Active substanceRetinolRetinol Similar drugsTo uncover Widestim® ointment externally RETYNOIDS FNPP, CJSC Russia Retinol capsules ALTAYVITAMINS, CJSC Russia Retinol pills inwards VEROPHARM SA Russia Retinol acetate solution inwards externally TECHNOLOG, PAO Ukraine Retinol acetate drops inwards externally PHARMACEUTICAL FACTORY of St. Petersburg, JSC Russia Retinol acetate solution inwards externally MARBIOFARM, OJSC Russia Retinol acetate capsules inwards externally MARBIOFARM, OJSC Russia Retinol acetate solution inwards MUROMSKY INSTRUMENT-MAKING PLANT, FSUE Russia Retinol acetate (Vitamin A) capsules inwards LYUMI, LLC Russia Retinol acetate (vitamin A) capsules inwards LYUMI, LLC Russia Retinol acetate (vitamin A) capsules inwards TULA PHARMACEUTICAL FACTORY, LTD. Russia Retinol acetate solution in oil solution inwards PHARMACEUTICAL FACTORY of St. Petersburg, JSC Russia Retinola palmitate pills inwards MARBIOFARM, OJSC Russia Retinola palmitate solution inwards RETYNOIDS FNPP, CJSC Russia Dosage form: & nbspCapsules. Composition:Composition for 1 capsule. Retinol acetate (vitamin A) 3,3 thousand ME 5 thousand ME solution in oil 8,6 % Auxiliary substances: 0,0132 ml 0,0200 ml Oils of soy hydrated Capsule shell: before 0,05 g before 0,05 g Gelatin 15.133 mg 15,133 mg Glycerol 4,766 mg 4,766 mg Methylparahydroxybenzoate 0,101 mg 0,101 mg Dye (green) 0,01 mg - Description:Capsules of a spherical form of green color (3,3 thousand ME) or yellow color (5 thousand ME), filled with oily liquid from light yellow to dark yellow color, without a rancid smell. Pharmacotherapeutic group:Vitamin. ATX: & nbspA.11.C.A Vitamin AA.11.C.A.01 Retinol Pharmacodynamics:Vitamin A has a restorative effect, normalizes tissue metabolism; participates in oxidation-reduction processes (due to a large number of unsaturated bonds), in the synthesis of mucopolysaccharides, proteins, lipids, in mineral metabolism, and cholesterol formation processes. Strengthens the production of lipase and trypsin, enhances myelopoiesis, cell division processes. Has a positive effect on the function of lacrimal, sebaceous and sweat glands; increases resistance to diseases of the mucous membranes of the respiratory tract and intestines; increases the body's resistance to infection. It enhances the division of skin epithelial cells, rejuvenates the cellular population, inhibits keratinization processes, enhances the synthesis of glycosaminoglycans, activates the interaction of immunocompetent cells with each other and epidermal cells. Stimulates skin regeneration.Participates in the processes of photoreception (contributes to the adaptation of man to the dark). Local action is due to the presence on the cell surface of the epithelium of specific retinol-binding receptors. Pharmacokinetics:Quickly absorbed from the gastrointestinal tract (mainly from the 12-finger and jejunum), the presence of bile acids, pancreatic lipase, proteins and fats is required. The connection with plasma proteins (lipoproteins) is normal - less than 5%; with excessive intake of vitamin A with food and overflow to the liver depot, its association with plasma lipoproteins can reach up to 65%. The amount of bound vitamin A with lipoproteins can increase with hyperlipoproteinemia. When released from the liver depot, the vitamin forms a complex with the retinol-binding protein, in the form of which circulates in the blood. In small amounts penetrates into breast milk and through the placenta. It is deposited in the liver (approximately in the amount of the biennial needs of the adult organism), in small amounts - in the kidneys, lungs. To mobilize vitamin A from the depot zinc-containing substances are required.Metabolised in the liver. It is excreted with feces (non-sucking part) and kidneys. Indications:Hypovitaminosis, avitaminosis A. In complex therapy:- Infectious-inflammatory diseases (measles, dysentery, influenza, tracheitis, bronchitis, etc.);- lesions and skin diseases (frostbite, burns, wounds, erosion, ulcers, cracks, ichthyosis, hyperkeratosis, seborrheic dermatitis, psoriasis, neurodermatitis, some forms of eczema, skin tuberculosis);- eye diseases (pigment retinitis, hemeralopia, xerophthalmia, keratomalacia, eczematous lesions of the eyelids);- gastrointestinal diseases (erosive gastroduodenitis, peptic