower oilcomposition of the shell: gelatin, glycerol (glycerol), methyl parahydroxybenzoate (nipagin), quinoline yellow dye (quinoline yellow dye E-104). Description:Capsules of a spherical form of yellow color without drips and mechanical impurities, are filled with oily liquid from light yellow to dark yellow color without a rancid odor. Pharmacotherapeutic group:Vitamin. ATX: & nbspA.11.C.A Vitamin AA.11.C.A.01 Retinol Pharmacodynamics:Vitamin A has a restorative effect, normalizes tissue metabolism; participates in oxidation-reduction processes (due to a large number of unsaturated bonds), in the synthesis of mucopolysaccharides, proteins, lipids, in mineral metabolism, and cholesterol formation processes. Strengthens the production of lipase and trypsin, enhances myelopoiesis. processes of cell division. Has a positive effect on the function of lacrimal, sebaceous and sweat glands; increases resistance to diseases of the mucous membranes of the respiratory tract and intestines; increases the body's resistance to infection. It enhances the division of skin epithelial cells, rejuvenates the cellular population, inhibits keratinization processes,enhances the synthesis of glycosaminoglycans, activates the interaction of immunocompetent cells with each other and epidermal cells. Stimulates skin regeneration. Participates in the processes of photoreception (contributes to the adaptation of man to the dark). Local action is due to the presence on the cell surface of the epithelium of specific retinol-binding receptors. Indications:Hypovitaminosis, avitaminosis A. In complex therapy:Infectious-inflammatory diseases (dysentery, influenza, tracheitis, bronchitis, etc.);and skin diseases (skin cracks, ichthyosis, hyperkeratosis, seborrheic dermatitis, psoriasis, neurodermatitis, some forms of eczema, skin tuberculosis);- eye diseases (pigment retinitis, hemostalopia, xerophthalmia, keratomalacia, eczematous lesions of the eyelids);- Gastrointestinal diseases (erosive gastroduodenitis, peptic ulcer of stomach and duodenum);- Cirrhosis of the liver. Contraindications:Hypersensitivity to the components of the drug, hypervitaminosis A, pregnancy, cholelithiasis, chronic pancreatitis, acute inflammatory skin diseases, children's age. Carefully:Nephritis, heart failure II-III, alcoholism, liver cirrhosis, viral hepatitis, renal failure, elderly age. Dosing and Administration:The drug should be used under medical supervision. The drug is taken orally after meals early in the morning or late in the evening.Therapeutic doses for adults with avitaminosis of mild and moderate severity are up to 33000 IU / day.In diseases of the eyes, adults are prescribed 100,000 IU of retinol acetate per day and simultaneously 0.02 g of riboflavin.When skin diseases are prescribed to adults per day for 100,000 ME retinol acetate.The daily intake for adults should not exceed 100,000 ME. Side effects:Allergic reaction to the components of the drug, hypervitaminosis A. Overdose:Symptoms of acute overdose (develop 6 hours after injection): hypervitaminosis A: in adults - drowsiness, lethargy, double vision, dizziness, severe headache, nausea, indomitable vomiting, diarrhea, irritability, osteoporosis, bleeding from the gums, dryness and ulceration mucous membrane of the oral cavity, peeling of the lips, skin (especially the palms), confusion, increased intracranial pressure (in infants - hydrocephalus, protrusion of the fontanel).Symptoms of chronic intoxication: loss of appetite, bone pain, cracks and dry skin, lips, dryness of the oral mucosa, gastralgia, vomiting, hyperthermia, asthenia, fatigue, headache, photosensitivity, pollakiuria, nocturia, polyuria, increased irritability, prolapse hair, yellow-orange spots on the soles, palms, in the area of the nasolabial triangle, hepatotoxic phenomena, intraocular hypertension, oligomenorrhoea, portal hypertension, hemolytic anemia, bone changes to X-rays grams, convulsions; fetotoxic phenomena: malformations of the urinary system, growth retardation, early closure of epiphyseal growth zones.Treatment: withdrawal of the drug, symptomatic therapy. Interaction:During prolonged therapy with tetracyclines, vitamin A is not recommended (the risk of developing intracranial hypertension increases).Salicylates and glucocorticosteroids reduce the risk of side effects.Kolestyramine, colestipol, mineral oils, neomycin reduce absorption of vitamin A (an increase in dose may be required).Oral contraceptives increase the concentration of vitamin A in the plasma.Isotretiine increases the risk of toxic effects.Weaken the effect of Ca preparations, increase the risk of hypercalcemia.Vitamin E reduces toxicity, absorption, deposition in the liver and the use of vitamin A; high doses of vitamin E can reduce the supply of vitamin A in the body. Special instructions:Do not take at the same time other multivitamin complexes containing vitamin A, in order to avoid an overdose. Form release / dosage:Capsules 33000 ME. Packaging:For 25 or 50 capsules in cans of glass mass, sealed with polyethylene caps, or in polymer cans.10 capsules per contour cell packaging made of polyvinylchloride film and aluminum foil.The bank or 1, 2, 3 or 5 contour squares, together with the instructions for use, are placed in a pack of cardboard. 150 contour mesh packages, together with an equal number of instructions for use, are placed in a bag of polyethylene luminous film.Each package is packed in a carton box box (group packaging). Storage conditions:In a dry, protected from light place at a temperature of no higher than 25 ° C. Keep out of the reach of children. Shelf life:2 years.Do not use after the expiration date. Terms of leave from pharmacies:Without recipe Registration number:LSR-002668/08 Date of registration:10.04.2008 The owner of the registration certificate:MARBIOFARM, OJSC MARBIOFARM, OJSC Russia Manufacturer: & nbspMARBIOFARM, OJSC Russia Representation: & nbspMARBIOFARM, OJSCMARBIOFARM, OJSC Information update date: & nbsp05.08.2015 Illustrated instructions × Illustrated instructions Instructions