Strengthens the antidepressant effect of monoamine oxidase inhibitors, photosensitizing effects of thiazide diuretics, tetracyclines, sulfonamides, piroxicam, quinolones.
Simultaneous use with paroxetine, fluoxetine, sertraline, fluvoxamine or citalopram aggravates hemolytic reactions and the course of "serotonin syndrome" (dizziness, headache, nausea, vomiting, epigastric pain, anxiety, anxiety, confusion, confusion, anxiety and irritability).
Lengthens sleep, induced by taking medications for general anesthesia and narcotic analgesics, shortens sleep time caused by barbiturates.
Reduces the hypotensive effect of reserpine, as well as the concentration in the blood plasma of cyclosporine, indinavir, theophylline.
Reduces toxicity of digoxin.
Increases the risk of bleeding with simultaneous use with ethinyl estradiol and desogestrel.