Cordiamin - instructions for use, doses, side effects, contraindications

Analeptic means of a mixed type of action (stimulation of the central nervous system, direct and reflex excitation of the respiratory and vasomotor centers). The mechanism of action consists of two components: central and peripheral.

The central mechanism is associated with a direct effect on the vasomotor center of the medulla oblongata, leading to its excitation and mediated increase in systemic arterial pressure (especially when the center is initially oppressed).

The peripheral component of the mechanism of action is associated with the excitation of chemoreceptors of the carotid sinus, which leads to an increase in the frequency and depth of respiratory movements. Direct influence on the cardiovascular system does not.

Pharmacokinetics:

Absorption is high, does not depend on the route of administration. It is subject to rapid metabolism in the liver with the formation of inactive metabolites. Excretion, mainly by the kidneys.

Indications:

Collapse, asphyxia (including newborns), shock during surgical operations and in the postoperative period, respiratory depression and blood circulation in infectious diseases.

Contraindications:

Hypersensitivity, lowering the threshold of convulsive readiness, convulsions in the anamnesis, hyperthermia in children, pregnancy, the period of breastfeeding.

Pregnancy and lactation:

The drug is contraindicated in pregnancy and during breastfeeding. If you need the use of cordiamine, you should decide whether to stop breastfeeding.

Dosing and Administration:

Single and daily doses, the frequency of administration are set individually by the doctor depending on the indications and age of the patient.

The drug is administered subcutaneously, intramuscularly and intravenously. Adults and children over 14 years of age are prescribed 1-2 ml 1-3 times a day.

For intravenous administration, a single dose of the drug is diluted in 10 ml of 0.9% sodium chloride solution; inject 1-3 min.

Higher doses for adults subcutaneously: single - 2 ml, daily - 6 ml.

Children are prescribed subcutaneously, depending on the age, such single doses:

up to 1 year - 0.1 ml;

1-4 years - 0,15-0,25 ml;

5-6 years - 0.3 ml;

7-9 years - 0.5 ml;

10-14 years - 0,75 ml.

Enter 1-3 times a day.

Side effects:

Impaired nervous system: anxiety, increased irritability, anxiety.

Disorders from the gastrointestinal tract: nausea, vomiting.

Violations from the heart and blood vessels: arrhythmia, arterial hypertension, tachycardia.

Disturbances from the musculoskeletal and connective tissue: muscle twitching (starting with the circular muscles of the mouth), tremor, rigidity of the muscles.

Disturbances from the skin and subcutaneous tissues: redness, facial swelling, skin peeling.

General disorders and disorders at the site of administration: hyperthermia, excessive sweating, infiltration, tenderness, hyperemia, itching, burning sensation at the injection site.

Immune system disorders: hypersensitivity reactions, including hives, angioedema, generalized papular rashes.

Overdose:

Symptoms: increased severity of dose-dependent adverse reactions, tonic-clonic convulsions.

Treatment: symptomatic.

Interaction:

Enhances the effects of psychostimulants and antidepressants.

Reduces the effects of narcotic analgesics, hypnotics, neuroleptics, tranquilizers, anticonvulsants.

Under the influence of paraaminosalicylic acid, saluside, phenothiazine derivatives (aminazine, etc.), the analeptic effect of niketamide decreases.

Under the influence of monoamine oxidase inhibitors, the pressor effect of niketamide is enhanced.

Nitacamide contributes to the development of intolerance to phytivazide. The convulsive action of niketamide enhances reserpine, aminazine.

Against a background of deep anesthesia nikethamide It does not work.

Effect on the ability to drive transp. cf. and fur:

During the treatment period it is necessary to refrain from driving vehicles and working with mechanisms in view of the possible development of undesirable reactions that may affect these activities (see Adverse Effect).

Form release / dosage:

Solution for injection 250 mg / ml.

Packaging:

By 1 or 2 ml into ampoules of colorless glass. 5 ampoules are placed in a contour cell pack.

1 or 2 contour squares, together with instructions for use, are placed in a pack of cardboard.

Storage conditions:

In the dark place at a temperature of 2 to 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:LP-004558

Date of registration:27.11.2017

Expiration Date:27.11.2022

The owner of the registration certificate:TATHIMFARMPREPARATY, JSC TATHIMFARMPREPARATY, JSC Russia

Manufacturer: & nbsp

RUSSIAN CARDIOLOGICAL NPK FGU ROSMEDTEKHNOLOGIY - EXPERIMENTAL PRODUCTION OF MEDICAL AND BIOLOGICAL PREPARATIONS Russia

Information update date: & nbsp09.01.2018

Illustrated instructions

Instructions

Cordiamine (Cordiamin)