Cordiamin - instructions for use, doses, side effects, contraindications

Analeptic agent of mixed action. The mechanism of action is composed of central and peripheral effects on the nervous system. The central mechanism is associated with a direct influence on the vasomotor center of the medulla oblongata, leading to its excitation and mediated increase in blood pressure (especially when the center is initially oppressed).

Peripheral effect is due to excitation of carotid sinore chemoreceptors, which leads to an increase in the frequency and depth of respiratory movements. Direct influence on the cardiovascular system does not.

Pharmacokinetics:Absorption is high and does not depend on the route of administration. It is subject to rapid metabolism in the liver with the formation of inactive metabolites, derived mainly by the kidneys.

Indications:

Collapse, asphyxia (including newborns), shock during surgical operations and in the postoperative period, respiratory depression and blood circulation in infectious diseases.

Contraindications:

Hypersensitivity to the components of the drug;

Reduction of the convulsive threshold, convulsions (including in the anamnesis);

Hyperthermia in children;

Pregnancy, lactation.

Pregnancy and lactation:

There are no reliable data on the safety of use of the drug during pregnancy and lactation. It is not recommended to use this medication during pregnancy and lactation.

Dosing and Administration:

The drug is administered intravenously, intramuscularly and subcutaneously.

Adults and children over 14 years of age are administered subcutaneously, intramuscularly and intravenously at a dose of 1-2 ml 1-3 times per day.

Intravenous administration is slow.

Children - subcutaneously, depending on the age, in a dose of 0.1-0.75 ml.

Since subcutaneous and intramuscular injections of the drug Cordiamin are painful, in order to reduce pain, depending on the situation, the place of putative injection is preliminarily administered procaine (Novocain) 1 ml of a 0.5% solution.

Higher doses for adults subcutaneously: single - 2 ml, daily - 6 ml.

Side effects:

From the digestive system: vomiting.

From the nervous system: anxiety, muscle contractions (beginning with the circular muscles of the mouth).

From the skin: itching, flushing of the face.

From the side of the cardiovascular system: arrhythmia.

Other: pain at the injection site, allergic reactions.

Overdose:

Symptoms of overdose: increased severity of dose-dependent side effects, generalized tonic-clonic seizures.

Measures to assist in overdose: treatment is symptomatic (including anticonvulsant drugs).

Interaction:

Strengthens the effects of psychostimulants, antidepressants.

Reduces the effects of narcotic analgesics, hypnotics, antipsychotic and antiepileptic drugs, anxiolytics.

Reduces the effectiveness of niketamide: aminosalicylic acid, opiniazide, derivatives of phenothiazine and drugs for general anesthesia.

Convulsive effect of the drug strengthens reserpine and aminazine.

The pressure effect of niketamide is enhanced by the action of monoamine oxidase inhibitors.

Effect on the ability to drive transp. cf. and fur:

On a background of treatment by a preparation it is necessary to be cautious at management of vehicles, mechanisms.

Form release / dosage:

Solution for injection 250 mg / ml to 1 ml or 2 ml in the ampoule.

Packaging:

5 ampoules in a contour mesh package made of a polyvinylchloride (PVC) or polyethylene terephthalate (PET) film.

1 or 2 contour mesh packages together with the instruction for use and the ampoule scarifier are placed in a pack of cardboard for consumer packaging or imported.

5 or 10 ampoules together with the instruction for use and the ampoule scarifier are placed in a pack of cardboard for consumer packaging with a corrugated liner. When using ampoules with a dot or a ring of fracture, the ampoule scaper is not inserted.

Packing for hospitals.

For 4, 5 or 10 contour packagings together with instructions for use in an amount equal to the number of contiguous cell packs, put in a pack of cardboard for consumer containers.

For 50, 100 contour cell packs with ampoules together with an equal number of instructions for use are placed in a box of corrugated cardboard.

Storage conditions:

Store in a dark place at a temperature of no higher than 25 ° C, out of the reach of children.

Shelf life:

3 years. Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:LP-002391

Date of registration:03.03.2014 / 24.06.2016

Expiration Date:03.03.2019

The owner of the registration certificate:ELLARA, LTD. ELLARA, LTD. Russia

Manufacturer: & nbsp

ELLARA, LTD. Russia

Information update date: & nbsp23.11.2017

Illustrated instructions

Instructions

Cordiamine (Cordiamin)