Active substanceRetinolRetinol Similar drugsTo uncover Widestim® ointment externally RETYNOIDS FNPP, CJSC Russia Retinol capsules ALTAYVITAMINS, CJSC Russia Retinol pills inwards VEROPHARM SA Russia Retinol acetate solution inwards externally TECHNOLOG, PAO Ukraine Retinol acetate drops inwards externally PHARMACEUTICAL FACTORY of St. Petersburg, JSC Russia Retinol acetate solution inwards externally MARBIOFARM, OJSC Russia Retinol acetate capsules inwards externally MARBIOFARM, OJSC Russia Retinol acetate solution inwards MUROMSKY INSTRUMENT-MAKING PLANT, FSUE Russia Retinol acetate (Vitamin A) capsules inwards LYUMI, LLC Russia Retinol acetate (vitamin A) capsules inwards LYUMI, LLC Russia Retinol acetate (vitamin A) capsules inwards TULA PHARMACEUTICAL FACTORY, LTD. Russia Retinol acetate solution in oil solution inwards PHARMACEUTICAL FACTORY of St. Petersburg, JSC Russia Retinola palmitate pills inwards MARBIOFARM, OJSC Russia Retinola palmitate solution inwards RETYNOIDS FNPP, CJSC Russia Dosage form: & nbspSolution for oral administration [oily] Composition:In 1 ml of the solution contains about 100,000 ME retinol palmitate (1 drop of the drug from a dropper or eye dropper contains retinol palmitate about 3300 IU). 1 mg of retinol palmitate corresponds to 1817 IU. Description:Transparent oily liquid from light yellow to yellow without rancid smell. Pharmacotherapeutic group:Vitamin. ATX: & nbspA.11.C.A Vitamin AA.11.C.A.01 Retinol Pharmacodynamics:Vitamin A has a general strengthening effect, normalizes tissue metabolism, participates in oxidation-reduction processes (due to a large number of unsaturated bonds), in the synthesis of mucopolysaccharides, proteins, lipids, in mineral metabolism, and cholesterol formation processes. Strengthens the production of lipase and trypsin, enhances myelopoiesis, cell division processes. Has a positive effect on the function of lacrimal, sebaceous and sweat glands; increases resistance to diseases of mucous membranes, respiratory tract and intestines; increases the body's resistance to infection. It enhances the division of skin epithelial cells, rejuvenates the cellular population, inhibits keratinization processes, enhances the synthesis of glycosaminoglycans, activates the interaction of immunocompetent cells with each other and epidermal cells. Stimulates the regeneration of cells. Participates in the processes of photoreception (contributes to the adaptation of man to the dark).Local action is due to the presence on the cell surface of the epithelium of specific retinol-binding receptors. Indications:Hypovitaminosis, avitaminosis A. In complex therapy:- Infectious and inflammatory diseases (measles, dysentery, influenza, tracheitis, bronchitis, etc.)- skin diseases and lesions (cracks, ichthyosiform erythroderma, acne, hyperkeratosis, seborrhoeic dermatitis, psoriasis, atopic dermatitis, some forms of eczema, lupus)- eye diseases (pigment retinitis, hemeralopia, xerophthalmia, keratomalacia, eczematous lesions of the eyelids),- gastrointestinal diseases (erosive gastroduodenitis, gastric ulcer and duodenal ulcer),cirrhosis of the liver.Assign to prevent the formation of concrements in the biliary and urinary tract. Contraindications:Hypersensitivity to the components of the drug, hypervitaminosis A, pregnancy, cholelithiasis, chronic pancreatitis, acute inflammatory skin diseases. Carefully:Use in nephritis, heart failure II-III st., Alcoholism, viral hepatitis, renal failure, advanced age, children's age. Pregnancy and lactation:It is not recommended to take the drug during pregnancy and breastfeeding. Dosing and Administration:The drug should be used under medical supervision. The drug is taken orally after meals early in the morning or late in the evening.Therapeutic doses for adults with avitaminosis of mild and moderate severity are up to 33000 IU / day, for children - 1000-5000 IU / day, depending on the age.In case of eye diseases, adults are assigned 50000-100000 IU per day and simultaneously 0.02 grams of riboflavin.In dermatology in the treatment of acne and ichthyosiform erythrodermia in adults, 100,000-300,000 IU / day, children 5,000-10000 IU / kg per day.When skin diseases are prescribed for adults per day for 50000-100000 ME retinol palmitate.In gastroenterology - for 50000 ME per day.Single doses of retinol palmitate should not exceed 50,000 ME for adults and 5,000 ME for children. The daily doses for adults are 100,000 ME and 20,000 ME for children. For the treatment of acne and ichthyosiform erythrodermia in adults, 100,000-300,000 ME. Side effects:In some patients with prolonged admission, dry skin and mucous membranes, increased sensitivity of the facial skin, seizures. The indicated phenomena pass independently at dose reduction or temporary cancellation of the drug.In the treatment of acne, after 7-10 days of admission, there is an exacerbation of the local inflammatory reaction, which does not require additional treatment and subsequently ceases. In some cases intolerance of the drug is noted, which requires its withdrawal. Overdose:Prolonged daily intake of vitamin A (100,000 ME for children, 200,000 ME for adults) can cause intoxication, hypervitaminosis A. Symptoms of hypervitaminosis A in adults-headache, drowsiness, lethargy, hyperemia of the face, nausea, vomiting, tenderness in the bones of the lower limbs, gait disturbance . Children can be observed: fever, drowsiness, sweating, vomiting, skin rashes. When symptoms of an overdose occur, the drug should be discarded. Excess of retinol palmitate is excreted from the body by ingestion of alcohol. With severe symptoms of intoxication, glucocorticosteroids should be administered. Interaction:During prolonged therapy with tetracyclines, vitamin A is not recommended (the risk of developing intracranial hypertension increases).Salicylates and glucocorticosteroids reduce the risk of side effects. Kolestyramine, colestipol, mineral oils, neomycin reduce absorption of vitamin A (a dose increase may be required).Oral contraceptives increase the concentration of vitamin A in the plasma.Isotretinoin increases the risk of toxic effects.Vitamin E reduces toxicity, absorption, deposition in the liver and the use of vitamin A; high doses of vitamin E can reduce the supply of vitamin A in the body.Weaken the effect of calcium preparations, increases the risk of hypercalcemia. Special instructions:Do not take simultaneously multivitamin complexes containing vitamin A, in order to avoid an overdose. Form release / dosage:Solution for oral administration 100000 IU / ml. Packaging:By 10, 15, 20, 30, 50, 100, 150 and 200 ml in bottles of dark glass. For 10, 15, 20, 30, 50, 100 ml in bottles for drops of dark glass, complete with a dropper and 150, 200 ml in bottles for drops of dark glass. Each vial with instructions for medical use in a pack of cardboard. Storage conditions:In the dark place at a temperature of no higher than 10 0C.Keep out of the reach of children. Shelf life:2 years. Do not use after expiry date. Terms of leave from pharmacies:Without recipe Registration number:P N000550 / 01 Date of registration:12.11.2007 The owner of the registration certificate:RETYNOIDS FNPP, CJSC RETYNOIDS FNPP, CJSC Russia Manufacturer: & nbspRETYNOIDS FNPP, CJSC Russia Information update date: & nbsp06.08.2015 Illustrated instructions × Illustrated instructions Instructions