Cordiamine (Cordiamin)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceNitcheamideNitcheamide
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    • Dosage form: & nbspdrops for oral administration
    Composition:

    Active substance:

    Niketamide (diethylamide of nicotinic acid in terms of 100%) - 250 g

    Excipient:

    Purified water - up to 1 liter

    Description:Transparent or slightly opalescent colorless or slightly colored liquid with a peculiar odor.
    Pharmacotherapeutic group:Analeptic remedy
    ATX: & nbsp

    R.07.A.B   Respiratory stimulants

    R.07.A.B.02   Nitcheamide

    Pharmacodynamics:

    Analeptic agent of mixed type of action (stimulation of the central nervous system, direct and reflex excitation of the respiratory and vasomotor centers). The mechanism of action consists of 2 components: central and peripheral. The central mechanism is associated with a direct effect on the vasomotor center of the medulla oblongata, leading to its excitation and mediated increase in systemic arterial pressure (especially when the center is initially oppressed). The peripheral component of the mechanism of action is associated with the excitation of chemoreceptors of the carotid sinus, which leads to an increase in the frequency and depth of respiratory movements. There is no direct influence on the cardiovascular system.

    Pharmacokinetics:

    Absorption is high, does not depend on the route of administration. It is subject to rapid metabolism in the liver with the formation of inactive metabolites. Excretion mainly by the kidneys.

    Indications:Collapse, asphyxia, shock, circulatory and respiratory disorders in infectious diseases. Use as directed by a doctor.
    Contraindications:

    Hypersensitivity, predisposition to convulsions, epilepsy, tonic-clonic convulsions (including in anamnesis), hyperthermia in children; pregnancy, the period of breastfeeding.

    Pregnancy and lactation:During pregnancy and during breastfeeding, the prescription of the drug is possible if the potential benefit to the mother exceeds the possible risk to the fetus.
    Dosing and Administration:

    Inside, regardless of food intake.

    At a collapse, asphyxia, a shock, infringements of a circulation and breath at infectious diseases:

    Adults on 15-40 drops 2-3 times a day. The highest single dose for adults is 60 drops, daily-180 drops.

    Children under 10 years - the number of drops equal to the number of years, 2-3 times a day.

    Children from 10 years, 10 drops 2-3 times a day.

    Side effects:Anxiety, anxiety, muscle twitching (starting with the circular muscles of the mouth), flushing of the skin of the face, itching of the skin, vomiting, arrhythmias, allergic reactions.
    Overdose:Increased severity of side effects. Tonic-clonic convulsions. Treatment is symptomatic.
    Interaction:

    Strengthens the effects of psychostimulants, antidepressants.Reduces the effects of narcotic analgesics, hypnotics, antipsychotic drugs (neuroleptics), anxiolytics, antiepileptic drugs.

    The effect is reduced aminosalicylic acid, opiniazide, phenothiazine derivatives and drugs for general anesthesia.

    Convulsive effect of the drug strengthens reserpine.

    Due to the high risk of developing toxic reactions when administering effective doses, the use of poison drugs, narcotic analgesics and barbiturates is contraindicated.

    Form release / dosage:

    Drops for ingestion 250 mg / ml.

    Packaging:

    To 30 ml in bottles of orange glass with a screw mouth, sealed with stoppers-droppers plastic and caps screwed.

    Each bottle, together with the instructions for use, is placed in a pack of cardboard.

    Storage conditions:

    In the dark place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:3 years. Do not use after the time specified on the package.
    Terms of leave from pharmacies:Without recipe
    Registration number:LP-001000
    Date of registration:18.10.2011
    Expiration Date:Unlimited
    The owner of the registration certificate:TULA PHARMACEUTICAL FACTORY, LTD. TULA PHARMACEUTICAL FACTORY, LTD. Russia
    Manufacturer: & nbsp
    Information update date: & nbsp23.11.2017
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