Oxygen medical gaseous - instructions for use, dose, side effects, contraindications

Antihypoxant, significantly improves oxygen saturation of tissues and hemodynamics, protects the brain from hypoxia. Has a metabolic effect. In conditions of normobaric hypoxia, it increases the resistance of the organism to endogenous and exogenous pathological factors.

Indications:

Various diseases and conditions accompanied by hypoxia:

- respiratory diseases (including pneumonia, bronchial asthma, pulmonary edema), cardiovascular system (including chronic heart failure, cardiopulmonary insufficiency, collapse, arrhythmia);

- poisoning with carbon monoxide, hydrocyanic acid, asphyxiating substances (including chlorine, phosgene);

- weakening of breathing in the postoperative period;

- ischemia of lower extremities, trauma of limbs;

- cerebrovascular diseases of the brain.

Hyperbaric oxygenation (heart and lung operations,reconstructive surgery on the organs of the gastrointestinal tract (GIT), intoxication, anemia, peptic ulcer and duodenal ulcer, chronic hepatitis).

Hypoxicotherapy (coronary heart disease, arterial hypertension, gastrointestinal diseases, asthenia, depression, fatigue, condition after radiation therapy).

Contraindications:

Hyperbaric oxygenation (HBO) is contraindicated in the following cases: violation of patency of the auditory tubes and channels connecting the paranasal sinuses with the external environment; inflammatory processes in the nasopharynx, bronchi, lungs, ears, incl. against the background of ARVI (rhinitis, sinusitis, bronchitis, runny nose, tonsillitis, otitis, poor tolerance of flights in the airplane); presence of cysts and cavities in the lungs, bronchopleural fistula; unoccupied pneumothorax; epileptic seizures or their equivalents (after head injuries, vascular, infectious brain damage); arterial hypertension; glaucoma, hemorrhages (fresh) on the fundus and proliferative changes in the vessels of the fundus (for diabetics it is necessary to have an ophthalmologist and a permit for HBO); the bleeding is active (only after stopping it).

Carefully:

Hyperbaric oxygenation is prescribed with caution in bronchial asthma, congenital spherocytosis, high fever, optic neuritis, upper respiratory tract infection, pregnancy, simultaneous administration of cisplatin, doxorubicin, disulfiram, mafenide (increased toxicity of these drugs), pulmonary emphysema, ear barotrauma.

Pregnancy and lactation:

Special clinical studies were not conducted. Can be used in pregnancy and lactation if the potential benefit to the mother exceeds possible risk to the fetus or child.

Dosing and Administration:

Inhalation, in a concentration of 40-60%, in a mixture with air, in an amount of 4-5 l / min.

In newborns the oxygen concentration in the inhaled mixture should not exceed 40% (the risk of retrolental fibroplasia).

In elderly patients with chronic bronchitis, the inhaled oxygen concentration should be increased by 1% and not exceed 30% (most often).

Inhalation is carried out through masks or tubes, attached by means of special devices to a cylinder with oxygen, or using rubber cushions.

To introduce oxygen in high and low concentrations, different equipment is used. The minimum concentration of oxygen should not be lower than its content in atmospheric air (20.9%).

Systems for inhalation with a fixed concentration of oxygen (regardless of the patient's breathing attempts): high flow - masks that provide oxygen supply at a high flow rate; low flow - anesthesia contours. In these systems, the oxygen concentration is set by the doctor.

Systems for inhalation, providing oxygen supply in various concentrations (depending on the patient's inspiration): without recirculation - catheters and cannulas; with recirculation - oxygen masks. These systems work only in conditions of self-breathing of the patient. At the same time, the oxygen content of the gas mixture depends on the condition of the patient and the device used.

With a weakening of breathing in the postoperative period, with poisoning, intoxications use 100% oxygen or a mixture of carbonic acid.

Hyperbaric oxygenation

The procedure is carried out in special pressure chambers. For therapeutic purposes, apparatuses (single-chamber cells) are used that create an oxygen pressure of 1.2-1.6-2 atm.Conduct 1 session per day (40-60 min), treatment course 8-10 sessions. With peptic ulcer of the stomach and duodenum, chronic hepatitis is injected under a pressure of 0.7-1 excess atm. (sessions for 45 minutes); course of treatment - 15 sessions.

Hypoxicotherapy

Special training that leads to oxygen deficiency (normobaric hypoxia) by using gas mixtures with a reduced oxygen content to create artificial hypoxia (at normal atmospheric pressure).

Side effects:

Oxygen therapy: Possible myocardial ischemia in patients who underwent myocardial infarction.

Hyperbaric oxygenation: hypoglycemia, headache, numbness of fingers, transient visual impairment, ear barotrauma (ear pain, damage and rupture of the eardrum) and paranasal sinuses, fatigue, acceleration of cataract ripening; rarely - acute oxygen intoxication (convulsions, pulmonary edema).

Overdose:

With prolonged and asymptomatic use of high concentrations of oxygen (over 60-80%) with a large flow (above 6-8 l / min) there is a danger of hyperoxygenation and as a consequence - pulmonary edema.With prolonged action of oxygen, decompensatory reactions develop, manifested by functional and structural disorders in various systems and organs. Signs of oxygen intoxication appear after a certain period. Its duration may depend on individual sensitivity to oxygen, temperature and humidity of the environment, oxygen concentration in the inhaled gas mixture, emotional and physical loads, the state of the central nervous system, etc.

Treatment: symptomatic.

Interaction:

Oxygen increases the toxicity of cisplatin, doxorubicin, disulfiram, mafenide.

Special instructions:

Not represented.

Effect on the ability to drive transp. cf. and fur:

Not found.

Form release / dosage:

The gas is compressed.

Packaging:

6,2 m³ in a steel seamless canister GOST 949-73, painted in blue, with a capacity of 40 dm³, with a black inscription along the rim "OXYGEN MEDICAL".

The volume of the contents of the package is given for the conditions: an overpressure of 14.7 MPa (150 kgf / cm²), the temperature is 20 ° C. Cylinders are equipped with a valve in accordance with GOST 26460-85 and a device for controlling the first opening.

Each cylinder is supplied with instructions for the use of the drug.

Storage conditions:

In a dry separate room or outdoors under a canopy that protects from precipitation and direct sunlight, away from heating sources and open fire sources, at temperatures from minus 50 FROM up to 50 ° С.

Keep out of the reach of children.

Shelf life:

18 months.

Do not use after expiry date.

Terms of leave from pharmacies:For hospitals

Registration number:LP-002983

Date of registration:29.04.2015

Expiration Date:29.04.2020

The owner of the registration certificate:OXI, CJSCOXI, CJSC Russia

Manufacturer: & nbsp

OXI CJSC Russia

Information update date: & nbsp11.01.2018

Illustrated instructions

Instructions

Oxygen medical gaseous (Medical gaseous oxygen)