Active substanceNitcheamideNitcheamide
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  • Dosage form: & nbspdrops for oral administration
    Composition:

    Active substance - nicotinic acid diethylamide (niketamide) - 250 g; auxiliary substance - water purified to 1 liter.

    Description:Transparent or slightly opalescent, colorless or slightly yellowish or greenish liquid with a peculiar odor.
    Pharmacotherapeutic group:Analeptic remedy
    ATX: & nbsp

    R.07.A.B   Respiratory stimulants

    R.07.A.B.02   Nitcheamide

    Pharmacodynamics:

    Analeptic agent of a mixed type of action (stimulation of the central nervous system, direct and reflex excitation, respiratory and vasomotor centers). The mechanism of action consists of 2 components: central and peripheral.

    The central mechanism is associated with a direct influence on the vasomotor center of the medulla oblongata, the brain, leading to its excitation and mediated elevated systemic arterial pressure (especially when the center is initially oppressed).

    The peripheral component of the mechanism-action is associated with the excitation of chemoreceptors of the carotid sinus, which leads to an increase in the frequency and depth of respiratory movements.

    There is no direct influence on the cardiovascular system.

    Pharmacokinetics:Absorption is high, it does not depend on the route of administration. It is subject to rapid metabolism in the liver with the formation of an inactive metabolite. Excretion mainly by the kidneys.
    Indications:

    Collapse, asphyxia (including newborns), shock, circulatory disorders and respiratory depression infectious diseases.

    Contraindications:

    Hypersensitivity, predisposition to convulsions, epilepsy, convulsions (including in anamnesis), hyperthermia in children.

    Carefully:Children should take the drug only under the supervision of a doctor.
    Pregnancy and lactation:

    Application of the drug during pregnancy and during breastfeeding contraindicationbut.

    Dosing and Administration:

    Inside, regardless of food intake.

    Adults - 15-40 drops 2-3 times a day. The highest single dose for adults is 60 drops, / daily-180 drops.

    Children under 10 years - the number of drops equal to the number of years, 2-3 times a day.

    Children from 10 years - 10 drops 2-3 times a day.

    Side effects:Anxiety, minor twitching (beginning with circular mouth muscles), hyperemia of the skin of the face, itching of the skin, vomiting, arrhythmias, allergic reactions.
    Overdose:Symptoms: tonic-clonic convulsions. Treatment: symptomatic.
    Interaction:

    Strengthens the effects of psychostimulants, antidepressants.

    Reduces the effects of narcotic analgesics, hypnotics, antipsychotic drugs(neuroleptics), anxiolytics, antiepileptic drugs.

    The effect reduces aminosalicylic acid, opiniazide, phenothiazine derivatives and drugs for general anesthesia.

    Convulsive effect of the drug strengthens reserpine.

    Effect on the ability to drive transp. cf. and fur:

    Use with caution when driving and other transport means.

    Form release / dosage:
    Drops for oral administration 25%.
    Packaging:For 15 ml, 25 ml or 30 ml in the bottles-dropper glass, 30 ml in bottles of glass. Each vial or flask-dropper along with the instruction for use is placed in a pack of cardboard.
    Storage conditions:

    In the dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

    Shelf life:

    3 years. Do not use after the time specified on the package.

    Terms of leave from pharmacies:Without recipe
    Registration number:LSR-004214/07
    Date of registration:22.09.2011 / 11.09.2012
    Expiration Date:Unlimited
    The owner of the registration certificate:TATHIMFARMPREPARATY, JSC TATHIMFARMPREPARATY, JSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp23.11.2017
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