Oxygen gaseous medical - instructions for use, dose, side effects, contraindications

Antihypoxic, significantly improves oxygen saturation of tissues and hemodynamics, protects the brain from hypoxia. Has a metabolic effect. In conditions of normobaric hypoxia, it increases the resistance of the organism to endogenous and exogenous pathological factors.

Indications:

- Various diseases are accompanied by hypoxia: respiratory diseases (including pneumonia, bronchial asthma), cardiovascular system (including chronic heart failure, collapse, arrhythmias, pulmonary edema);

- poisoning with carbon monoxide (carbon monoxide), hydrocyanic acid, asphyxiating substances (including chlorine, phosgene);

- weakening of breathing in the postoperative period;

- ischemia of lower extremities, trauma of limbs;

- cerebrovascular diseases of the brain;

- hyperbaric oxygenation in heart and lung operations, reconstructive surgery on the organs of the gastrointestinal tract (GIT), intoxication, anemia, peptic ulcer and duodenal ulcer, chronic hepatitis;

- hypoxic therapy for ischemic heart disease, arterial hypertension, gastrointestinal diseases, asthenia, depression, increased fatigue, after radiation therapy.

Contraindications:

Hyperbaric oxygenation: presence of cavities in the lungs, unoccupied pneumothorax, bronchopleural fistula; violation of patency of the auditory tubes and ducts connecting the sinuses with the external environment; acute respiratory viral infections; epilepsy; arterial hypertension; neoplasms.

Carefully:

Hyperbaric oxygenation: bronchial asthma, congenital spherocytosis, high fever, optic neuritis, upper respiratory tract infections, pregnancy, simultaneous administration of cisplatin, doxorubicin, disulfiram, mafenide (increasing the toxicity of these drugs); emphysema of the lungs; barotrauma of the ears.

Pregnancy and lactation:

Due to the lack of special clinical studies during pregnancy and breastfeeding, the drug should be used when the benefit to the mother exceeds the potential risk to the fetus or child and under the direct supervision of the doctor.

Dosing and Administration:

Inhalation, in a concentration of 40-60%, in a mixture with air, in an amount of 4-5 l / min. When breathing is weakened in the postoperative period, when poisoning, intoxication is used 100% oxygen or a mixture thereof with carbon dioxide (carbon dioxide).

Dosage regimen in all age groups, except for newborns, coincides.

To introduce oxygen in high and low concentrations, different equipment is used. The minimum concentration of oxygen should not be lower than its content in atmospheric air (20.9%).

Systems for inhalation with a fixed concentration of oxygen (regardless of the patient's breathing attempts): high flow - masks that provide oxygen supply at a high flow rate; low flow - anesthesia contours. In these systems, the oxygen concentration is set by the doctor.

Systems for inhalation,Providing a different oxygen concentration (depending on the inspiration of the patient): without recirculation - catheters and cannulas; with recirculation - oxygen masks. These systems work only in conditions of self-breathing of the patient who inhales the gas mixture. The oxygen content of the gas mixture will depend on the condition of the patient and the device used.

In newborns the oxygen concentration in the inhaled mixture should not exceed 40% (the risk of retrolental fibroplasia).

In elderly patients with chronic bronchitis the inhaled oxygen concentration should be increased by 1% and not exceed 30% (most often).

Hyperbaric oxygenation: the procedure is carried out in special pressure chambers, for therapeutic purposes apparatuses (single-chamber chambers) are used that create an oxygen pressure of 1.2-1.6-2.0 atm. Conduct 1 session per day (40-60 min); course of treatment 8-10 sessions.

With peptic ulcer of stomach and duodenum, chronic hepatitis is introduced under a pressure of 0.7-1 excess atmospheric pressure. (sessions for 45 minutes); course of treatment - 15 sessions. Hypoxic therapy: conduct special training, leading to oxygen deficiency (normobaric hypoxia),by using gas mixtures with a reduced oxygen content to create artificial hypoxia (at normal atmospheric pressure).

Side effects:

Hyperbaric oxygenation: hypoglycemia, headache, numbness of fingers, transient blurred vision, ear barotrauma (ear pain, and damage to the eardrum) and paranasal sinuses, fatigue, accelerating the maturation of cataracts, rarely - acute oxygen toxicity (convulsions, pulmonary edema).

Oxygen therapy: myocardial ischemia in patients with myocardial infarction.

Overdose:

With prolonged and unsystematic application of high concentrations of oxygen (over 60-80%) with a large flux (above 6-8 l / min) there is a danger of hyperoxygenation and, as a consequence, pulmonary edema. With prolonged action of oxygen, decompensatory reactions, manifested by functional and structural disorders in various systems and organs.

Signs of oxygen intoxication appear after a certain period. Its duration may depend on individual sensitivity to oxygen, temperature and humidity of the environment, concentration in the inhaled gas mixture,emotional and physical loads, the state of the central nervous system.

Treatment: symptomatic.

Interaction:

Not studied.

Special instructions:

In newborns, due to the increased risk of retinopathy, an increase in the oxygen pressure above 0.079 atm is not recommended.

Effect on the ability to drive transp. cf. and fur:

In therapeutic doses, oxygen gaseous medical does not affect the ability to perform potentially dangerous activities requiring increased concentration of attention and speed of psychomotor reactions.

Form release / dosage:The gas is compressed.

Packaging:

By 156 dm³ in a cylinder of 1 liter, 780 dm³ in a 5-liter balloon, 1560 dm³ in a cylinder with a volume of 10 liters, 3120 dm³ in a cylinder of 20 liters or 6240 dm³ in a cylinder of 40 liters.

The volume of the contents of the package is given at an excess pressure of 14.7 ± 0.5 MPa (150 ± 5 kgf / cm²) and a temperature of 20 ° C.

Cylinders are produced in accordance with GOST 949-73, equipped with a valve in accordance with GOST 26460-85 and a device for monitoring the first opening. Each cylinder is supplied with instructions for use.

Cylinders are made of steel seamless blue color with a black inscription "Oxygen medical" on the circumference.

Storage conditions:

In a dry separate room or outdoors under a canopy that protects from atmospheric precipitation and direct sunlight, away from heating sources and open fire sources, at an air temperature of minus 50 ° C to 50 ° C.

Keep out of the reach of children.

Shelf life:

18 months from the date of filling the cylinder.

Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:LP-003738

Date of registration:19.07.2016

Expiration Date:19.07.2021

The owner of the registration certificate:Mariinsk-gaz, Open CompanyMariinsk-gaz, Open Company Russia

Manufacturer: & nbsp

Mariinsk-gaz, Open Company Russia

Information update date: & nbsp11.01.2018

Illustrated instructions

Instructions

Oxygen gaseous medical (Medical gaseous oxygen)