The drug is used intramuscularly and intravenously.
The course of treatment is usually 4-14 days; with complicated infections, a longer duration of administration may be required. The course of treatment for infections caused by Streptococcus pyogenes should be at least 10 days;
For adults and for children over 12 years old
The average daily dose is 1-2 g of ceftriaxone once a day or 0, 5-1 g every 12 hours. In severe cases or in cases of infections caused by moderately sensitive pathogens, the daily dose may be increased to 4 g. The course of treatment is usually 4-14 days; with complicated infections, a longer duration of administration may be required.
The course of treatment for infections caused by Streptococcus pyogenes , should be not less than 10 days.
For newborns
For a single daily dosage, the following scheme is recommended:
For newborns (up to 2 weeks of age): 20-50 mg / kg of body weight per day (a dose of 50 mg / kg body weight is not recommended because of immature enzyme system of newborns).
For infants and children under 12 years of age
The daily dose is 20-75 mg / kg body weight.
Children with a body weight of 50 kg and above should adhere to the dosage for adults. A dose of more than 50 mg / kg of body weight should be given as an intravenous infusion, for at least 30 minutes.
For treatment skin and soft tissue infections the recommended daily intake in children is 50-75 mg / kg, divided into 2 divided doses (every 12 hours). The total daily intake for children should not exceed 2 g.
In the treatment acute otitis media in children, a single intramuscular injection of the drug at a dose of 50 mg / kg is recommended (but not more than 1.0 g per day)
Duration of therapy - depends on the course of the disease.
Meningitis
In bacterial meningitis in newborns and in children, the initial dose is 100 mg / kg of body weight once a day (maximum 4 g). Further - 100 mg / kg of body weight per day (no more than 4.0 g) once a day, divided into 2 doses (every 12 hours).The best results were achieved with the following periods of therapy:
| Causative agent | Duration of therapy |
| Neisseria meningitidis | 4 days |
| Haemophilus influenzae | 6 days |
| Streptococcus pneumoniae | 7 days |
| Sensitive Enterobacteriacease | 10-14 days |
Uncomplicated gonorrhea
For the treatment of uncomplicated gonorrhea caused by both generative and non-penicillinase-resistant strains, the recommended dose is 250 mg once intramuscularly.
Prevention in the pre- and postoperative period
Before infected or suspected infected surgical interventions to prevent postoperative infections, depending on the danger of infection, for 30-90 min. before surgery, a single administration of ceftriaxone in a dose of 1.0 g is recommended. For operations on the colon and rectum, additional administration of a drug from the 5-nitroimidazole group is recommended.
Lack of kidney and liver function
In patients with impaired renal function, under the condition of normal liver function, a dose of ceftriaxone is not necessary to reduce. Only with kidney failure (creatinine clearance below 10 ml / min), it is necessary that the daily dose of ceftriaxone does not exceed 2 g.
In patients with impaired liver function, if the function of the kidneys is maintained, the dose of ceftriaxone should not be reduced.
In cases of simultaneous presence of severe pathology of the liver and kidneys, the concentration of ceftriaxone in the blood plasma should be regularly monitored. (The daily dose should not exceed 2.0 g.). Patients on hemodialysis do not require an additional dose after a hemodialysis session, however, it is necessary to monitor the concentration of ceftriaxone in the blood plasma, since the excretion of the drug in such patients may be slowed down (dose adjustment may be required).
Intramuscular injection
For intramuscular injection of 0.25 g and 0.5 g of the drug, it is necessary to dissolve it in 2.0 ml of a 1% solution of lidocaine, and for 1 g of the drug - in 3.5 ml of a 1% solution of lidocaine and insert deep into the gluteus muscle (it is recommended to administer not more than 1 g of the drug in one buttock). A solution of lidocaine can never be administered intravenously!
Intravenous administration
For intravenous injection, 0.25 g or 0.5 g of the drug should be dissolved in 5 ml, and for 1 g - in 10 ml of sterile distilled water and administered intravenously slowly over 2-4 min.
Intravenous infusion
Duration of intravenous infusion is at least 30 min. For intravenous infusion, 2 g of powder should be diluted in 40 ml of a solution that does not contain calcium ions (for example: 0.9% solution of sodium chloride, 5% dextrose solution, 10% dextrose solution, 5% fructose solution)
Rules for the preparation and administration of solutions: Use only freshly prepared solutions.