ulcer of the stomach and duodenum). Contraindications:Hypersensitivity to the components of the drug, hypervitaminosis A, pregnancy, cholelithiasis, chronic pancreatitis, acute inflammatory skin diseases, children's age. Carefully:Applied with nephritis, heart failure II-III, alcoholism, cirrhosis, viral hepatitis, renal failure, elderly age. Dosing and Administration:The drug is administered orally early in the morning or late in the evening (10-15 minutes after eating).Therapeutic doses for adults with avitaminosis of mild and moderate severity are up to 33000 IU / day.In case of eye diseases, adults are assigned 50000-100000 IU per day and simultaneously 0.02 grams of riboflavin.When skin diseases are prescribed to adults per day for 50000-100000 ME retinol acetate.The daily intake for adults should not exceed 100,000 ME. Side effects:Prolonged daily intake of vitamin A (200000 ME - adults) can cause intoxication, hypervitaminosis A. Symptoms of hypervitaminosis A in adults - headache, drowsiness, lethargy, hyperemia of the face, nausea, vomiting, tenderness in the bones of the lower extremities, gait disturbance. Overdose:Symptoms of acute overdose (develop 6 hours after the introduction): hypervitaminosis A: in adults - drowsiness, lethargy, double vision, dizziness, severe headache, nausea, severe vomiting, diarrhea, irritability, osteoporosis, gingival hemorrhage, dryness and ulceration of the mucosa shells of the mouth, exfoliation of the lips, skin, (especially the palms), confusion, increased intracranial pressure.Symptoms of chronic intoxication: loss of appetite, bone pain, cracks and dry skin, dryness of the oral mucosa, gastralgia, vomiting, hyperthermia, asthenia, excessive fatigue, discomfort,headache, photosensitivity, pollakiuria, nocturia, polyuria, irritability, hair loss, yellow-orange spots on the soles, palms, in the nasolabial triangle, hepatotoxic phenomena, intraocular hypertension, oligomenorrhoea, portal hypertension, hemolytic anemia, changes in bone radiographs, convulsions. Treatment: withdrawal of the drug, symptomatic therapy. Interaction:Weaken the effect of calcium preparations, increases the risk of hypercalcemia. Kolestyramine, colestipol, mineral oils, neomycin reduce absorption of vitamin A (you may need to increase its dose).Oral contraceptives increase the concentration of vitamin A in the plasma. Isotretinoin increases the risk of toxic effects.Simultaneous use of tetracycline and vitamin A in high doses (50 thousand units or more) increases the risk of developing intracranial hypertension.Vitamin E reduces toxicity, absorption, deposition in the liver and the use of vitamin A; high doses of vitamin E can reduce the supply of vitamin A in the body. Special instructions:Do not take at the same time other multivitamin complexes containing vitamin A, in order to avoid an overdose. Form release / dosage:Capsules 3,3 thousand ME, 5 thousand ME. Packaging:For 10 or 20 capsules in a contour mesh box made of polyvinylchloride film and paper with a polymer coating or foil of aluminum printed lacquered.By 2, 3, 4 contour mesh packs together with instructions for use are placed in a pack of cardboard.For 10, 20, 50 contour squares, together with instructions for use, are placed in a sealed polyethylene hermetically sealed packet of light-tight polyethylene film.It is allowed to apply instructions for use on the package.For 100, 200, 400, 600 contour mesh packages, together with an equal number of instructions for use, are placed in a sealed polyethylene hermetically sealed packet of light-tight polyethylene film.Polyethylene packaging is placed in a cardboard box.For hospitals 100, 200, 400, 600 contour cells, together with the instruction for use, are placed in a cardboard box. Storage conditions:List B. In dry the dark place at a temperature of no higher than 25 0C. Keep out of the reach of children. Shelf life:2 years.Do not use after expiry date. Terms of leave from pharmacies:Without recipe Registration number:LSR-004225/09 Date of registration:28.05.2009 The owner of the registration certificate:LYUMI, LLC LYUMI, LLC Russia Manufacturer: & nbspLYUMI, LLC Russia Representation: & nbspLYUMI, LLCLYUMI, LLC Information update date: & nbsp05.08.2015 Illustrated instructions × Illustrated instructions Instructions