The drug is used intramuscularly or intravenously.
For adults and for children over 12 years old The average daily dose is 1-2 g of ceftriaxone once a day or 0.5-1 g every 12 hours.
In severe cases or in cases of infections caused by moderately sensitive pathogens, the daily dose may be increased to 4 g.
For newborns For a single daily dosage, the following regimen is recommended: For newborns (up to 2 weeks of age): 20-50 mg / kg of body weight once a day (a dose of 50 mg / kg of body weight is not recommended because of the immature enzyme system of newborns).
For infants and children under 12 years of age
The daily dose is 20-75 mg / kg of body weight once a day. Children with a body weight of 50 kg and above should adhere to the dosage for adults. A dose of more than 50 mg / kg body weight should be given as an IV infusion for at least 30 minutes.
Duration of therapy
Depends on the course of the disease. As always with antibiotic therapy, ceftriaxone should be continued for at least 48-72 hours after the temperature is normalized and the eradication of the pathogen is confirmed.
Meningitis
In bacterial meningitis in newborns and in children, the initial dose is 100 mg / kg of body weight once a day (maximum 4 g). As soon as it was possible to isolate the pathogenic microorganism and determine its sensitivity, the dose should be reduced accordingly.The best results were achieved with the following periods of therapy:
| Causative agent | Duration of therapy |
| Neisseria meningitides | 4 days |
| Haemophilus influenzae | 6 days |
| Streptococcus pneumoniae | 7 days |
| Sensitive | 10-14 days |
| Enterobacteriaceae |
|
Gonorrhea
For the treatment of gonorrhea caused by both generative and non-penicillinase-resistant strains, the recommended dose is 250 mg once intramuscularly.
Borrelia Lyme:
50 mg / kg (the highest daily dose -2g) for adults and children over 12 years, once a day for 14 days.
Prevention in the pre- and postoperative period
Before infected or presumptively infected surgical interventions to prevent postoperative infections, depending on the risk of infection, one-time administration of ceftriaxone in a dose of 1 -2 g is recommended 30-90 minutes prior to surgery.
Lack of kidney and liver function
In patients with impaired renal function, under the condition of normal liver function, a dose of ceftriaxone is not necessary to reduce. Only if the kidneys are deficient in the preterminal stage (creatinine clearance below 10 ml / min) it is necessary that the daily dose of ceftriaxone does not exceed 2 g.
In patients with impaired liver function, if the function of the kidneys is maintained, the dose of ceftriaxone should not be reduced.
In cases of simultaneous presence of severe pathology of the liver and kidneys, the concentration of ceftriaxone in serum should be monitored regularly. In patients undergoing hemodialysis, the dose of the drug after this procedure is not necessary to change.
Intramuscular injection
For the / m introduction, 1g of the drug should be diluted in 3.5ml of a 1% solution of lidocaine and injected deep into the relatively large muscle (gluteal), it is recommended to inject no more than 1g of the drug into one buttock. A solution of lidocaine can never be administered intravenously!
Trial aspiration helps to avoid unintentional entry of the drug into the vessel.
Intravenous administration
For intravenous injection of 1g of the drug should be diluted in 10 ml of sterile distilled water and injected iv slowly for 2-4 minutes.
Intravenous infusion
The duration of IV is at least 30 minutes. For intravenous infusion, 2 g of the powder should be diluted in approximately 40 ml of a calcium free solution, for example: in a 0.9% solution of sodium chloride, in a 5% dextrose solution, in a 10% solution of dextrose, 5% solution of fructose.