Applied intravenously (struyno, drip) or intramuscularly.
Adults and children over 12 years of age
1-2 g per day with an interval of 24 h or 0.5-1 g every 12 h. In severe cases or in infections whose causative agents have only mild sensitivity to ceftriaxone, the daily dose can be increased to 4 g.
Older patients are given usual doses for adults without adjustments for age.
Children
Newborns (up to 2 weeks): 20-50 mg / kg once a day (interval 24 hours). The daily dose should not exceed 50 mg / kg of body weight. When determining the dose, no distinction is made between full and premature children.
Children from the 3rd week to 12 years: 20-75 mg / kg once a day (interval 24 hours). The daily dose should not exceed 2 grams!
Children with a body weight above 50 kg are prescribed doses for adults.
Intravenous doses at a rate of 50 mg / kg or higher should be administered drip for at least 30 minutes.
Duration of treatment
Depends on the type and sensitivity of the pathogen and the severity of the disease; usually is 7-14 days; with a complicated infection, longer treatment may be required; infection caused by Streptococcus pyogenes, - not less than 10 days.
The administration of ceftriaxone should be continued within 48-72 hours after the temperature normalization and bacteriological confirmation of the eradication of the pathogen.
Dosing in special cases
Bacterial meningitis in children from 3 weeks to 12 years: a dose of 100 mg / kg administered once a day (an interval of 24 hours). The daily dose should not exceed 4 grams! The duration of treatment for meningococcal meningitis is at least 4 days; with meningitis caused by Haemophilus influenzae, - 6 days, Streptococcus pneumoniae, - 7 days.
Lyme disease \ 50 mg / kg (the highest daily dose is 2 g) for adults and children once a day for 14 days.
Uncomplicated gonorrhea: 250 mg once intramuscularly.
Prevention of postoperative infection: depending on the degree of infectious risk - 1-2 g intravenously once for 30-90 minutes before the operation. In operation on the large intestine ceftriaxone It is used in combination with drugs that affect the anaerobic flora.
Sick from impaired renal function: in the case of preterminal renal failure (with creatinine clearance less than 10 ml / min), it is necessary that the daily dose does not exceed 2 g. In the remaining cases, no normal dose adjustment is required if normal liver function is performed.
Sick from hepatic dysfunction: under the condition of normal kidney function, dose adjustment is not required.
Severe renal and hepatic insufficiency: should regularly monitor the concentration of ceftriaxone in the blood plasma and, if necessary, adjust the dose.
Patients on dialysis: additional administration of the drug after dialysis is not required. It is necessary to monitor the concentration of ceftriaxone in the serum for dose adjustment, since the rate of excretion of the drug in these patients may be reduced.
For intramuscular injection the contents of the vial are dissolved as follows:
Contents of the bottle Solvent (water for injection)
250 mg 0.9 ml
500 mg 1.8 ml
1 g 3.6 ml
After preparation, each ml of the solution contains about 250 mg of the drug in terms of ceftriaxone.
Ceftriaxone is injected into a relatively large muscle (eg, buttock); Trial aspiration helps to avoid unintentional insertion into the blood vessel. It is recommended to inject no more than 1000 mg of the drug into one muscle.
To reduce pain with intramuscular injection, instead of water for injection, use, if there are no contraindications, 1% lidocaine solution. Do not administer ceftriaxone solution in 1% lidocaine solution intravenously.
For intravenous administration the contents of the vial are dissolved as follows:
Contents of the bottle Solvent (water for injection)
250 mg 2.4 ml
500 mg 4.8 ml
1 g 9.6 ml
After preparation, each ml of the solution contains about 100 mg of the drug in terms of ceftriaxone. The solution is administered slowly for 2-4 minutes.
For intravenous infusion dissolve 2 g of ceftriaxone in 40 ml of a calcium-free infusion solution (for example, 0.9% sodium chloride solution, 2.5%, 5% or 10% glucose solution (dextrose), 5% levulose solution, 0.45% sodium chloride solution and 2.5% glucose solution, 6% dextran 70 solution in 5% glucose solution). The solution is introduced for 30 minutes.