Active substanceNitcheamideNitcheamide
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  • Dosage form: & nbspinjection
    Composition:

    Diethylamide of nicotinic acid (in terms of 100%) or niketamid - 250 grams, water for injection - up to 1 liter.

    Description:Colorless or slightly colored transparent liquid with a peculiar smell.
    Pharmacotherapeutic group:Analeptic remedy
    ATX: & nbsp

    R.07.A.B   Respiratory stimulants

    R.07.A.B.02   Nitcheamide

    Pharmacodynamics:

    Has an analeptic effect. Stimulates the central nervous system: it has an exciting effect on the vasomotor center of the medulla oblongata (especially when the center is oppressed), which leads to an indirect increase in systemic blood pressure. Excites the respiratory center due to the stimulating effect on the chemoreceptors of the sinocarotid reflexogenic zone, which leads to an increase in the frequency and depth of the respiratory movements. The drug has no direct stimulating effect on the heart and a direct stimulating vasoconstrictor effect.

    Pharmacokinetics:Well absorbed in any route of administration. It is subject to rapid biotransformation in the liver with the formation of inactive metabolites, excreted mainly by the kidneys.
    Indications:

    Collapse, shock conditions during surgical operations and in the postoperative period, cardiac disorders, decreased vascular tone, weakened breathing in infectious diseases and during recovery, asphyxia of newborns, poisoning with narcotic, hypnotics and analgesics.

    Contraindications:Hypersensitivity, epilepsy, seizures of tonic-clonic seizures in the anamnesis, hyperthermia in children, pregnancy, lactation.
    Pregnancy and lactation:The use of the drug during pregnancy and during breastfeeding is contraindicated. For the duration of treatment, stop breastfeeding.
    Dosing and Administration:

    Adults injected subcutaneously, intramuscularly and intravenously in a dose of 1-2 ml 1-3 times a day; Children - subcutaneously, depending on age, in a dose of 0.1 - 0.75 ml. Intravenous administration is slow.

    With intoxication with drugs, analgesics, hypnotic adults, intravenously (can be subcutaneously or intramuscularly) inject 3-5 ml of the drug.

    Since subcutaneous and intramuscular injections of cordiamine are painful, novocaine (1 ml of a 0.5% solution) is pre-injected at the injection site to reduce pain, depending on the situation.

    Higher doses for adults subcutaneously: single - 2 ml, daily - 6 ml. The highest single dose for subcutaneous and intravenous administration for drug poisoning is 5 ml.

    Side effects:

    Anxiety, anxiety, muscle twitching (starting with the circular muscles of the mouth), tonic-clonic convulsions,allergic reactions, itching of the skin, facial hyperemia, vomiting, disturbance of the heart rhythm, infiltration and soreness at the injection site.

    Overdose:Tonic-clonic convulsions.
    Interaction:

    The convulsive effect of Cordiamin strengthens reserpine, the exciting effect on the respiratory center is eliminated by means for anesthesia, the action of the drug weakens PASK and saluside, aminazine and other phenothiazine derivatives lead to an attenuation of the analeptic effect and convulsive effect.

    Enhances the effects of psychostimulants and antidepressants. Reduces the effects of narcotic analgesics, hypnotics, neuroleptics, tranquilizers, anticonvulsants.

    Effect on the ability to drive transp. cf. and fur:During the period of treatment it is necessary to refrain from driving motor vehicles and practicing potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.
    Form release / dosage:

    Solution for injection 250 mg / ml.

    Packaging:

    Producer OJSC "Moshimfarmpreparaty" them. ON. Semashko ":

    1 or 2 ml into neutral glass ampoules.

    10 ampoules are placed in a box of cardboard.

    In each box, an ampoule ceramic scaler or ampoule abrasive scarifier and instructions for use are enclosed.

    Boxes are pasted with a label-parcel post.

    When using ampoules with a dot or a ring of fracture, the scarifier is not inserted.

    5 ampoules are placed in a contour mesh package made of a polyvinyl chloride film.

    2 contour mesh packages together with instructions for use and a scarifier ampoule ceramic or scarifier ampoule abrasive are placed in a pack of cardboard.

    Producer OJSC Novosibkhimpharm:

    1 or 2 ml into neutral glass ampoules.

    For 10 ampoules with instruction for use and a knife for opening ampoules or a scarifier ampullum is placed in a box of cardboard.

    5 or 10 ampoules are placed in a contoured cell pack of a polyvinylchloride film or polyethylene terephthalate tape and aluminum foil or paper with a polyethylene coating or without a foil, or without paper.

    For 1 or 2 contour cells (5 ampoules each) or 1 circuit pack (10 ampoules each) with instructions for use and a vial for opening ampoules or a scarifier ampoule is placed in a pack of cardboard.

    Packing for hospitals

    For 50 or 100 contour cell packs, together with an equal number of instructions for medical use are placed in a box of cardboard.

    When you pack the ampoules with a break ring or break point, the ampoule opener or ampoule scapper is not put in.

    Storage conditions:

    In the dark place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:3 years. Do not use after the expiration date.
    Terms of leave from pharmacies:On prescription
    Registration number:P N003853 / 01
    Date of registration:09.11.2009 / 19.08.2015
    Expiration Date:Unlimited
    The owner of the registration certificate:MIKFARM, LLCMIKFARM, LLC
    Manufacturer: & nbsp
    Information update date: & nbsp23.11.2017
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