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  • Dosage form: & nbspcompressed gas
    Composition:

    TOthe oxygen is 100%.

    Description:Colorless gas without a smell.
    Pharmacotherapeutic group:Antihypoxic agent
    ATX: & nbsp

    V.03.A.N   Medical gases

    Pharmacodynamics:

    Antihypoxant, enhances tissue oxygenation, improves hemodynamics and protects the brain from hypoxia. Has a metabolic effect.

    In conditions of normobaric hypoxia, it increases the resistance of the organism to endogenous and exogenous pathological factors.

    Indications:

    Hypoxia: with respiratory diseases (including pneumonia, bronchial asthma, pulmonary edema), cardiovascular system (including chronic heart failure, cardiopulmonary insufficiency, collapse, arrhythmia).

    Poisoning with carbon monoxide, hydrocyanic acid, asphyxiating substances (including chlorine, phosgene).

    Weakened breathing in the postoperative period.

    Ischemia of the lower extremities, trauma of the limbs.

    Vascular diseases of the brain.

    Hyperbaric oxygenation (heart and lung operations, reconstructive operations on the organs of the gastrointestinal tract (GIT), intoxication, anemia, peptic ulcer of the stomach and duodenum, chronic hepatitis).

    Hypoxicotherapy (coronary heart disease, arterial hypertension, gastrointestinal diseases, asthenia, depression, fatigue, condition after radiation therapy).

    Contraindications:

    Hyperbaric oxygenation (HBO) is contraindicated in the following cases: inflammatory processes in the nasopharynx, bronchus, lungs, ears, incl. against the background of ARVI (rhinitis, sinusitis, bronchitis, runny nose, tonsillitis, otitis, poor tolerance of flights in the airplane); presence of cysts and cavities in the lungs, bronchopleural fistula; unoccupied pneumothorax; neoplasms; disturbance of patency of auditory tubes and canals that connect the paranasal sinuses with the external environment; epileptic seizures or their equivalents (after head injuries, vascular, infectious brain damage); arterial hypertension; glaucoma, hemorrhages (fresh) on the fundus and proliferative changes in the vessels of the fundus (for diabetics it is necessary to have an ophthalmologist and a permit for HBO); the bleeding is active (only after stopping it).

    Carefully:

    Hyperbaric oxygenation is prescribed with caution in bronchial asthma, congenital spherocytosis, high fever, optic neuritis,upper respiratory tract infection, pregnancy, simultaneous administration of cisplatin, doxorubicin, disulfiram, mafenide (increasing the toxicity of these drugs), pulmonary emphysema, ear barotrauma.

    Pregnancy and lactation:

    It can be used in pregnancy and lactation if the potential benefit to the mother exceeds the possible risk to the fetus or the baby.

    Dosing and Administration:

    Inhalation, in a concentration of 40-60%, in a mixture with air, in an amount of 4-5 l / min.

    With a weakening of breathing in the postoperative period, with poisoning, intoxications use 100% oxygen or a mixture of carbonic acid. Inhalation is carried out through masks or tubes, attached by means of special devices to a cylinder with oxygen, or using rubber cushions.

    Hyperbaric oxygenation: procedure is carried out in special pressure chambers, for therapeutic purposes use apparatus (single-chamber), creating an oxygen pressure of 1.2-1.6-2 atm. Conduct 1 session per day (40-60 min), treatment course 8-10 sessions. With gastric ulcer and duodenal ulcer, chronic hepatitis is injected under a pressure of 0.7-1 excess atm.(sessions for 45 minutes); course of treatment - 15 sessions.

    Hypoxicotherapy: special training that leads to oxygen deficiency (normobaric hypoxia) by using gas mixtures with a reduced oxygen content to create an artificial hypoxia (at normal atmospheric pressure).

    Side effects:

    Hyperbaric oxygenation: hypoglycemia, headache, numbness of fingers, transient blurred vision, ear barotrauma (ear pain, and damage to the eardrum) and paranasal sinuses, fatigue, accelerating the maturation of cataracts, rarely - acute oxygen toxicity (convulsions, pulmonary edema).

    Oxygen therapy: Possible myocardial ischemia in patients who underwent myocardial infarction.
    Overdose:

    With prolonged and asymptomatic use of high concentrations of oxygen (over 60-80%) with a large flow (above 6-8 l / min) there is a danger of hyperoxygenation and as a consequence - pulmonary edema. With prolonged action of oxygen, decompensatory reactions develop, manifested by functional and structural disorders in various systems and organs. Signs of oxygen intoxication appear after a certain period.Its duration may depend on individual sensitivity to oxygen, temperature and humidity of the environment, concentration in the inspired gas mixture, emotional and physical loads, the state of the central nervous system, etc.

    Treatment: symptomatic.

    Interaction:

    Oxygen increases the toxicity of cisplatin, doxorubicin, disulfiram, mafenide.

    Effect on the ability to drive transp. cf. and fur:Not found.
    Form release / dosage:

    The gas is compressed.

    Packaging:

    At 6.0 m3 at a temperature of 20 ° C and a nominal filling pressure of 150 ± 5 kgf / cm2 in a steel all-toned cylinder, painted in blue, with a capacity of 40 liters, equipped with a first opening control device, with a black inscription "OXYGEN MEDICAL" on the circumference.

    Each cylinder is supplied with instructions for the medical use of the drug.
    Storage conditions:

    In a dry separate room or in open areas under a canopy that protects from atmospheric precipitation and direct sunlight, away from heating sources and open fire sources, at a temperature not exceeding 50 ° C.

    Keep out of the reach of children.

    Shelf life:

    18 months.

    Do not use after expiry date.

    Terms of leave from pharmacies:For hospitals
    Registration number:LP-002496
    Date of registration:16.06.2014
    Expiration Date:16.06.2019
    The owner of the registration certificate:SET SERVICE, LTD.SET SERVICE, LTD. Russia
    Manufacturer: & nbsp
    Information update date: & nbsp11.01.2018
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