Oxygen medical gaseous - instructions for use, dose, side effects, contraindications

Antihypoxant, significantly improves oxygen saturation of tissues, improves hemodynamics and protects the brain from hypoxia. Has a metabolic effect. In conditions of normobaric hypoxia, it increases the resistance of the organism to endogenous and exogenous pathological factors.

Indications:

Various diseases and conditions accompanied by hypoxia:

respiratory diseases (including pneumonia, bronchial asthma, pulmonary edema), cardiovascular system (including chronic heart failure, cardiopulmonary insufficiency, collapse, arrhythmia);
aboutetching with carbon monoxide, hydrocyanic acid, asphyxiating substances (including chlorine, phosgene);
aboutweakening of respiration in the postoperative period;
andlower extremity hermium, limb trauma;
cerebrovascular diseases of the brain.

Hyperbaric oxygenation (heart and lung operations, reconstructive operations on the organs of the gastrointestinal tract (GIT), intoxication, anemia, peptic ulcer of the stomach and duodenum, chronic hepatitis).

Hypoxicotherapy (coronary heart disease, arterial hypertension, gastrointestinal diseases, asthenia, depression, fatigue, condition after radiation therapy).

Contraindications:

Hyperbaric oxygenation (HBO) is contraindicated in the following cases: violation patency of the auditory tubes and ducts connecting the paranasal sinuses with the external environment; inflammatory processes in the nasopharynx, bronchi, lungs, ears, incl. against the background of ARVI (rhinitis, sinusitis, bronchitis, runny nose, tonsillitis, otitis, poor tolerance of flights in the airplane); presence of cysts and cavities in the lungs, bronchopleural fistula; unoccupied pneumothorax; neoplasms; epileptic seizures or their equivalents (after head injuries, vascular, infectious brain damage); arterial hypertension; glaucoma, hemorrhages (fresh) on the fundus and proliferative changes in the vessels of the fundus (for patients with diabetes, an ophthalmologist is required and a permitfor HBO); the bleeding is active (only after stopping it).

Carefully:

Hyperbaric oxygenation is prescribed with caution in bronchial asthma, congenital spherocytosis, high fever, optic neuritis, upper respiratory tract infection, pregnancy, simultaneous administration of cisplatin, doxorubicin, disulfiram, mafenide (oxygenation helps to increase the toxicity of these medicines), pulmonary emphysema, ear barotrauma.

Pregnancy and lactation:

It can be used in pregnancy and lactation if the potential benefit to the mother exceeds the possible risk to the fetus or the baby.

Dosing and Administration:

Inhalation, in a concentration of 40-60%, in a mixture with air, in an amount of 4-5 l / min.

When breathing is weakened in the postoperative period, when poisoning, intoxication is used 100% oxygen or a mixture of carbonic acid.

Dosage regimen in all age groups, except for newborns, coincides.

To introduce oxygen in high and low concentrations, different equipment is used. The minimum concentration of oxygen should not be lower than its content in atmospheric air (20.9%).

Systems for inhalation with a fixed concentration of oxygen (regardless of the patient's breathing attempts): high flow - masks that provide oxygen supply at a high flow rate; low flow - anesthesia contours. In these systems, the oxygen concentration is set by the doctor.

Systems for inhalation, providing the supply of different concentrations of oxygen (depending on the patient's inspiration): without recycling - catheters and cannulas; with recirculation - oxygen masks. These systems work only in conditions of self-breathing of the patient who inhales the gas mixture. The oxygen content of the gas mixture will depend on the condition of the patient and the device used.

In newborns the oxygen concentration in the inhaled mixture should not exceed 40% (the risk of retrolental fibroplasia).

In elderly patients with chronic bronchitis the inhaled oxygen concentration should be increased by 1% and not exceed 30% (most often).

Hyperbaric oxygenation: The procedure is carried out in special pressure chambers, for therapeutic purposes use apparatus (single-chamber), creating an oxygen pressure of 1.2-1.6-2 atm.Conduct 1 session per day (40-60 minutes), the course of treatment - 8-10 sessions.

With peptic ulcer of stomach and duodenum, chronic hepatitis is introduced under a pressure of 0.7-1 excess atmospheric pressure. (sessions for 45 minutes); course of treatment - 15 sessions.

Hypoxic therapy: special training, leading to oxygen insufficiency (normobaric hypoxia) by using gas mixtures with a reduced oxygen content to create artificial hypoxia (at normal atmospheric pressure).

Side effects:

Hyperbaric oxygenation: Hypoglycemia, headache, numbness of fingers, transient visual impairment, ear barotrauma (ear pain, damage and rupture of the eardrum) and paranasal sinuses, fatigue, acceleration of cataract ripening, rarely acute oxygen intoxication (convulsions, pulmonary edema).

Oxygen therapy: Possible ischemia of the myocardium in patients who underwent myocardial infarction.

Overdose:

With prolonged and uncontrolled (asymptomatic) application of high concentrations of oxygen (over 60-80%) with a large flux (above 6-8 l / min) there is a danger of hyperoxygenation and as a consequence - the development of pulmonary edema.With prolonged action of oxygen, decompensatory reactions develop, manifested by functional and structural disorders in various systems and organs. Signs of oxygen intoxication appear after a certain period. Its duration may depend on individual sensitivity to oxygen, temperature and humidity of the environment, concentration in the inspired gas mixture, emotional and physical loads, the state of the central nervous system, etc.

Treatment: Symptomatic.

Interaction:

Oxygen increases the toxicity of cisplatin, doxorubicin, disulfiram, mafenide.

Effect on the ability to drive transp. cf. and fur:

The effect of the drug on the ability to drive vehicles and mechanisms is not revealed.

Form release / dosage:The gas is compressed.

Packaging:

At 6.0 m³ in a cylinder with a capacity of 40 dm³.

The volume of the contents of the package is given for conditions: an overpressure of 14.7 MPa (150 kgf / cm²), the temperature is 20 ° C.

The steel seamless cylinders, painted in blue, are used, with the inscription "KISLOROD MEDICAL" in black on the circumference. Cylinders are equipped with a valve and a first-opening control device.

Each cylinder is supplied with instructions for the use of the drug.

Storage conditions:

In a dry separate room or outdoors under a canopy that protects from atmospheric precipitation and direct sunlight, away from heating sources and open fire sources, at temperatures from minus 50 ° C to 50 ° C.

Keep out of the reach of children.

Shelf life:

18 months.

Do not use after expiry date.

Terms of leave from pharmacies:For hospitals

Registration number:LP-003805

Date of registration:22.08.2016

Expiration Date:22.08.2021

The owner of the registration certificate:Vita, Open CompanyVita, Open Company Russia

Manufacturer: & nbsp

Vita, Open Company Russia

Information update date: & nbsp11.01.2018

Illustrated instructions

Instructions

Oxygen medical gaseous (Medical gaseous oxygen)