Nitakamid-Eskom (Nikethamide-Eskom)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceNitcheamideNitcheamide
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    • Dosage form: & nbspinjection
    Composition:

    Active components: niketamide (in terms of dry matter) - 250.0 mg.

    Excipients: water for injection up to 1 ml.

    Description:Transparent colorless or slightly colored liquid with a peculiar smell.
    Pharmacotherapeutic group:an analeptic agent.
    ATX: & nbsp

    R.07.A.B   Respiratory stimulants

    R.07.A.B.02   Nitcheamide

    Pharmacodynamics:

    Analeptic agent of a mixed type of action (stimulation of the central nervous system (CNS), direct and reflex excitation of the respiratory and vasomotor centers). The mechanism of action is composed of their two components: central and peripheral. The central mechanism is associated with a direct effect on the vasomotor center of the medulla oblongata, leading to its excitation and mediated increase in systemic arterial pressure (BP) (especially when the center is initially oppressed). The peripheral component of the mechanism of action is associated with the excitation of chemoreceptors of the carotid sinus, which leads to an increase in the frequency and depth of respiratory movements. There is no direct effect on the cardiovascular system (CVS).

    Pharmacokinetics:Absorption is high, it does not depend on the route of administration. It is subject to rapid metabolism in the liver with the formation of inactive metabolites. Excretion mainly by the kidneys.
    Indications:

    Collapse, asphyxia (incl.newborns), shock conditions, circulatory and respiratory disorders in infectious diseases, poisoning with sleeping pills, narcotic analgesics, barbiturates.

    Contraindications:Hypersensitivity, predisposition to convulsions, epilepsy, epileptic seizures (at anamnesis), hyperthermia in children, pregnancy, lactation.
    Pregnancy and lactation:contraindicated
    Dosing and Administration:

    Adults are injected subcutaneously, intramuscularly and intravenously in a dose of 1-2 ml 1-3 times a day. Intravenous administration is slow. Children - subcutaneously, depending on the age, at a dose of 0.1 - 0.75 ml. When intoxication with drugs, analgesics, hypnotic adults, intravenously (can be subcutaneously or intramuscularly), inject 3-5 ml of the drug. Since subcutaneous and intramuscular injections of niketamide are painful, to reduce pain, depending on the situation, the injection site is first introduced procaine (1 ml of a 0.5% solution). Higher doses for adults subcutaneously: single - 2 ml, daily - 6 ml. The highest single dose for subcutaneous and intravenous administration for drug poisoning is 5 ml.

    Side effects:

    Anxiety, muscle twitching (starting with the circular muscles of the mouth), flushing of the facial skin, itching of the skin, vomiting, arrhythmias; infiltration and soreness at the injection site, allergic reactions.

    Overdose:Symptoms: increased severity of side effects, tonic-clonic convulsions. Treatment is symptomatic.
    Interaction:

    Strengthens the effects of psychostimulants, antidepressants. Reduces the effects of narcotic analgesics, hypnotics, antipsychotic drugs (drugs) (neuroleptics), anxiolytics, antiepileptic drugs. The effect reduces para- aminobenzoic acid, opiniazide, phenothiazine derivatives and drugs for general anesthesia. Convulsive effect of the drug strengthens reserpine.

    Special instructions:There is no information on the safety of use in lactating women.
    Form release / dosage:

    Solution for injection 250 mg / ml.

    1 ml of the drug in ampoules.

    5 or 10 ampoules are placed in a contour mesh package made of a polyvinyl chloride film.

    For 1 or 2 outline carton packs, together with the instructions for use are placed in a cardboard box.

    Packaging:(1) - ampoules (10) - contour plastic packaging (pallets)
    (1) - ampoules (5) - packings contour plastic (pallets)
    Storage conditions:

    List B. In the dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

    Shelf life:3 years. Do not use after the expiration date printed on the package.
    Terms of leave from pharmacies:Without recipe
    Registration number:LSR-001736/09
    Date of registration:10.03.2009
    The owner of the registration certificate:ESKOM NPK, OAO ESKOM NPK, OAO Russia
    Manufacturer: & nbsp
    Information update date: & nbsp09.08.2015
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