Oxygen medical gaseous - instructions for use, dose, side effects, contraindications

Antihypoxic agent, increases oxygenation of tissues, improves hemodynamics and protects the brain from hypoxia. Has a metabolic effect. In conditions of normobaric hypoxia, it increases the resistance of the organism to endogenous and exogenous pathological factors.

Indications:

Various diseases accompanied by hypoxia:

- diseases of the respiratory system (including pneumonia, bronchial asthma);

- diseases of the cardiovascular system (including chronic heart failure, arrhythmias, pulmonary edema, collapse);

- poisoning with carbon monoxide, hydrocyanic acid, asphyxiating substances (including chlorine, phosgene);

- weakening of breathing in the postoperative period;

- ischemia of the lower extremities;

- traumas of limbs;

- cerebrovascular diseases of the brain;

- hyperbaric oxygenation (heart and lung operations, reconstructive surgery on the organs of the gastrointestinal tract, intoxication, anemia, peptic ulcer and duodenal ulcer, chronic hepatitis);

- Hypoxia (ischemic heart disease, arterial hypertension, gastrointestinal disorders, asthenia, depression, fatigue, condition after radiation therapy).

Contraindications:

Hyperbaric oxygenation: the presence of cavities in the lungs, bronchopleural fistula, unoccupied pneumothorax; violation of patency of the auditory tubes and ducts connecting the sinuses with the external environment; acute respiratory viral infection; epilepsy; neoplasms; arterial hypertension.

Carefully:

Hyperbaric oxygenation: bronchial asthma, congenital spherocytosis, high fever, optic neuritis, upper respiratory tract infections, pregnancy, simultaneous administration of cisplatin, doxorubicin, disulfiram, mafenide (increasing the toxicity of these drugs), emphysema, malignant neoplasms, barotrauma of the ears.

Pregnancy and lactation:

Can be used during pregnancy and during breastfeeding, if the potential benefit to the mother exceeds the possible risk to the fetus or child.

Dosing and Administration:

To introduce oxygen in high and low concentrations, different equipment is used. The minimum concentration of oxygen should not be lower than its content in atmospheric air (20.9%).

Systems for inhalation with a fixed concentration of oxygen (regardless of the patient's breathing attempts): high flow - masks that provide oxygen supply at a high flow rate; low flow - anesthesia contours. In these systems, the oxygen concentration is set by the doctor.

Systems for inhalation, providing the supply of different concentrations of oxygen (depending on the patient's inspiration): without recycling - catheters and cannulas; with recirculation - oxygen masks.These systems work only in conditions of self-breathing of the patient who inhales the gas mixture. The oxygen content of the gas mixture will depend on the condition of the patient and the device used. In newborns, the concentration of oxygen in the inhaled mixture should not exceed 40% (the risk of retrolental fibroplasia). In elderly patients with chronic bronchitis, the inhaled oxygen concentration should be increased by 1% and not exceed 30% (most often).

Inhalation: in a concentration of 40-60%, in a mixture with air, in an amount of 4-5 l / min. When breathing is weakened in the postoperative period, when poisoning, intoxication is used 100% oxygen or a mixture of carbonic acid. Inhalation is performed through masks, cannulas, catheters or using rubber cushions.

Hyperbaric oxygenation: the procedure is carried out in special pressure chambers, for therapeutic purposes apparatuses producing an oxygen pressure of 1.2-2 atm are used. Conduct 1 session per day (40-60 minutes), the course of treatment - 8-10 sessions.

With peptic ulcer of stomach and duodenum, chronic hepatitis is administered under control of 0.7-1 excess atm. (sessions for 45 minutes); course of treatment - 15 sessions.

Hypoxic therapy: special training for oxygen deficiency (normobaric hypoxia) by using gas mixtures with a reduced oxygen content to create artificial hypoxia (at normal atmospheric pressure).

Side effects:

Hyperbaric oxygenationhypoglycaemia, headache, numbness of fingers, transient visual impairment, barotrauma of the ears (ear pain, damage and rupture of the tympanic membrane) and paranasal sinuses, fatigue, acceleration of cataract ripening, rarely acute oxygen intoxication (convulsions, pulmonary edema).

Oxygen therapy: myocardial ischemia in patients with myocardial infarction.

Overdose:

With prolonged and unsystematic application of high concentrations of oxygen (over 60-80%) with a large flux (over 6-8 l / minute) there is a danger of hyperoxygenation and as a consequence - pulmonary edema. With prolonged action of oxygen, decompensatory reactions develop, manifested by functional and structural disorders in various systems and organs.

Signs of oxygen intoxication appear after a certain period.Its duration may depend on individual sensitivity to oxygen, temperature and humidity of the environment, concentration in the inhaled gas mixture, emotional and physical loads, the state of the central nervous system, and so on.

Treatment: symptomatic.

Interaction:

Not investigated.

Effect on the ability to drive transp. cf. and fur:Not found.

Form release / dosage:

The gas is compressed.

Packaging:

Compressed gas 0,156 m³ in steel cylinders with a capacity of 1 dm³.

Compressed gas 0.312 m³ in steel cylinders with a capacity of 2 dm³.

Compressed gas 0,78 m³ in steel cylinders with a capacity of 5 dm³.

Compressed gas 1,56 m³ in steel cylinders with a capacity of 10 dm³.

Compressed gas 6,3 m³ in steel cylinders with a capacity of 40 dm³.

Compressed gas 7.8 m³ in steel cylinders with a capacity of 50 dm³.

Compressed gas 31,5 m³ in monoblocks (a bundle of steel cylinders 5 pieces of 40 dm³) with a capacity of 200 dm³.

Compressed gas 10.3 m³ (at an excess pressure of 19.6 MPa) in steel cylinders with a capacity of 50 dm³.

Cylinders are steel, equipped with an oxygen cylinder valve and a device for controlling the first opening.

Each cylinder is marked with a label, accompanied by a certificate of quality and instructions for use.

Storage conditions:

Store in a dry separate room, away from heat sources and open flame sources at a temperature not exceeding 50 ° C.

Shelf life:

18 months from the filling of cylinders.

Do not use after the expiration date.

Terms of leave from pharmacies:For hospitals

Registration number:LP-000654

Date of registration:28.09.2011

The owner of the registration certificate:CRYOGEN FIRM, LTD. CRYOGEN FIRM, LTD. Russia

Manufacturer: & nbsp

CRYOGEN FIRM, LTD. Russia

Information update date: & nbsp09.07.2014

Illustrated instructions

Instructions

Oxygen medical gaseous (Medical gaseous oxygen)