Oxygen gaseous medical - instructions for use, dose, side effects, contraindications

Antihypoxic, significantly improves oxygen saturation of tissues and hemodynamics, protects the brain from hypoxia. Has a metabolic effect. In conditions of normobaric hypoxia, it increases the resistance of the organism to endogenous and exogenous pathological factors.

Indications:

Various diseases accompanied by hypoxia:

- Diseases of the respiratory system (including pneumonia, bronchial asthma), cardiovascular system (including chronic heart failure, collapse, arrhythmias, pulmonary edema);

- poisoning with carbon monoxide, hydrocyanic acid, asphyxiating substances (including chlorine, phosgene);

- weakening of breathing in the postoperative period;

- ischemia of the lower extremities, trauma of the limbs;

- cerebrovascular diseases;

- hyperbaric oxygenation (heart and lung operations,reconstructive surgery on the gastrointestinal tract organs (GI) tract, intoxication, anemia, peptic ulcer and 12 duodenal ulcer, chronic hepatitis);

- hypoxic therapy (coronary heart disease, arterial hypertension, gastrointestinal diseases, asthenia, depression, fatigue, condition after radiation therapy).

Contraindications:Hyperbaric oxygenation: The presence of cavities in the lung, bronchopleural fistula, undocked pneumothorax; violation of patency of the auditory tubes and ducts connecting the sinuses with the external environment; acute respiratory viral infections; epilepsy; arterial hypertension; neoplasms.

Carefully:With hyperbaric oxygenation: Bronchial asthma, congenital spherocytosis, high fever, optic neuritis, upper respiratory tract infections, pregnancy, simultaneous cisplatin, doxorubicin, disulfiram, mafenida (increasing medicaments toxicity data), emphysema, barotrauma ears.

Pregnancy and lactation:

Due to the lack of special clinical studies during pregnancy and breastfeeding, the drug should be used,when the benefit to the mother exceeds the potential risk to the fetus and / or the child and under the direct supervision of the physician.

Dosing and Administration:

Inhalation, in a concentration of 40-60%, in a mixture with air, in an amount of 4-5 l / min.

When breathing is weakened in the postoperative period, when poisoning, intoxication is used 100% oxygen or a mixture of carbonic acid.

Dosage regimen in all age groups, except for newborns, coincides.

To introduce oxygen in high and low concentrations, different equipment is used. The minimum concentration of oxygen should not be lower than its content in atmospheric air (20.9%).

Systems for inhalation with a fixed concentration of oxygen (regardless of the patient's breathing attempts): high flow - masks that provide oxygen supply at a high flow rate; low flow - anesthesia contours. In these systems, the oxygen concentration is set by the doctor.

Systems for inhalation, providing the supply of different concentrations of oxygen (depending on the patient's inspiration): without recycling - catheters and cannulas; with recirculation - oxygen masks.These systems work only in conditions of self-breathing of the patient who inhales the gas mixture. The oxygen content of the gas mixture will depend on the condition of the patient and the device used.

In newborns, the concentration of oxygen in the inhaled mixture should not exceed 40% (the risk of retrolental fibroplasia).

In elderly patients with chronic bronchitis, the inhaled oxygen concentration should be increased by 1% and not exceed 30% (most often).

Hyperbaric oxygenation: The procedure is carried out in special pressure chambers, for therapeutic purposes apparatuses (single-chamber chambers) are used that create an oxygen pressure of 1.2-1.6-2 atm. Conduct 1 session per day (40-60 minutes), the course of treatment - 8-10 sessions.

With gastric ulcer and duodenal ulcer, chronic hepatitis is injected under a pressure of 0.7-1 excess atm. (sessions for 45 minutes); course of treatment - 15 sessions.

Hypoxicotherapy: special training, leading to oxygen deficiency (normobaric hypoxia) by using gas mixtures with a reduced oxygen content to create artificial hypoxia (at normal atmospheric pressure).

Side effects:

Hyperbaric oxygenation: hypoglycemia, headache, numbness of fingers, transient visual impairment, barotrauma of the ears (ear pain, damage and rupture of the eardrum) and paranasal sinuses, fatigue, acceleration of cataract ripening; rarely - acute oxygen intoxication (convulsions, pulmonary edema).

Oxygen therapy: myocardial ischemia in patients who underwent myocardial infarction.

Overdose:

With prolonged and unsystematic application of high concentrations of oxygen (over 60-80%) with a large flux (over 6-8 l / min) there is a danger of hyperoxygenation and as a consequence - pulmonary edema. With prolonged action of oxygen, decompensatory reactions develop, manifested by functional and structural disorders in various systems and organs. Signs of oxygen intoxication appear after a certain period. Its duration may depend on individual sensitivity to oxygen, temperature and humidity of the environment, concentration in the inspired gas mixture, emotional and physical loads, the state of the central nervous system, etc.

Treatment: symptomatic.

Interaction:Not studied.

Form release / dosage:

The gas is compressed.

Packaging:

6,24 m³ in a cylinder with a capacity of 40 dm³.

The volume of the contents of the package is given for conditions: an overpressure of 14.7 MPa (150 kgf / cm²), the temperature is 20 ° C.

Cylinders are made of steel seamless blue color with a black inscription "Oxygen medical" on the circumference.

Cylinders are equipped with a valve and a first-opening control device complete with instructions for medical use.

Storage conditions:

In a dry separate room or outdoors under a canopy, protected from atmospheric precipitation and direct sunlight, away from heating sources and open fire sources at a temperature not exceeding 50 ° C.

Keep out of the reach of children.

Shelf life:

18 months.

Do not use after the expiry date indicated on the bottle.

Terms of leave from pharmacies:For hospitals

Registration number:LP-002609

Date of registration:03.09.2014

Expiration Date:03.09.2019

The owner of the registration certificate:OZONE, LLC OZONE, LLC Russia

Manufacturer: & nbsp

OZONE, LLC Russia

Information update date: & nbsp11.01.2018

Illustrated instructions

Instructions

Oxygen gaseous medical (Medical gaseous oxygen)