Cordiamin - instructions for use, doses, side effects, contraindications

Analeptic agent of mixed type of action. The mechanism of action consists of two components: central and peripheral. The central mechanism is associated with a direct effect on the vasomotor center of the medulla oblongata, leading to its excitation and mediated increase in systemic arterial pressure (especially when the center is initially oppressed). The peripheral component of the mechanism of action is associated with the excitation of chemoreceptors of the carotid sinus, which leads to an increase in the frequency and depth of respiratory movements. There is no direct influence on the cardiovascular system.

Pharmacokinetics:

Absorption is high, it does not depend on the route of administration. It is subject to rapid metabolism in the liver with the formation of inactive metabolites.

Excretion mainly by the kidneys.

Indications:Collapse, asphyxia (including newborns), shock conditions, circulatory and breathing disorders in infectious diseases, poisoning with sleeping pills, narcotic analgesics, barbiturates.

Contraindications:

Hypersensitivity to niketamidu, epilepsy, lowering the threshold of convulsive readiness, tonic-clonic convulsions in the anamnesis, hyperthermia in children, pregnancy, lactation.

Pregnancy and lactation:Contraindicated.

Dosing and Administration:

Subcutaneously, intramuscularly, intravenously: adults - 1-2 ml 2-3 times a day. Higher doses for adults: single dose - 2 ml, daily - 6 ml. Introduction to the vein is slow.

When poisoning with sleeping pills, narcotic analgesics, barbiturates - 3-5 ml. Subcutaneous and intramuscular injections are painful. To reduce pain in the place of the proposed injection, you can first "enter procaine.

Children - only subcutaneously, 0.1-0.75 ml, depending on the age.

Side effects:

Anxiety, muscle contractions (beginning with the circular muscles of the mouth), flushing of the facial skin, itching of the skin, vomiting, arrhythmias, infiltration and soreness at the injection site, allergic reactions.

Overdose:Symptoms - increased severity of side effects, tonic-clonic convulsions. Treatment is symptomatic.

Interaction:

Nitacamide enhances the effects of psychostimulants, antidepressants.

Nitacamid reduces the effect of narcotic analgesics, hypnotics, antipsychotic drugs (antipsychotics), anxiolytics, anti-epileptic drugs.

The effect of niketamide is reduced: paraaminosalicylic acid, opiniazide, phenothiazine derivatives and drugs for general anesthesia.

When used simultaneously with reserpine, the risk of developing seizures.

Form release / dosage:

Solution for injection 250 mg / ml.

Packaging:

By 1 ml or 2 ml into ampoules of type B of neutral glass or the type of neutral glass.

For 10 ampoules, together with the instruction for use and the ampoule opening opener or ampoule scarifier, is placed in a cardboard box.

5 ampoules per circuit cell box made of polyvinyl chloride film and foil of aluminum printed lacquered or foil-free.

2 contoured cell packs together with instructions for use and a knife for opening ampoules or a scarifier ampullum are placed in a pack of cardboard.

When using ampoules with incisions, rings and break points, a scarifier ampoule or a knife for opening ampoules is not inserted.

Storage conditions:

In the dark place at a temperature of 5 to 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:P N003665 / 01

Date of registration:04.06.2009 / 23.06.2010

Expiration Date:Unlimited

The owner of the registration certificate:DALHIMFARM, OJSC DALHIMFARM, OJSC Russia

Manufacturer: & nbsp

DALHIMFARM, OJSC Russia

Information update date: & nbsp23.11.2017

Illustrated instructions

Instructions

Cordiamine (Cordiamin)