Oxygen gaseous medical - instructions for use, dose, side effects, contraindications

Highly effective in hypoxic conditions. Significantly improves oxygen saturation of tissues and hemodynamics, protects the brain from hypoxia. Has a metabolic effect.

In conditions of normobaric hypoxia, it increases the resistance of the organism to endogenous and exogenous pathological factors.

Indications:

Hypoxia: with respiratory diseases (including pneumonia, bronchial asthma), diseases of the cardiovascular system (including chronic heart failure, collapse, arrhythmias, pulmonary edema).

Poisoning: carbon monoxide (carbon monoxide), hydrocyanic acid, asphyxiating substances (including chlorine, phosgene).

Weakened breathing in the postoperative period.

Ischemia of the lower extremities, trauma of the limbs.

Vascular diseases of the brain.

Hyperbaric oxygenation: during surgery on the heart and lungs, reconstructive surgery on the organs of the gastrointestinal tract, intoxication, anemia, gastric ulcer and duodenal ulcer, with chronic hepatitis.

Hypoxicotherapy: with coronary heart disease, arterial hypertension, diseases of the gastrointestinal tract, asthenia, depression, fatigue, in the state after radiation therapy.

Contraindications:

Hyperbaric oxygenation: in the presence of cavities in the lungs, unchanged pneumothorax, with bronchopleural fistula.

Violation of the patency of the auditory tubes and channels connecting the paranasal sinuses with the external environment.

Acute respiratory viral infections.

Epilepsy.

Arterial hypertension.

Neoplasms.

Carefully:

Hyperbaric oxygenation: with bronchial asthma, congenital spherocytosis, high fever, optic neuritis, upper respiratory tract infection, pregnancy, pulmonary emphysema, ear barotrauma, simultaneous administration of cisplatin, doxorubicin, disulfiram, mafenide (increasing the toxicity of these drugs).

Pregnancy and lactation:

Due to the lack of special clinical studies during pregnancy and breastfeeding, the drug should be used when the potential benefit to the mother exceeds the possible risk to the fetus and / or child and under the direct supervision of the doctor.

Dosing and Administration:

Inhalation, in a concentration of 40-60%, in a mixture with air, in an amount of 4-5 l / min. When breathing is weakened in the postoperative period, when poisoning, intoxication is used 100% oxygen or a mixture thereof with carbon dioxide (carbon dioxide).

Dosage regimen in all age groups, except for newborns, coincides.

To introduce oxygen in high and low concentrations, different equipment is used. The minimum concentration of oxygen should not be lower than its content in atmospheric air (20.9%).

Systems for inhalation with a fixed concentration of oxygen (regardless of the patient's breathing attempts): high flow - masks that provide oxygen supply at a high flow rate; low flow - anesthesia contours. In these systems, the oxygen concentration is set by the doctor.

Systems for inhalation, providing the supply of different concentrations of oxygen (depending on the patient's inspiration): without recycling - catheters and cannulas; with recirculation - oxygen masks. These systems work only in conditions of self-breathing of the patient who inhales the gas mixture. The oxygen content of the gas mixture will depend on the condition of the patient and the device used.

In newborns, the concentration of oxygen in the inhaled mixture should not exceed 40% (the risk of retrolental fibroplasia).

In elderly patients with chronic bronchitis, the inhaled oxygen concentration should be increased by 1% and not exceed 30% (most often).

Hyperbaric oxygenation: the procedure is carried out in special pressure chambers, for therapeutic purposes, use apparatus (single chamber), creating an oxygen pressure of 1.2-1.6-2.0 atm. Conduct 1 session per day (40-60 minutes), the course of treatment - 8-10 sessions.

With gastric ulcer and duodenal ulcer, chronic hepatitis is injected under a pressure of 0.7-1 excess atm. (sessions for 45 minutes); course of treatment - 15 sessions.

Hypoxicotherapy: special training, leading to oxygen deficiency (normobaric hypoxia) by using gas mixtures with a reduced oxygen content to create artificial hypoxia (at normal atmospheric pressure).

Side effects:

Oxygen therapy: myocardial ischemia in patients who underwent myocardial infarction.

Hyperbaric oxygenation: hypoglycemia, headache, numbness of fingers, transient visual impairment, ear barotrauma (ear pain, damage and rupture of the eardrum) and paranasal sinuses, fatigue, acceleration of cataract ripening; rarely - acute oxygen intoxication (convulsions, pulmonary edema).

Overdose:

With prolonged and unsystematic application of high concentrations of oxygen (over 60-80%) with a large flux (over 6-8 l / min) there is a danger of hyperoxygenation and as a consequence - pulmonary edema. With prolonged action of oxygen, decompensatory reactions develop, manifested by functional and structural disorders in various systems and organs.

Signs of oxygen intoxication appear after a certain period. Its duration may depend on individual sensitivity to oxygen, temperature and humidity of the environment,concentration in the inhaled gas mixture, emotional and physical loads, the state of the central nervous system, etc.

Treatment: symptomatic.

Interaction:Not investigated.

Special instructions:

In newborns, due to the increased risk of retinopathy, an increase in oxygen pressure above 0.079 atm is not recommended.

Effect on the ability to drive transp. cf. and fur:

In therapeutic doses Oxygen gaseous medical does not affect the ability to drive a car and perform work that requires increased attention.

Form release / dosage:

The gas is compressed.

Packaging:

0.31 m³ in a cylinder with a capacity of 2 dm³.

0.78 m³ in a cylinder with a capacity of 5 dm³.

1.56 m³ in a cylinder with a capacity of 10 dm³.

6,24 m³ in a cylinder with a capacity of 40 dm³.

The volume of the contents of the package is given for conditions: excess pressure (14.7 ± 0.5) MPa [(150 ± 0.5) kgf / cm²], temperature (20 ± 2) ° С.

The cylinder is equipped with an oxygen cylinder valve, a first-opening control device complete with instructions for medical use.

Storage conditions:

In a dry separate room or in open areas under a canopy, protecting from atmospheric precipitation and direct sunlight,away from heating sources and open fire sources at a temperature not exceeding 50 ° С.

Keep out of the reach of children.

Shelf life:

18 months from the date of manufacture.

Do not use after the expiry date indicated on the cylinder.

Terms of leave from pharmacies:For hospitals

Registration number:LP-002440

Date of registration:23.04.2014

Expiration Date:23.04.2019

The owner of the registration certificate:AUTOGEN PLANT, OJSC AUTOGEN PLANT, OJSC Russia

Manufacturer: & nbsp

AUTOGEN PLANT, OJSC Russia

Information update date: & nbsp10.01.2018

Illustrated instructions

Instructions

Oxygen gaseous medical (Medical gaseous oxygen)