Cordiamin - instructions for use, doses, side effects, contraindications

Has an analeptic effect. Stimulates the central nervous system: it exerts an excitatory effect on the suction to the motor center of the medulla oblongata (especially when the center is oppressed), which leads to an indirect increase in systemic blood pressure. Excites the respiratory center due to the stimulating effect on the chemoreceptors of the sinocarotid reflexogenic zone, which leads to an increase in the frequency and depth of the respiratory movements. The drug has no direct stimulating effect on the heart and a direct stimulating vasoconstrictor effect.

Pharmacokinetics:Well absorbed in any route of administration. It is subject to rapid biotransformation in the liver with the formation of inactive metabolites, excreted mainly by the kidneys.

Indications:

Collapse, shock conditions during surgical operations and in the postoperative period, cardiac disorders, decreased vascular tone, weakened breathing in infectious diseases and during recovery, asphyxia of newborns, poisoning with narcotic, hypnotics and analgesics.

Contraindications:Hypersensitivity, epilepsy, seizures of tonic-clonic seizures in the anamnesis, hyperthermia in children, pregnancy, lactation.

Dosing and Administration:

Adults injected subcutaneously, intramuscularly and intravenously in a dose of 1-2 ml 1-3 times a day; Children - subcutaneously, depending on age, in a dose of 0.1 - 0.75 ml. Intravenous administration is slow.

With intoxication with drugs, analgesics, hypnotic adults, intravenously (can be subcutaneously or intramuscularly) inject 3-5 ml of the drug.

Since subcutaneous and intramuscular injections of cordiamine are painful, novocaine (1 ml of 0.5% solution) is pre-injected to reduce the pain, depending on the situation.

Higher doses for adults subcutaneously: single - 2ml, daily - 6ml. The highest single dose for subcutaneous and intravenous administration for drug poisoning is 5 ml.

Side effects:

Anxiety, anxiety, muscle twitching (starting with the circular muscles of the mouth), tonic-clonic convulsions, allergic reactions, itching of the skin, facial hyperemia, vomiting, disturbance of the heart rhythm, infiltration and soreness at the injection site.

Overdose:Tonic-clonic convulsions.

Interaction:

The convulsive effect of Cordiamin strengthens reserpine, the exciting effect on the respiratory center is eliminated by means for anesthesia, the action of the drug weakens PASK and saluside, aminazine and other phenothiazine derivatives lead to an attenuation of the analeptic effect and convulsive effect.

Enhances the effects of psychostimulants and antidepressants. Reduces the effects of narcotic analgesics, hypnotics, neuroleptics, tranquilizers, anticonvulsants.

Form release / dosage:Solution for injection 25%.

Packaging:In ampoules of 2 ml, 10 ampoules with instructions for use in a cardboard box.

Storage conditions:

List B. In protected from light inaccessible to children at a temperature of no higher than 25 ° C.

Shelf life:3 years. Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:P N003713 / 01

Date of registration:16.07.2009 / 13.09.2017

Expiration Date:Unlimited

The owner of the registration certificate:Promomed Rus, Open CompanyPromomed Rus, Open Company Russia

Manufacturer: & nbsp

BIOCHEMIST, OJSC Russia

Information update date: & nbsp23.11.2017

Illustrated instructions

Instructions

Cordiamine (Cordiamin)